AOCNP BOARD EXAM
COMPREHENSIVE PRACTICE
QUESTIONS & VERIFIED ANSWERS (A+
GUARANTEE)
1. Which of the following molecular markers is a predictive biomarker for response to PARP
inhibitors in patients with ovarian or breast cancer?
A. HER2 amplification
B. EGFR T790M
C. KRAS mutation
D. BRCA1/2 mutation
Answer: D
Conceptual Explanation: PARP inhibitors utilize the concept of synthetic lethality in
tumors with deficient homologous recombination repair, most commonly due to BRCA1 or
BRCA2 mutations.
2. A patient receiving treatment with a CTLA-4 inhibitor presents with severe diarrhea and
abdominal pain. What is the most appropriate initial management for suspected Grade 3
immune-related colitis?
A. Loperamide 2mg every 4 hours
,B. Immediate administration of infliximab
C. High-dose intravenous corticosteroids (e.g., methylprednisolone 1-2 mg/kg/day)
D. Observation and oral rehydration
Answer: C
Conceptual Explanation: For Grade 3 immune-related colitis, corticosteroids are the first-
line treatment. Infliximab is reserved for steroid-refractory cases.
3. Which chemotherapy agent is most frequently associated with the development of
secondary acute myeloid leukemia (t-AML) involving 11q23 translocations?
A. Etoposide
B. Cisplatin
C. Cyclophosphamide
D. Methotrexate
Answer: A
Conceptual Explanation: Epipodophyllotoxins like etoposide are associated with a
shorter latency period to secondary AML, often involving the MLL gene at 11q23.
4. In the management of Tumor Lysis Syndrome (TLS), which medication is indicated for
patients at high risk or with existing hyperuricemia by converting uric acid to allantoin?
A. Rasburicase
B. Allopurinol
, C. Febuxostat
D. Sodium bicarbonate
Answer: A
Conceptual Explanation: Rasburicase is a recombinant urate oxidase enzyme that
converts poorly soluble uric acid into highly soluble allantoin.
5. A patient with metastatic non-small cell lung cancer (NSCLC) is found to have an ALK
rearrangement. Which targeted therapy is considered a preferred first-line treatment?
A. Osimertinib
B. Alectinib
C. Crizotinib
D. Erlotinib
Answer: B
Conceptual Explanation: Second-generation ALK inhibitors like Alectinib have shown
superior efficacy and CNS penetration compared to Crizotinib in the first-line setting.
6. What is the hallmark symptom of Syndrome of Inappropriate Antidiuretic Hormone
(SIADH) commonly seen in small cell lung cancer?
A. Euvolemic hyponatremia
B. Hypercalcemia
C. Hypokalemia
COMPREHENSIVE PRACTICE
QUESTIONS & VERIFIED ANSWERS (A+
GUARANTEE)
1. Which of the following molecular markers is a predictive biomarker for response to PARP
inhibitors in patients with ovarian or breast cancer?
A. HER2 amplification
B. EGFR T790M
C. KRAS mutation
D. BRCA1/2 mutation
Answer: D
Conceptual Explanation: PARP inhibitors utilize the concept of synthetic lethality in
tumors with deficient homologous recombination repair, most commonly due to BRCA1 or
BRCA2 mutations.
2. A patient receiving treatment with a CTLA-4 inhibitor presents with severe diarrhea and
abdominal pain. What is the most appropriate initial management for suspected Grade 3
immune-related colitis?
A. Loperamide 2mg every 4 hours
,B. Immediate administration of infliximab
C. High-dose intravenous corticosteroids (e.g., methylprednisolone 1-2 mg/kg/day)
D. Observation and oral rehydration
Answer: C
Conceptual Explanation: For Grade 3 immune-related colitis, corticosteroids are the first-
line treatment. Infliximab is reserved for steroid-refractory cases.
3. Which chemotherapy agent is most frequently associated with the development of
secondary acute myeloid leukemia (t-AML) involving 11q23 translocations?
A. Etoposide
B. Cisplatin
C. Cyclophosphamide
D. Methotrexate
Answer: A
Conceptual Explanation: Epipodophyllotoxins like etoposide are associated with a
shorter latency period to secondary AML, often involving the MLL gene at 11q23.
4. In the management of Tumor Lysis Syndrome (TLS), which medication is indicated for
patients at high risk or with existing hyperuricemia by converting uric acid to allantoin?
A. Rasburicase
B. Allopurinol
, C. Febuxostat
D. Sodium bicarbonate
Answer: A
Conceptual Explanation: Rasburicase is a recombinant urate oxidase enzyme that
converts poorly soluble uric acid into highly soluble allantoin.
5. A patient with metastatic non-small cell lung cancer (NSCLC) is found to have an ALK
rearrangement. Which targeted therapy is considered a preferred first-line treatment?
A. Osimertinib
B. Alectinib
C. Crizotinib
D. Erlotinib
Answer: B
Conceptual Explanation: Second-generation ALK inhibitors like Alectinib have shown
superior efficacy and CNS penetration compared to Crizotinib in the first-line setting.
6. What is the hallmark symptom of Syndrome of Inappropriate Antidiuretic Hormone
(SIADH) commonly seen in small cell lung cancer?
A. Euvolemic hyponatremia
B. Hypercalcemia
C. Hypokalemia
