AND CORRECT ANSWERS
Question:
1. Pharmacokinetics Definition
Answer:
how the body acts on the drug
Question:
2. Pharmacodynamics
Answer:
how the drug acts on the body
Question:
3. What is bioavailability? What determines bioavailability?
Answer:
How much of the drug reaches its target, and how long it exists there; ADME, physiological factors, route
of administration, and dietary factors
Question:
4. agonist
Answer:
A chemical that mimics the action of a neurotransmitter; e.g., a man pressing on a public tap for water to
come out at its maximum capacity.
Question:
5. partial agonist
Answer:
a drug that binds to a receptor and elicits a response less than that of a full agonist;
e.g., a child pressing a public tap for water to come out at a sub-maximal capacity.
Question:
6. inverse agonist
Answer:
A chemical substance binds to the same receptor as an agonist but induces a pharmacological response
opposite to that of the agonist; e.g., an officer lifting the tap up to prevent the water from coming out at all.
Question:
7. antagonist
Answer:
a molecule that inhibits or blocks a neurotransmitter's or an agonistic drug's action;
e.g., a caterpillar sitting on the tap blocks man, officer, and child from acting on the tap and doesn't start
the tap itself
, Question:
8. competitive antagonist
Answer:
binds to the same site as the agonist, reducing it's potency; e.g., narcan is an antagonist drug used to rapidly
reverse opioid overdoses by binding to opioid receptors. (competes with opioid)
Question:
9. noncompetitive antagonist
Answer:
binds to different (allosteric) sites or binds irreversibly, reducing the maximum efficacy, and cannot be
overcome by increased agonist concentration.
Question:
10. receptor definition
Answer:
location in the nervous system at which a neurotransmitter or a drug binds to exert its characteristic effect
(the tap)
Question:
11. ligand definition
Answer:
a molecule that binds to another (usually larger) molecule, i.e., receptor (child, man, caterpillar)
Question:
12. endogenous definition
Answer:
Produced within the body
Question:
13. somatic nervous system
Answer:
The division of the peripheral nervous system that controls voluntary activity of skeletal muscles
Question:
14. autonomic nervous system
Answer:
A subdivision of the peripheral nervous system. Controls the involuntary activity of visceral muscles and
internal organs, and glands.
Question:
15. sympathetic nervous system
Answer:
Branch of the autonomic nervous system that produces rapid physical arousal in response to perceived
emergencies or threats (fight or flight);
Question:
16. key brain systems involved in sympathetic nervous system?