WCU Pharmacology Week One
a drugs chemical name <CORRECT ANSWER>the name of the medication that reflects its
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chemical composition and molecular structure
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a drugs generic name <CORRECT ANSWER>the official or nonpropriety name the United
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States Adpoted Names Council gives a medication. Each medication only has one
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a drugs trade name <CORRECT ANSWER>the brand or proprietary name the company that
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manufactures the medication. Each medication can have multiple
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Identify the four components of pharmacokinetics <CORRECT ANSWER>absorption,
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distribution, metabolism, excretion
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excretion <CORRECT ANSWER>elimination of drugs from the body, is through the kidneys.
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Drugs are also excreted through bile, the lungs, saliva, sweat, and breast milk. The kidneys
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filter free drugs (in healthy kidneys, drugs bound to protein are not filtered), water-soluble
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drugs, and drugs that are unchanged. The lungs eliminate volatile drug substances, and
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products metabolize to carbon dioxide (CO2) and water (H2O).
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metabolism (biotransformation) <CORRECT ANSWER>changes medications into less active or
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inactive forms by the action of enzymes. This occurs primarily in the liver, but also takes
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place in the kidney, lungs, intestines, and blood.
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factors which influence metabolism <CORRECT ANSWER>age, metabolizing enzymes, first-pass
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effect, similar metabolic pathways, and nutritional status
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Distribution <CORRECT ANSWER>the transport of medication to sites of action by bodily
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fluids.
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, WCU Pharmacology Week One
Factors influencing distribution <CORRECT ANSWER>circulation, permeability of the cell
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membrane, and plasma protein binding
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absorption <CORRECT ANSWER>the transmission of medications from the location of
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administration to the blood stream. Most common routes administered are enteral and
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parenteral
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drug distribution <CORRECT ANSWER>the movement of the drug from the circulation to
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body tissues
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factors influencing drug distrubution <CORRECT ANSWER>the rate of blood flow to the
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tissue, the drug's affinity to the tissue, and protein binding.
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acidic drugs bind to <CORRECT ANSWER>albumin or lipoproteins
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basic drugs bind to <CORRECT ANSWER>alpha-1 glycoprotein (AGP)
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free drug <CORRECT ANSWER>not bound to protein, active and can cause a pharmacologic
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response
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When two highly protein bound drugs are given concurrently, they compete for ________
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binding sites, thus causing more ________ drug to be released into the circulation.
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<CORRECT ANSWER>protein, free
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factors which can alter protein binding includes <CORRECT ANSWER>low plasma levels which
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potentially decrease the number of available binding sites and can lead to an increase in the
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amount of free drug available, resulting in drug accumulation and toxicity
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a drugs chemical name <CORRECT ANSWER>the name of the medication that reflects its
nn nn nn nn nn nn nn nn nn nn nn nn
chemical composition and molecular structure
nn nn nn nn nn
a drugs generic name <CORRECT ANSWER>the official or nonpropriety name the United
nn nn nn nn nn nn nn nn nn nn nn
States Adpoted Names Council gives a medication. Each medication only has one
nn nn nn nn nn nn nn nn nn nn nn nn
a drugs trade name <CORRECT ANSWER>the brand or proprietary name the company that
nn nn nn nn nn nn nn nn nn nn nn nn
manufactures the medication. Each medication can have multiple
nn nn nn nn nn nn nn nn
Identify the four components of pharmacokinetics <CORRECT ANSWER>absorption,
nn nn nn nn nn nn nn
distribution, metabolism, excretion
nn nn nn
excretion <CORRECT ANSWER>elimination of drugs from the body, is through the kidneys.
nn nn nn nn nn nn nn nn nn nn nn
Drugs are also excreted through bile, the lungs, saliva, sweat, and breast milk. The kidneys
nn nn nn nn nn nn nn nn nn nn nn nn nn nn nn
filter free drugs (in healthy kidneys, drugs bound to protein are not filtered), water-soluble
nn nn nn nn nn nn nn nn nn nn nn nn nn nn
drugs, and drugs that are unchanged. The lungs eliminate volatile drug substances, and
nn nn nn nn nn nn nn nn nn nn nn nn nn
products metabolize to carbon dioxide (CO2) and water (H2O).
nn nn nn nn nn nn nn nn nn
metabolism (biotransformation) <CORRECT ANSWER>changes medications into less active or
nn nn nn nn nn nn nn nn
inactive forms by the action of enzymes. This occurs primarily in the liver, but also takes
nn nn nn nn nn nn nn nn nn nn nn nn nn nn nn nn
place in the kidney, lungs, intestines, and blood.
nn nn nn nn nn nn nn nn
factors which influence metabolism <CORRECT ANSWER>age, metabolizing enzymes, first-pass
nn nn nn nn nn nn nn nn
effect, similar metabolic pathways, and nutritional status
nn nn nn nn nn nn nn
Distribution <CORRECT ANSWER>the transport of medication to sites of action by bodily
nn nn nn nn nn nn nn nn nn nn nn
fluids.
nn
, WCU Pharmacology Week One
Factors influencing distribution <CORRECT ANSWER>circulation, permeability of the cell
nn nn nn nn nn nn nn nn
membrane, and plasma protein binding
nn nn nn nn nn
absorption <CORRECT ANSWER>the transmission of medications from the location of
nn nn nn nn nn nn nn nn nn
administration to the blood stream. Most common routes administered are enteral and
nn nn nn nn nn nn nn nn nn nn nn nn
parenteral
nn
drug distribution <CORRECT ANSWER>the movement of the drug from the circulation to
nn nn nn nn nn nn nn nn nn nn nn
body tissues
nn nn
factors influencing drug distrubution <CORRECT ANSWER>the rate of blood flow to the
nn nn nn nn nn nn nn nn nn nn nn
tissue, the drug's affinity to the tissue, and protein binding.
nn nn nn nn nn nn nn nn nn nn
acidic drugs bind to <CORRECT ANSWER>albumin or lipoproteins
nn nn nn nn nn nn nn
basic drugs bind to <CORRECT ANSWER>alpha-1 glycoprotein (AGP)
nn nn nn nn nn nn nn
free drug <CORRECT ANSWER>not bound to protein, active and can cause a pharmacologic
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response
nn
When two highly protein bound drugs are given concurrently, they compete for ________
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binding sites, thus causing more ________ drug to be released into the circulation.
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<CORRECT ANSWER>protein, free
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factors which can alter protein binding includes <CORRECT ANSWER>low plasma levels which
nn nn nn nn nn nn nn nn nn nn nn
potentially decrease the number of available binding sites and can lead to an increase in the
nn nn nn nn nn nn nn nn nn nn nn nn nn nn nn nn
amount of free drug available, resulting in drug accumulation and toxicity
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