Latent period is time between. Exposure of tissue to injurious agent and first appearance of signs
and symptoms (is also the time where it may disappear) exposure period
Prodromal period first signs and symptoms appear
Endemic definition localized to one particular area or group
Subclinical definition Going through treatment or management. patient functions normally; disease
processes are well established
Etiology topic in an example Known causes/ reasons of disease (behind the disease.)
idiopathic unknown cause
Latrogenic caused by treatment
Allostasis definition recognizes that body is out of homeostasis and allostasis brings the body back to
homeostasis.
Hormones that secretes during stress response catecholamines (epinephrine and norepinephrine) (also known as adrenaline) and
norepinephrine (also known as noradrenaline) Oxytocin, Prolactin, aldosterone &
cortisol Endorphins & Enkephalins
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Selye's three phases of stress Alarm
Resistance/adaptation
Exhaustion
Alarm fight or flight response
Resistance/adaptation Activity of the nervous and endocrine systems in returning the body to homeostasis
Exhaustion Point where body can no longer return to homeostasis
sympathetic nervous system mediated by norepinephrine sympathetic nervous system and adrenal medulla
secretes catecholamines ( epinephrine and norepinephrine) Cause things to hight
Plays a big part to stress response (blood pressure high ) Can cause blood to elevate
types of intracellular accumulations 1. normal endogenous constituent -(water, protein, lipid, carbohydrate) due to
inadequate removal (packaging, transport defects)=fatty liver (example)
2. Abnormal endogenous substance -due to genetic or acquired defects in folding,
packaging, transport, secretion =may lead to accumulation of proteins (a1 anti-trypsin
deficiency 3. Substrate, metabolite -due to inherited enzyme deficiencies and failure
to degrade = storage diseases 4. Abnormal exogenous substance -due to inability to
degrade and remove
cellular adaptation types Atrophy
Hypertrophy
Hyperplasia
Metaplasia
Dysplasia
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Atrophy Cells shrink and reduce their differentiated functions in response to normal and
injurious factors
Hypertrophy (increase in cell size) Increase in cell mass
Hyperplasia (increase in cells number ) Increase in functional capacity related to an increase in
cell number because of mitotic division
Metaplasia Replacement of one differentiated cell type with another common cause
Dysplasia (per cancerous) Disorganized appearance of cells because of abnormal variations in
size, shape, and arrangement Represents an adaptive effort gone astray Significant
potential to transform into cancerous cells (prenceplastic lesions)
Types of necrosis Coagulation
Liquefaction
Caseous
Fat
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