Test bank for Tietz Fundamentals of Clinical Chemistry and
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Molecular Diagnostics,
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8th Edition by Nader Rifai, PhD
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Chapters 1 - 49 fg fg fg fg
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
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Table of contents:
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I. Principles Of Laboratory Medicine
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Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
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Chapter 3. Clinical Evaluation of Methods
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Chapter 4. Evidence-Based Laboratory Medicine
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Chapter 5. Establishment and Use of Reference Values
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Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
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Chapter 7. Quality Management
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II. Analytical Techniques And Instrumentation
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Chapter 8. Principles of Basic Techniques and Laboratory Safety
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Chapter 9. Optical Techniques
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Chapter 10. Electrochemistry and Chemical Sensors
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Chapter 11. Electrophoresis
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Chapter 12. Chromatography
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Chapter 13. Mass Spectrometry
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Chapter 14. Enzyme and Rate Analyses
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Chapter 15. Immunochemical Techniques
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Chapter 16 Automation fg fg
Chapter 17. Point-of-Care Instrumentation
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III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
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Chapter 19. Serum Enzymes
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Chapter 20. Tumor Markers and Cancer Genes
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Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
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Chapter 22. Carbohydrates
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Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
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Chapter 24. Electrolytes and Blood Gases
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Chapter 25. Hormones fg fg
Chapter 26. Catecholamines and Serotonin
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Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
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Chapter 28. Hemoglobin, Iron, and Bilirubin
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Chapter 29. Porphyrins and Porphyrias
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Chapter 30. Therapeutic Drugs and Their Management
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Chapter 31. Clinical Toxicology
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Chapter 32. Toxic Metals
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IV. Pathophysiology
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Chapter 33. Diabetes fg fg
,Chapter 34. Cardiovascular Disease
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Chapter 35. Kidney Disease
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Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
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Chapter 37. Liver Disease
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Chapter 38. Gastrointestinal and Pancreatic Diseases
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Chapter 39. Disorders of Bone and Mineral Metabolism
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Chapter 40. Disorders of the Pituitary Gland
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Chapter 41. Disorders of the Adrenal Cortex
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Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
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Chapter 44. Pregnancy and Prenatal Testing
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Chapter 45. Newborn Screening and Inborn Errors of Metabolism
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Chapter 46. Pharmacogenetics
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V. Molecular Diagnostics
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Chapter 47. Principles of Molecular Biology
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Chapter 48. Nucleic Acid Techniques and Applications
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Chapter 49. Genomes and Nucleic Acid Alterations
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, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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TestBank
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MULTIPLE CHOICE fg
1. An individual working in a clinical chemistry laboratory is married to a sales representative
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who works for a company that sells chemistry laboratory supplies. When the laboratory
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manager requests a list of needed supplies, cost of supplies, and vendors, this individual
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onlyrecommends the spouse’s company as the vendor. This is considered to be a(n):
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a. accounting issue. fg
b. possible conflict of interest. fg fg fg
c. maintenance of confidentiality issue. fg fg fg
d. problem with resource allocation. fg fg fg
ANS: B fg
Concern has been raised over the interrelationships between practitioners in the medical
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fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
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Similarly, relationships have been scrutinized between clinical laboratorians and
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manufacturers and providers of diagnostic equipment and supplies. These concerns led the
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National Institutes of Health (NIH) in 1995 to require official institutional review of
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financial disclosure by researchers and management of situations in which disclosure
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indicates potentialconflicts of interest.
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DIF: 1 REF: Page 4-5 fg fg fg fg OBJ: 6 | 7 fg fg fg
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
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the pain following her recent surgery. A friend of the patient claims that the same
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painkiller―worked wonders‖ to reduce her pain after the same surgery. The physician
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states that the difference in the effect of the drug might be caused by , which is studied
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in pharmacogenetics.
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a. epidemiology
b. an inherited disease fg fg
c. a conflict of interestfg fg fg
d. a genetic variation in drug-metabolizing enzymes
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ANS: D fg
Pharmacogenetics is the study of the genetic variation of drug metabolism fg fg fg fg fg fg fg fg fg fg
betweenindividuals.
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DIF: 1 REF: Page 3 fg fg f g fg OBJ: 1 fg
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
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name of a close friend printed on the bar-coded label. The genetic test that is ordered on
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thefriend’s sample would provide diagnostic information about a disorder that has a poor
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prognosis, and the test is usually performed by John. He asks a fellow employee to
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analyzethe sample for him and not divulge the results. This ethical issue concerns:
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a. confidentiality of patient genetic and medical information. fg fg fg fg fg fg
b. a conflict of interest.
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c. resource allocation. fg
d. diagnostic accuracy. fg
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Molecular Diagnostics,
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8th Edition by Nader Rifai, PhD
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Chapters 1 - 49 fg fg fg fg
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
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fg
fg fg
Table of contents:
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I. Principles Of Laboratory Medicine
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Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
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Chapter 3. Clinical Evaluation of Methods
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Chapter 4. Evidence-Based Laboratory Medicine
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Chapter 5. Establishment and Use of Reference Values
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Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
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Chapter 7. Quality Management
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II. Analytical Techniques And Instrumentation
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Chapter 8. Principles of Basic Techniques and Laboratory Safety
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Chapter 9. Optical Techniques
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Chapter 10. Electrochemistry and Chemical Sensors
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Chapter 11. Electrophoresis
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Chapter 12. Chromatography
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Chapter 13. Mass Spectrometry
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Chapter 14. Enzyme and Rate Analyses
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Chapter 15. Immunochemical Techniques
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Chapter 16 Automation fg fg
Chapter 17. Point-of-Care Instrumentation
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III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
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Chapter 19. Serum Enzymes
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Chapter 20. Tumor Markers and Cancer Genes
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Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
fg fg fg fg fg fg fg fg fg fg fg
Chapter 22. Carbohydrates
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Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
fg fg fg fg fg fg fg fg fg
Chapter 24. Electrolytes and Blood Gases
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Chapter 25. Hormones fg fg
Chapter 26. Catecholamines and Serotonin
fg f g fg fg
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
fg f g fg fg fg fg
Chapter 28. Hemoglobin, Iron, and Bilirubin
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Chapter 29. Porphyrins and Porphyrias
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Chapter 30. Therapeutic Drugs and Their Management
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Chapter 31. Clinical Toxicology
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Chapter 32. Toxic Metals
fg f g fg
IV. Pathophysiology
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Chapter 33. Diabetes fg fg
,Chapter 34. Cardiovascular Disease
fg f g fg
Chapter 35. Kidney Disease
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Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
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Chapter 37. Liver Disease
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Chapter 38. Gastrointestinal and Pancreatic Diseases
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Chapter 39. Disorders of Bone and Mineral Metabolism
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Chapter 40. Disorders of the Pituitary Gland
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Chapter 41. Disorders of the Adrenal Cortex
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Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
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Chapter 44. Pregnancy and Prenatal Testing
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Chapter 45. Newborn Screening and Inborn Errors of Metabolism
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Chapter 46. Pharmacogenetics
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V. Molecular Diagnostics
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Chapter 47. Principles of Molecular Biology
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Chapter 48. Nucleic Acid Techniques and Applications
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Chapter 49. Genomes and Nucleic Acid Alterations
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, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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TestBank
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MULTIPLE CHOICE fg
1. An individual working in a clinical chemistry laboratory is married to a sales representative
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who works for a company that sells chemistry laboratory supplies. When the laboratory
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manager requests a list of needed supplies, cost of supplies, and vendors, this individual
fg fg fg fg fg fg fg fg fg fg fg fg fg fg
onlyrecommends the spouse’s company as the vendor. This is considered to be a(n):
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a. accounting issue. fg
b. possible conflict of interest. fg fg fg
c. maintenance of confidentiality issue. fg fg fg
d. problem with resource allocation. fg fg fg
ANS: B fg
Concern has been raised over the interrelationships between practitioners in the medical
fg fg fg fg fg fg fg fg fg fg fg
fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
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Similarly, relationships have been scrutinized between clinical laboratorians and
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manufacturers and providers of diagnostic equipment and supplies. These concerns led the
fg fg fg fg fg fg fg fg fg fg fg fg
National Institutes of Health (NIH) in 1995 to require official institutional review of
fg fg fg fg fg fg fg fg fg fg fg fg fg
financial disclosure by researchers and management of situations in which disclosure
fg fg fg fg fg fg fg fg fg fg fg
indicates potentialconflicts of interest.
fg fg fg fg fg
DIF: 1 REF: Page 4-5 fg fg fg fg OBJ: 6 | 7 fg fg fg
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
fg fg fg fg fg fg fg fg fg fg fg fg fg fg
the pain following her recent surgery. A friend of the patient claims that the same
fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg
painkiller―worked wonders‖ to reduce her pain after the same surgery. The physician
fg fg fg fg fg fg fg fg fg fg fg fg fg
states that the difference in the effect of the drug might be caused by , which is studied
fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg
in pharmacogenetics.
fg fg
a. epidemiology
b. an inherited disease fg fg
c. a conflict of interestfg fg fg
d. a genetic variation in drug-metabolizing enzymes
fg fg fg fg fg
ANS: D fg
Pharmacogenetics is the study of the genetic variation of drug metabolism fg fg fg fg fg fg fg fg fg fg
betweenindividuals.
fg fg
DIF: 1 REF: Page 3 fg fg f g fg OBJ: 1 fg
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
fg fg fg fg fg fg fg fg fg fg fg fg fg fg
name of a close friend printed on the bar-coded label. The genetic test that is ordered on
fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg
thefriend’s sample would provide diagnostic information about a disorder that has a poor
fg fg fg fg fg fg fg fg fg fg fg fg fg fg
prognosis, and the test is usually performed by John. He asks a fellow employee to
fg fg fg fg fg fg fg fg fg fg fg fg fg fg fg
analyzethe sample for him and not divulge the results. This ethical issue concerns:
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a. confidentiality of patient genetic and medical information. fg fg fg fg fg fg
b. a conflict of interest.
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c. resource allocation. fg
d. diagnostic accuracy. fg