ATI Capstone Exam 2 Summer 2026-2027 High-Yield
Practice Test Bank | Original Multiple-Choice
Questions & Detailed Clinical Rationales
Ace your summer nursing benchmarks and secure your graduation sign-off with this
high-yield ATI Capstone Exam 2 Summer 2026 practice test bank. Master complex,
multi-system nursing domains including advanced maternal-newborn emergencies,
high-risk adult medical-surgical alterations, critical psychopharmacology safety
protocols, and Next Generation NCLEX (NGN) clinical judgment models. Every
original multiple-choice question features a comprehensive clinical rationale designed to
sharpen your diagnostic reasoning and guarantee a top predictor score.
1. A nurse is assessing a client who has a new prescription for carvedilol. Which
finding indicates a therapeutic response?
A) Increased blood pressure
B) Decreased heart rate and blood pressure
C) Increased urine output
D) Decreased respiratory rate
Rationale: Carvedilol is a beta-blocker used to treat hypertension and heart failure. A
decrease in heart rate and blood pressure indicates a therapeutic response.
2. A nurse is caring for a client who has a new prescription for amiodarone. Which
finding requires immediate intervention?
A) Heart rate 72/min
B) Shortness of breath and cough
,C) Blood pressure 120/80 mm Hg
D) Dry mouth
Rationale: Amiodarone can cause pulmonary toxicity. Shortness of breath and cough
require immediate intervention, including holding the medication and notifying the
provider.
3. A nurse is providing teaching to a client who has a new prescription for
diltiazem. Which instruction should the nurse include?
A) "Take this medication with grapefruit juice."
B) "Avoid drinking grapefruit juice while taking this medication."
C) "Stop this medication if you feel better."
D) "Take this medication at bedtime only."
Rationale: Grapefruit juice can increase diltiazem levels and the risk of toxicity. Clients
should avoid it while taking this medication.
4. A nurse is assessing a client who has a new prescription for hydralazine. Which
finding indicates a serious adverse effect?
A) Headache
B) Joint pain and fever
C) Dizziness
D) Nausea
Rationale: Hydralazine can cause drug-induced lupus. Joint pain, fever, and rash require
immediate intervention and provider notification.
,5. A nurse is caring for a client who has a new prescription for clonidine. Which
instruction should the nurse include?
A) "Stop this medication if you feel better."
B) "Do not stop this medication abruptly."
C) "Take this medication with food."
D) "Take this medication at bedtime."
Rationale: Clonidine should not be stopped abruptly due to the risk of rebound
hypertension. It should be tapered gradually.
6. A nurse is assessing a client who has a new prescription for methyldopa. Which
finding indicates a therapeutic response?
A) Increased blood pressure
B) Decreased blood pressure
C) Increased heart rate
D) Decreased urine output
Rationale: Methyldopa is an antihypertensive used to treat hypertension, including in
pregnancy. Decreased blood pressure indicates a therapeutic response.
7. A nurse is providing teaching to a client who has a new prescription for
nitrofurantoin. Which instruction should the nurse include?
A) "Take this medication with food."
B) "Take this medication with food to reduce GI upset."
C) "Take this medication at bedtime."
D) "Stop this medication if you feel better."
, Rationale: Nitrofurantoin should be taken with food to reduce gastrointestinal side
effects. It is used to treat urinary tract infections.
8. A nurse is assessing a client who has a new prescription for ciprofloxacin. Which
finding indicates a serious adverse effect?
A) Nausea
B) Tendon pain and swelling
C) Diarrhea
D) Headache
Rationale: Ciprofloxacin can cause tendon rupture, especially in older adults and those
taking corticosteroids. Tendon pain and swelling require immediate intervention.
9. A nurse is caring for a client who has a new prescription for levofloxacin. Which
instruction should the nurse include?
A) "Take this medication with antacids."
B) "Avoid taking antacids within 2 hours of this medication."
C) "Take this medication with milk."
D) "Stop this medication if you feel better."
Rationale: Antacids and dairy products can interfere with the absorption of levofloxacin.
They should be taken at least 2 hours apart.
10. A nurse is assessing a client who has a new prescription for azithromycin.
Which finding indicates a therapeutic response?
Practice Test Bank | Original Multiple-Choice
Questions & Detailed Clinical Rationales
Ace your summer nursing benchmarks and secure your graduation sign-off with this
high-yield ATI Capstone Exam 2 Summer 2026 practice test bank. Master complex,
multi-system nursing domains including advanced maternal-newborn emergencies,
high-risk adult medical-surgical alterations, critical psychopharmacology safety
protocols, and Next Generation NCLEX (NGN) clinical judgment models. Every
original multiple-choice question features a comprehensive clinical rationale designed to
sharpen your diagnostic reasoning and guarantee a top predictor score.
1. A nurse is assessing a client who has a new prescription for carvedilol. Which
finding indicates a therapeutic response?
A) Increased blood pressure
B) Decreased heart rate and blood pressure
C) Increased urine output
D) Decreased respiratory rate
Rationale: Carvedilol is a beta-blocker used to treat hypertension and heart failure. A
decrease in heart rate and blood pressure indicates a therapeutic response.
2. A nurse is caring for a client who has a new prescription for amiodarone. Which
finding requires immediate intervention?
A) Heart rate 72/min
B) Shortness of breath and cough
,C) Blood pressure 120/80 mm Hg
D) Dry mouth
Rationale: Amiodarone can cause pulmonary toxicity. Shortness of breath and cough
require immediate intervention, including holding the medication and notifying the
provider.
3. A nurse is providing teaching to a client who has a new prescription for
diltiazem. Which instruction should the nurse include?
A) "Take this medication with grapefruit juice."
B) "Avoid drinking grapefruit juice while taking this medication."
C) "Stop this medication if you feel better."
D) "Take this medication at bedtime only."
Rationale: Grapefruit juice can increase diltiazem levels and the risk of toxicity. Clients
should avoid it while taking this medication.
4. A nurse is assessing a client who has a new prescription for hydralazine. Which
finding indicates a serious adverse effect?
A) Headache
B) Joint pain and fever
C) Dizziness
D) Nausea
Rationale: Hydralazine can cause drug-induced lupus. Joint pain, fever, and rash require
immediate intervention and provider notification.
,5. A nurse is caring for a client who has a new prescription for clonidine. Which
instruction should the nurse include?
A) "Stop this medication if you feel better."
B) "Do not stop this medication abruptly."
C) "Take this medication with food."
D) "Take this medication at bedtime."
Rationale: Clonidine should not be stopped abruptly due to the risk of rebound
hypertension. It should be tapered gradually.
6. A nurse is assessing a client who has a new prescription for methyldopa. Which
finding indicates a therapeutic response?
A) Increased blood pressure
B) Decreased blood pressure
C) Increased heart rate
D) Decreased urine output
Rationale: Methyldopa is an antihypertensive used to treat hypertension, including in
pregnancy. Decreased blood pressure indicates a therapeutic response.
7. A nurse is providing teaching to a client who has a new prescription for
nitrofurantoin. Which instruction should the nurse include?
A) "Take this medication with food."
B) "Take this medication with food to reduce GI upset."
C) "Take this medication at bedtime."
D) "Stop this medication if you feel better."
, Rationale: Nitrofurantoin should be taken with food to reduce gastrointestinal side
effects. It is used to treat urinary tract infections.
8. A nurse is assessing a client who has a new prescription for ciprofloxacin. Which
finding indicates a serious adverse effect?
A) Nausea
B) Tendon pain and swelling
C) Diarrhea
D) Headache
Rationale: Ciprofloxacin can cause tendon rupture, especially in older adults and those
taking corticosteroids. Tendon pain and swelling require immediate intervention.
9. A nurse is caring for a client who has a new prescription for levofloxacin. Which
instruction should the nurse include?
A) "Take this medication with antacids."
B) "Avoid taking antacids within 2 hours of this medication."
C) "Take this medication with milk."
D) "Stop this medication if you feel better."
Rationale: Antacids and dairy products can interfere with the absorption of levofloxacin.
They should be taken at least 2 hours apart.
10. A nurse is assessing a client who has a new prescription for azithromycin.
Which finding indicates a therapeutic response?
