WGU D116 ADVANCED
PHARMACOLOGY PRACTICE EXAM
QUESTIONS AND ANSWERS
1. A patient with chronic kidney disease is prescribed a drug that is primarily excreted via the
renal system. Which pharmacokinetic parameter is most significantly altered in this patient?
A. Half-life
B. Volume of distribution
C. Absorption rate
D. Protein binding
Answer: A
Conceptual Explanation: In renal impairment, the clearance of drugs excreted by the
kidneys decreases, leading to a prolonged half-life and increased risk of toxicity.
2. A patient taking Warfarin is started on Amiodarone. What interaction should the provider
anticipate?
A. Decreased INR due to CYP450 induction
B. No significant interaction
,C. Decreased anticoagulant effect due to competitive binding
D. Increased INR due to CYP450 inhibition
Answer: D
Conceptual Explanation: Amiodarone inhibits CYP2C9, the enzyme responsible for
metabolizing S-warfarin, leading to increased serum levels of warfarin and a higher INR.
3. Which of the following is a potential side effect of long-term Proton Pump Inhibitor (PPI)
use?
A. Vitamin B12 deficiency
B. Hypokalemia
C. Hypercalcemia
D. Metabolic alkalosis
Answer: A
Conceptual Explanation: PPIs increase gastric pH, which can impair the absorption of
Vitamin B12 and minerals like magnesium and calcium.
4. A patient is diagnosed with Heart Failure with Reduced Ejection Fraction (HFrEF). Which
medication class is contraindicated if the patient has a history of angioedema?
A. Beta-blockers
B. Loop diuretics
C. ACE Inhibitors
, D. Aldosterone antagonists
Answer: C
Conceptual Explanation: ACE inhibitors are contraindicated in patients with a history of
angioedema due to the accumulation of bradykinin.
5. Which mechanism of action describes how Metformin works in Type 2 Diabetes?
A. Stimulates insulin secretion from pancreatic beta cells
B. Decreases hepatic glucose production and increases insulin sensitivity
C. Increases glucose excretion through the kidneys
D. Delays carbohydrate absorption in the gut
Answer: B
Conceptual Explanation: Metformin primarily works by inhibiting gluconeogenesis in the
liver and improving peripheral glucose uptake.
6. What is the primary monitoring parameter for a patient starting Clozapine?
A. Serum creatinine
B. Liver function tests
C. Absolute Neutrophil Count (ANC)
D. Thyroid stimulating hormone
Answer: C
PHARMACOLOGY PRACTICE EXAM
QUESTIONS AND ANSWERS
1. A patient with chronic kidney disease is prescribed a drug that is primarily excreted via the
renal system. Which pharmacokinetic parameter is most significantly altered in this patient?
A. Half-life
B. Volume of distribution
C. Absorption rate
D. Protein binding
Answer: A
Conceptual Explanation: In renal impairment, the clearance of drugs excreted by the
kidneys decreases, leading to a prolonged half-life and increased risk of toxicity.
2. A patient taking Warfarin is started on Amiodarone. What interaction should the provider
anticipate?
A. Decreased INR due to CYP450 induction
B. No significant interaction
,C. Decreased anticoagulant effect due to competitive binding
D. Increased INR due to CYP450 inhibition
Answer: D
Conceptual Explanation: Amiodarone inhibits CYP2C9, the enzyme responsible for
metabolizing S-warfarin, leading to increased serum levels of warfarin and a higher INR.
3. Which of the following is a potential side effect of long-term Proton Pump Inhibitor (PPI)
use?
A. Vitamin B12 deficiency
B. Hypokalemia
C. Hypercalcemia
D. Metabolic alkalosis
Answer: A
Conceptual Explanation: PPIs increase gastric pH, which can impair the absorption of
Vitamin B12 and minerals like magnesium and calcium.
4. A patient is diagnosed with Heart Failure with Reduced Ejection Fraction (HFrEF). Which
medication class is contraindicated if the patient has a history of angioedema?
A. Beta-blockers
B. Loop diuretics
C. ACE Inhibitors
, D. Aldosterone antagonists
Answer: C
Conceptual Explanation: ACE inhibitors are contraindicated in patients with a history of
angioedema due to the accumulation of bradykinin.
5. Which mechanism of action describes how Metformin works in Type 2 Diabetes?
A. Stimulates insulin secretion from pancreatic beta cells
B. Decreases hepatic glucose production and increases insulin sensitivity
C. Increases glucose excretion through the kidneys
D. Delays carbohydrate absorption in the gut
Answer: B
Conceptual Explanation: Metformin primarily works by inhibiting gluconeogenesis in the
liver and improving peripheral glucose uptake.
6. What is the primary monitoring parameter for a patient starting Clozapine?
A. Serum creatinine
B. Liver function tests
C. Absolute Neutrophil Count (ANC)
D. Thyroid stimulating hormone
Answer: C
