ACUTE LYMPHOBLASTIC LEUKEMIA
ACTUAL TEST PAPER WITH VERIFIED
ANSWERS
●● what are 5 common signs and sxs of AML?
Answer: -weakness, fatigue, pallor
-fever, infections
-bleeding, bruising
-gingival infiltration
-hepatomegaly and splenomegaly
●● what are 4 demographic characteristics of AML?
Answer: -most common in adults
-median age at diagnosis is 69
-male predominance across all age groups
-dramatic increase in adults >/=40
●● what is the pathogenesis of AML?
Answer: clonal process resulting in an accumulation of abnormal
myeloid cells that are capable of dividing and proliferating, but not
differentiating into mature cells
, ●● what are 2 classes of AML mutations?
Answer: -class I: conferring a proliferative advantage
-class II: impairing hematopoietic differentiation
●● what are 3 diagnostic tools used for workup of AML?
Answer: -IHC or flow cytometry
-FISH
-PCR or next gen sequencing
●● what are auer rods and their significance?
Answer: -needle-like cytoplasmic inclusions containing fused primary
granules, pathognomonic for myeloid lineage
-presence strongly suggests AML
●● what are 2 fitness assessments used to decide between intensive and
low intensity therapy?
Answer: -ECOG performance status: 0-2 means fit for intensive therapy
-charlson comorbidity index (CCI): 0-2 means fit for intensive therapy
●● what is standard 7 + 3?
Answer: -cytarabine 100-200 mg/m2/day CIV for 7 days
-daunorubicin 60 or 90 mg/m2 or idarubicin 12 mg/m2 for 3 days
ACTUAL TEST PAPER WITH VERIFIED
ANSWERS
●● what are 5 common signs and sxs of AML?
Answer: -weakness, fatigue, pallor
-fever, infections
-bleeding, bruising
-gingival infiltration
-hepatomegaly and splenomegaly
●● what are 4 demographic characteristics of AML?
Answer: -most common in adults
-median age at diagnosis is 69
-male predominance across all age groups
-dramatic increase in adults >/=40
●● what is the pathogenesis of AML?
Answer: clonal process resulting in an accumulation of abnormal
myeloid cells that are capable of dividing and proliferating, but not
differentiating into mature cells
, ●● what are 2 classes of AML mutations?
Answer: -class I: conferring a proliferative advantage
-class II: impairing hematopoietic differentiation
●● what are 3 diagnostic tools used for workup of AML?
Answer: -IHC or flow cytometry
-FISH
-PCR or next gen sequencing
●● what are auer rods and their significance?
Answer: -needle-like cytoplasmic inclusions containing fused primary
granules, pathognomonic for myeloid lineage
-presence strongly suggests AML
●● what are 2 fitness assessments used to decide between intensive and
low intensity therapy?
Answer: -ECOG performance status: 0-2 means fit for intensive therapy
-charlson comorbidity index (CCI): 0-2 means fit for intensive therapy
●● what is standard 7 + 3?
Answer: -cytarabine 100-200 mg/m2/day CIV for 7 days
-daunorubicin 60 or 90 mg/m2 or idarubicin 12 mg/m2 for 3 days
