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CITI PRACTICE EXAM 2026/2027 | CITI
CERTIFICATIONS | 50 VERIFIED Q&A | DETAILED
RATIONALES | PASS GUARANTEED – A+ GRADED
SECTION 1: HUMAN SUBJECTS RESEARCH – Questions 1–15
Q1: CITI Program – Purpose
The student is reviewing the CITI Program. What is the primary purpose of the CITI Program?
A. To provide research ethics and compliance training for institutions and researchers
B. To fund clinical trials
C. To publish research articles
D. To regulate drug manufacturing
Correct Answer: A
Rationale: The Collaborative Institutional Training Initiative (CITI Program) provides web-based
training in research ethics, human subjects protections, animal care, responsible conduct of
research, and good clinical practice. [100% CORRECT]
Q2: Belmont Report – Respect for Persons
The student is reviewing the Belmont Report. Which principle requires that individuals be treated as
autonomous agents and that those with diminished autonomy be protected?
A. Respect for persons
B. Beneficence
C. Justice
D. Nonmaleficence
Correct Answer: A
Rationale: Respect for persons requires acknowledging autonomy and protecting individuals with
diminished autonomy, such as children or cognitively impaired persons. [100% CORRECT]
Q3: Belmont Report – Beneficence
The student is reviewing beneficence. What does beneficence require in human subjects research?
A. Maximizing benefits and minimizing harms
B. Fair distribution of burdens and benefits
C. Obtaining informed consent
D. Protecting privacy
Correct Answer: A
Rationale: Beneficence requires researchers to maximize possible benefits and minimize possible
harms. It involves a risk-benefit assessment. [100% CORRECT]
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Q4: Belmont Report – Justice
The student is reviewing justice. What does justice require in human subjects research?
A. Fair and equitable selection of subjects
B. Maximizing benefits
C. Respecting autonomy
D. Avoiding harm
Correct Answer: A
Rationale: Justice requires fair distribution of the burdens and benefits of research. Subjects should
not be selected merely because they are easy to reach or vulnerable. [100% CORRECT]
Q5: IRB – Primary Function
The student is reviewing the IRB. What is the primary function of an Institutional Review Board
(IRB)?
A. To protect the rights and welfare of human research subjects
B. To fund research
C. To analyze data
D. To publish results
Correct Answer: A
Rationale: The IRB reviews research involving human subjects to ensure that risks are minimized,
informed consent is obtained, and subject rights and welfare are protected. [100% CORRECT]
Q6: IRB – Review Categories
The student is reviewing IRB review. Which type of review involves no more than minimal risk and is
conducted by the IRB chair or designee?
A. Exempt review
B. Expedited review
C. Full board review
D. Continuing review
Correct Answer: B
Rationale: Expedited review is for research involving no more than minimal risk and falling into
specified categories. It is conducted by the IRB chair or designated member(s). [100% CORRECT]
Q7: IRB – Full Board Review
The student is reviewing full board review. When is full board review required?
A. When research involves greater than minimal risk
B. When research is exempt
C. When research is expedited
D. When research involves only surveys
Correct Answer: A
Rationale: Full board review is required for research involving greater than minimal risk or
vulnerable populations where additional protections are needed. [100% CORRECT]
CITI PRACTICE EXAM 2026/2027 | CITI
CERTIFICATIONS | 50 VERIFIED Q&A | DETAILED
RATIONALES | PASS GUARANTEED – A+ GRADED
SECTION 1: HUMAN SUBJECTS RESEARCH – Questions 1–15
Q1: CITI Program – Purpose
The student is reviewing the CITI Program. What is the primary purpose of the CITI Program?
A. To provide research ethics and compliance training for institutions and researchers
B. To fund clinical trials
C. To publish research articles
D. To regulate drug manufacturing
Correct Answer: A
Rationale: The Collaborative Institutional Training Initiative (CITI Program) provides web-based
training in research ethics, human subjects protections, animal care, responsible conduct of
research, and good clinical practice. [100% CORRECT]
Q2: Belmont Report – Respect for Persons
The student is reviewing the Belmont Report. Which principle requires that individuals be treated as
autonomous agents and that those with diminished autonomy be protected?
A. Respect for persons
B. Beneficence
C. Justice
D. Nonmaleficence
Correct Answer: A
Rationale: Respect for persons requires acknowledging autonomy and protecting individuals with
diminished autonomy, such as children or cognitively impaired persons. [100% CORRECT]
Q3: Belmont Report – Beneficence
The student is reviewing beneficence. What does beneficence require in human subjects research?
A. Maximizing benefits and minimizing harms
B. Fair distribution of burdens and benefits
C. Obtaining informed consent
D. Protecting privacy
Correct Answer: A
Rationale: Beneficence requires researchers to maximize possible benefits and minimize possible
harms. It involves a risk-benefit assessment. [100% CORRECT]
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Q4: Belmont Report – Justice
The student is reviewing justice. What does justice require in human subjects research?
A. Fair and equitable selection of subjects
B. Maximizing benefits
C. Respecting autonomy
D. Avoiding harm
Correct Answer: A
Rationale: Justice requires fair distribution of the burdens and benefits of research. Subjects should
not be selected merely because they are easy to reach or vulnerable. [100% CORRECT]
Q5: IRB – Primary Function
The student is reviewing the IRB. What is the primary function of an Institutional Review Board
(IRB)?
A. To protect the rights and welfare of human research subjects
B. To fund research
C. To analyze data
D. To publish results
Correct Answer: A
Rationale: The IRB reviews research involving human subjects to ensure that risks are minimized,
informed consent is obtained, and subject rights and welfare are protected. [100% CORRECT]
Q6: IRB – Review Categories
The student is reviewing IRB review. Which type of review involves no more than minimal risk and is
conducted by the IRB chair or designee?
A. Exempt review
B. Expedited review
C. Full board review
D. Continuing review
Correct Answer: B
Rationale: Expedited review is for research involving no more than minimal risk and falling into
specified categories. It is conducted by the IRB chair or designated member(s). [100% CORRECT]
Q7: IRB – Full Board Review
The student is reviewing full board review. When is full board review required?
A. When research involves greater than minimal risk
B. When research is exempt
C. When research is expedited
D. When research involves only surveys
Correct Answer: A
Rationale: Full board review is required for research involving greater than minimal risk or
vulnerable populations where additional protections are needed. [100% CORRECT]
