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HESI A2 Anatomy & Physiology Practice Test Questions: Human Anatomy, Physiology, Body Systems, Musculoskeletal, Nervous, Endocrine, Reproductive, Digestive, Urinary & Cardiovascular Systems – A+ Graded Answers – Updated 2026/2027 – Instant Download

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HESI A2 Anatomy & Physiology Practice Test Questions with A+ Graded Answers covering high-yield concepts for the HESI A2 Anatomy and Physiology assessment and foundational anatomy coursework. This comprehensive review includes homeostasis, anatomical position and terminology, histology, integumentary system, keratin, blood and erythropoiesis, skeletal anatomy, axial and appendicular skeleton, long bone anatomy, epiphysis, muscular system, sarcomeres, myofibrils, muscle contraction, ATP, major muscles, nervous system, neurons, dendrites and axons, medulla oblongata, spinal reflexes, spinal nerves, endocrine system, hormones, tropic hormones, cortisol, reproductive hormones, estrogen, progesterone, LH and FSH, ovulation, male reproductive anatomy, digestive tract, mastication, peristalsis, respiratory system, external respiration, diaphragm and inhalation, urinary system, ureters, kidneys and urine production, cardiovascular system, EKG electrical activity, sweat glands, vitamin K, and essential body-system relationships. Ideal for HESI A2 preparation, nursing school entrance exams, anatomy and physiology review, pre-nursing coursework, health science students, and students seeking focused coverage of frequently tested A&P concepts. Includes Ivy Tech Community College APHY 101-related anatomy and physiology content and is structured for efficient review of definitions, functions, anatomical structures, physiological processes, and exam-focused concepts.

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Ivy Tech Community College APHY 101




HESI A2 Practice test questions
With A+ Graded Answers Latest
Updated 2026


Which of the following is NOT a function of the b) to perform gas exchange
digestive tract?
a) to use enzymes to break down food Gas exchange is a function of the respiratory system
b) to perform gas exchange
c) to remove waste from the body
d) to use peristalsis to move food along


The body, at all times, attempts to maintain a) a process that maintains the stability of the human body's internal
homeostasis. The best definition of homeostasis is: environment in response to changes in internal and external
conditions
a) a process that maintains the stability of the human
body's internal environment in response to changes
in internal and external conditions
b) a function via which the body breaks down glucose
to use as energy
c) a process that maintains the immune
system's defenses
d) a process in which the body resists change
to genetic structure

The endocrine system of the body is responsible for: b) communication through the use of hormones
a) defense through the use of antibodies
b) communication through the use of hormones
c) metabolism through the use of enzymes
d) blood flow through the use of the heart muscle



Anatomical position shows the body in a(n) ________ c) anterior
position.
a) lateral
b) superior
c) anterior
d) posterior


Vitamin K is created in the: c) intestinal tract
a) liver
b) lungs
c) intestinal tract
d) pancreas

, The largest organ in the body is the ________. a) skin
a) skin
b) GI tract
c) femur
d) stomach


A medical scientists wants to study the parenchyma of d)
histologist the kidney. This scientist would correctly be known,
most specifically, as a: Histology is the study of tissues.
a) biologist
b) doctor
c) anatomist
d) histologist


What is Erythropoiesis? a) red blood cell formation
a) red blood cell formation
b) white blood cell formation Blood cell formation is called Hemopoiesis.
c) the destruction of red blood cells Erythro- red blood cells
d) the destruction of white blood cells


In which part of the body is keratin NOT found? d) teeth
a) hair
b) skin Keratin is a family of fibrous structural proteins. Keratin is the key structural
c) nails component of hair, nails, and the outer layer of human skin
d) teeth


What is the relationship between sarcomeres and c) muscle cells contain myofibrils, which in turn are made up of sarcomeres
muscle cells?
a) sarcomeres are muscle cells
b) sarcomeres contain muscle cells
c) muscle cells contain myofibrils, which in turn
are made up of sarcomeres
d) muscle cells contain sarcomeres, which in turn
are made up of myofibrils



A person who has torn their vastus lateralis muscle will b) a cane or crutches
need which of the following?
a) an arm sling The vastus lateralis muscle is a voluntary muscle in the legs. It is part of the
b) a cane or crutches quadriceps.
c) insulin
d) a neck brace


Muscles produce contraction due to the sliding of: a) filaments
a) filaments
b) sarcomeres During muscle contraction, filaments slide together by using energy supplied
c) flexors by ATP.
d) neutrons



The medulla oblongata has what primary responsibility? c) vital functions
a) balance
b) intellect The medulla oblongata is responsible for basic vital functions, including
c) vital functions respiration and heart rate.
d) sensory input

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