Test Bank For Cellular and Molecular Immunology, 11th Edition by Abul K. Abbas| Verified Chapters 1-21|| Latest Edition 2025 ISBN:978-0443283581

,Table of Contents
m2 m2




Chapter 01 Properties and Overview of Immune Responses
m2 m2 m2 m2 m2 m2 m2 1
Chapter 02 Cells and Tissues of the Immune System
m2 m2 m2 m2 m2 m2 m2 m2 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
m2 m 2 m2 m 2 m2 m2 m 2 6
Chapter 04 Innate Immunity
m2 m 2 m 2 10
Chapter 05 Antibodies and Antigens
m2 m 2 m2 m 2 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
m2 m2 m2 m 2 m2 m 2 m 2 m2 m2 m 2 m2



Histocompatibility Complex Molecules
m2 m 2 20
Chapter 07 Immune Receptors and Signal Transduction
m2 m2 m2 m2 m2 m2 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
m2 m2 m2 m 2 m2 m2 m2 m2 30
Chapter 09 Activation of T Lymphocytes
m2 m 2 m 2 m 2 m 2 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
m2 m 2 m 2 m 2 m2 m2 m2 m2 m2 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
m2 m 2 m 2 m 2 m2 m2 m2 m2 m2 42
Chapter 12 B Cell Activation and Antibody Production
m2 m 2 m2 m 2 m 2 m 2 m2 46
Chapter 13 Effector Mechanisms of Humoral Immunity
m2 m2 m2 m2 m2 m 2 52
Chapter
m2 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
m2 m 2 m2 m2 m2 m2 m2 m 2 m2 m 2 56
Chapter
m2 15 Immunologic Tolerance and Autoimmunity
m2 m2 m2 m2 62
Chapter
m2 16 Immunity to Microbes
m 2 m2 m 2 67
Chapter
m2 17 Transplantation Immunology
m 2 m 2 72
Chapter
m2 18 Tumor Immunology
m 2 m 2 77
Chapter
m2 19 Hypersensitivity Disorders
m 2 m2 81
Chapter 20 Allergy
m2 m 2 86
Chapter 21 Primary and Acquired
m2 m 2 m2 m 2 m 2 Immunodeficiencies 89

,Chapter 01: Properties and Overview of Immune Responses
m2 m2 m2 m2 m2 m2 m2


Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 11th Edition
m2 m2 m2 m2 m2 m2 m2 m2 m2




MULTIPLE CHOICE m2




1. The principal function of the immune system is:
m2 m2 m2 m2 m2 m2 m2


a. Defense against cancer m2 m2


b. Repair of injured tissues m2 m2 m2


c. Defense against microbial infections m2 m2 m2


d. Prevention of inflammatory diseases m2 m2 m2


e. Protection against environmental toxins m2 m2 m2




ANS: C
The immune system has evolved in the setting of selective pressures imposed by mic
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


robi al infections. Although immune responses to cancer may occur, the concept that
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 hx



“immun o m2


surveillance” against cancer is a principal function of the immune system is controvers
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


i al. Repair of injured tissues may be a secondary consequence of the immune respo
m 2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


nses a m2


nd i m2


nflammation. Although the immune system has regulatory features that are needed to
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


prev ent excessive inflammation, prevention of inflammatory diseases is not a primary
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


fu nction. The immune system can protect against microbial toxins, but it generally d
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


oes not offer pr otection against toxins of nonbiologic origin.
m2 m2 m2 m2 m2 m2 m2 m2 m2




2. Which of the following infectious diseases was prevented by the first suc
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


cessf ul vaccination?m2 m2


a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


a g ainst smallpox in a boy, using material from the cowpox pustules of a milkm
m 2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


aid. In 1980 m 2 m2


, smallpox was reported to be eradicated worldwide by a vaccination program. Effective
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


m 2va ccines against tetanus toxin, rubella virus, and poliovirus were developed in the 2
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


0th c ent ury and are widely used. There is no effective vaccine against Mycobacteriu
m2 m 2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


m tuberc ulosis.
m2 m2




3. Which of the following is a unique property of the adaptive immune system?
m2 m2 m2 m2 m 2 m2 m2 m2 m2 m2 m2 m2


a. Highly diverse repertoire of specificities for antigens
m2 m2 m2 m2 m2 m2


b. Self-nonself discrimination m2


c. Recognition of microbial structures by both cell-associated and soluble receptors
m2 m2 m2 m2 m2 m2 m2 m2 m2


d. Protection against viral infections m2 m2 m2


e. Responses that have the same kinetics and magnitude on repeated exposure
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


to t he same microbe
m2 m2 m2 m2 m2




ANS: A

, Highly diverse repertoires of specificities for antigens are found only in T and B lymp
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


ho cy tes, which are the central cellular components of the adaptive immune
m2 m2 m 2 m 2 m 2 m 2 m 2 m 2 m 2 m 2 m 2 m 2 m2


system. Both th e innate and the adaptive immune systems use cell-
m 2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


associated and soluble receptors to recognize microbes, display some degree o
m2 m2 m2 m 2 m 2 m2 m 2 m 2 m 2 m2


f self-
m2


nonself discrimination, and protect against viruses. On repeated exposure to the same
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m


mi c robe, the adaptive immune response becomes more rapid and of greater magnit
2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


ude; this m2


i
s the manifestation of memory.
m2 m2 m2 m2 m2




4. Antibodies and T lymphocytes are the respective mediators of which two t
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


ypes of immunity?
m2 m2


a. Innate and adaptive m2 m2


b. Passive and active m2 m2


c. Specific and nonspecific m2 m2


d. Humoral and cell-mediated m2 m2


e. Adult and neonatal m2 m2




ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B l
m 2 m2 m 2 m2 m 2 m 2 m 2 m 2 m2 m 2 m 2 m2


ymphocy te s produce antibodies, which are the recognition and effector molecules of
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


humoral im mun e responses to extracellular pathogens. T cells recognize and promote
m2 m 2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


eradication of int rac ellular pathogens in cell-
m2 m2 m2 m2 m2 m2 m2 m2


mediated immunity. Passive and active immunity both can be mediated by either B or
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


T ly mphocytes. Specific immunity is another term for adaptive immunity. Both B an
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


d T lymp h ocytes participate in adult adaptive immunity but are still developing in
m2 m2 m 2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


the neonatal peri o d.
m2 m2 m 2 m2




5. The two major functional classes of effector T lymphocytes are:
m2 m2 m2 m 2 m2 m2 m2 m2 m2


a. Helper T lymphocytes and cytotoxic T lymphocytes
m2 m2 m2 m2 m2 m2


b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mM
ph.oW
m2 cyStes m2 m2 m2


c. Memory T cells and effector T cells m2 m2 m2 m2 m2 m2


d. Helper cells and antigen-presenting cells
m2 m2 m2 m2


e. Cytotoxic T lymphocytes and target cells m2 m2 m2 m2 m2




ANS: A
T cells can be classified into effector subsets that perform different effector functions.
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


Mo s t effector T cells are either helper T lymphocytes, which enhance the responses
m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m


of other im mune cells, including phagocytes and B cells, to infections, or cytotoxic
2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


T lymphocyt
m2


es, m2


which directly kill infected cells. Natural killer cells are not T lympho
m 2 m 2 m 2 m 2 m 2 m 2 m 2 m 2 m 2 m 2 m 2


cytes.
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells.
hx m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 hxm2 m2 m2




6. Which of the following cell types is required for all adaptive humoral immune responses?
hx m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2 m2


a. Natural killer cells m2 m2


b. Dendritic cells m2


c. Cytolytic T lymphocytes m2 m2


d. B lymphocytes m2


e. Helper T lymphocytes m2 m2




ANS: D