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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
by Geralyn Frandsen EdD RN, SANDRA PENNINGTON || LATEST EDITION
13th Edition
,Table of Contents
Section 1: the conceptual framework of pharmacology ......................... 5
Chapter 1: the foundation of pharmacology: quality and safety ............................................... 5
Chapter 2: basic concepts and processes ................................................................................ 14
Chapter 3: medication administration and the nursing process of drug therapy ................... 23
Section 2: drug therapy throughout the lifespan ................................... 33
Chapter 4: pharmacology and the care of infants and pediatric patients medication
administration in pediatrics ...................................................................................................... 33
Chapter 5: Pharmacology and the Care of Adults and Geriatric Patients ................................ 42
Chapter 6: Pharmacology and the Care of Pregnant or Lactating Females ............................. 50
Chapter 7: Pharmacology and Female Health ......................................................................... 59
chapter 8: Pharmacology and Male Health .............................................................................. 70
Section 3: drugs affecting the hematopoietic and immune systems ... 79
Chapter 9: drug therapy for coagulation disorders.................................................................. 79
Chapter 10: drug therapy for dyslipidemia .............................................................................. 89
Chapter 11: drug therapy for hematopoietic disorders ........................................................... 98
Chapter 12: drug therapy: immunizations ............................................................................. 107
Chapter 13: drug therapy to decrease immunity................................................................... 116
Chapter 14: drug therapy for the treatment of cancer .......................................................... 125
Section 4: drugs affecting inflammation and infection ....................... 135
Chapter 15: inflammation, infection, and the use of antimicrobial agents ........................... 135
Chapter 16: drug therapy to decrease pain, fever, and inflammation ................................... 145
Chapter 17: drug therapy with corticosteroids ...................................................................... 155
Chapter 18: drug therapy with beta-lactam antibacterial agents ......................................... 165
Chapter 19: drug therapy with aminoglycosides and fluoroquinolones ............................... 174
Chapter 20: drug therapy with tetracyclines, sulfonamides, and urinary antiseptics ........... 183
Chapter 21: drug therapy with macrolides and miscellaneous anti-infective agents ........... 190
Chapter 22: drug therapy for tuberculosis and mycobacterium avium complex disease ..... 199
Chapter 23: drug therapy for viral infections ......................................................................... 209
, Chapter 24: drug therapy for fungal infections ...................................................................... 219
Chapter 25: drug therapy for parasitic infections .................................................................. 228
Section 5: drug affecting the cardiovascular system ......................... 237
Chapter 26: drug therapy for hypertension ........................................................................... 237
Chapter 27: drug therapy for dysrhythmias............................................................................ 246
Chapter 28: drug therapy for coronary heart disease ........................................................... 256
Chapter 29: drug therapy for shock and hypotension ........................................................... 266
Chapter 30: drug therapy for heart failure ............................................................................ 275
Section 6: drugs affecting the respiratory system .............................. 285
Chapter 31: drug therapy for nasal congestion and cough .................................................... 285
Chapter 32: drug therapy to decrease histamine effects and allergic response ................... 295
Chapter 33: drug therapy for asthma and bronchoconstriction ............................................ 304
Section 7: drugs affecting the renal and digestive systems ............... 313
Chapter 34: drug therapy for fluid volume excess ................................................................. 313
Chapter 35: nutritional support products, vitamins, and mineral supplements ................... 322
Chapter 36: drug therapy for weight management ............................................................... 331
Chapter 37: drug therapy for peptic ulcer disease and hyperacidity .................................... 340
Chapter 38: drug therapy for nausea and vomiting ............................................................... 348
Chapter 39: drug therapy for constipation and elimination problems .................................. 356
Chapter 40: drug therapy for diarrhea ................................................................................... 365
Section 8: drugs affecting the endocrine system ................................ 374
Chapter 41: drug therapy for diabetes mellitus ..................................................................... 374
Chapter 42: drug therapy for hyperthyroidism and hypothyroidism .................................... 384
Chapter 43: drug therapy for pituitary and hypothalamic dysfunction ................................. 393
Chapter 44: drug therapy to regulate calcium and bone metabolism ................................... 402
Chapter 45: drug therapy for addison's disease and cushing's disease ................................ 411
Section 9: drugs affecting the autonomic and central nervous system
............................................................................................................... 418
, Chapter 46: physiology of the autonomic and central nervous systems and indications for the
use of drug therapy ................................................................................................................. 418
Chapter 47: drug therapy for myasthenia gravis, alzheimer's disease, and urinary retention
................................................................................................................................................. 428
Chapter 48: drug therapy for parkinson's disease, urinary spasticity, and disorders requiring
anticholinergic drug therapy ................................................................................................... 438
Chapter 49: drug therapy with opioids .................................................................................. 448
Chapter 50: drug therapy with local anesthetics ................................................................... 457
Chapter 51: drug therapy with general anesthetics .............................................................. 464
Chapter 52: drug therapy for migraines and other headaches ............................................. 470
Chapter 53: drug therapy for seizure disorders and spasticity .............................................. 477
Chapter 54: drug therapy for anxiety and insomnia .............................................................. 486
Chapter 55: drug therapy for depression and mood stabilization ......................................... 496
Chapter 56: drug therapy for psychotic disorders ................................................................. 506
Chapter 57: drug therapy for attention deficit hyperactivity disorder and narcolepsy ......... 516
Chapter 58: drug therapy for substance abuse disorders ...................................................... 525
Section 10: drugs affecting the eye, ear, and skin .............................. 535
Chapter 59: drug therapy for disorders of the eye ................................................................ 535
Chapter 60: drug therapy for disorders of the ear................................................................. 544
Chapter 61: drug therapy for disorders of the skin ............................................................... 552
,Section 1: the conceptual framework of pharmacology
Chapter 1: the foundation of pharmacology: quality and safety
1. A woman has been prescribed paroxetine hydrochloride, which is an antidepressant
agent administered in pill form. The medication is administered for her obsessive- compulsive
disorder. This medication will produce which of the following effects?
A) curative
B) systemic
C) local
D) parenteral
Answer: b
Feedback: drugs that produce systemic effects are taken into the body, circulated through the
bloodstream to their sites of action in various body tissues, and eventually eliminated from the
body. Curative agents are given to cure a disease process. In this case, paroxetine hydrochloride
will control the symptoms but not cure the disorder. Drugs with local effects, such as sunscreen
and local anesthetics, act mainly at the site of application. Paroxetine hydrochloride is not
administered parenterally. Parenteral agents are administered subcutaneously, intramuscularly,
or intravenously.
2. A patient has been prescribed an antibiotic. This medication is a naturally occurring
substance that has been chemically modified. What is another name for this type of
medication?
A) synthetic drug
B) semisynthetic drug
C) biotechnology drug
D) prototype drug
Answer: b
Feedback: semisynthetic drugs (e.g., many antibiotics) are naturally occurring substances that
have been chemically modified. Synthetic drugs are more standardized in their chemical
, characteristics, more consistent in their effects, and less likely to produce allergic reactions.
Biotechnology drugs involve manipulating dna and rna and recombining genes into hybrid
molecules that can be inserted into living organisms. Prototype drugs are the first drug of a
particular group to be developed.
3. A patient is administered morphine. Morphine is a prototypical drug that can be
classified in different ways. Which of the following classifications applies to morphine?
A) central nervous system depressant
B) central nervous system stimulant
C) anti-inflammatory
D) antihypertensive
Answer: a
Feedback: drugs are classified according to their effects on particular body systems, their
therapeutic uses, and their chemical characteristics. For example, morphine can be classified as
a central nervous system depressant and a narcotic or opioid analgesic. A central nervous
system stimulant increases attention and raises mood. An anti-inflammatory agent decreases
inflammation at the site of tissue or joint inflammation. An antihypertensive agent reduces
blood pressure.
4. A patient is administered amoxicillin (amoxil). The generic name of this medication
indicates that it belongs to which drug group?
A) selective serotonin reuptake inhibitors
B) diuretics
C) penicillin’s
D) ace inhibitors
Answer: c
Feedback: the generic name often indicates the drug group (e.g., drugs with generic names
ending in “cillin” are penicillins). Selective serotonin reuptake inhibitors are medications that
have antidepressant effects; ssri is a broad classification, not a generic name. Diuretics are
Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
by Geralyn Frandsen EdD RN, SANDRA PENNINGTON || LATEST EDITION
13th Edition
,Table of Contents
Section 1: the conceptual framework of pharmacology ......................... 5
Chapter 1: the foundation of pharmacology: quality and safety ............................................... 5
Chapter 2: basic concepts and processes ................................................................................ 14
Chapter 3: medication administration and the nursing process of drug therapy ................... 23
Section 2: drug therapy throughout the lifespan ................................... 33
Chapter 4: pharmacology and the care of infants and pediatric patients medication
administration in pediatrics ...................................................................................................... 33
Chapter 5: Pharmacology and the Care of Adults and Geriatric Patients ................................ 42
Chapter 6: Pharmacology and the Care of Pregnant or Lactating Females ............................. 50
Chapter 7: Pharmacology and Female Health ......................................................................... 59
chapter 8: Pharmacology and Male Health .............................................................................. 70
Section 3: drugs affecting the hematopoietic and immune systems ... 79
Chapter 9: drug therapy for coagulation disorders.................................................................. 79
Chapter 10: drug therapy for dyslipidemia .............................................................................. 89
Chapter 11: drug therapy for hematopoietic disorders ........................................................... 98
Chapter 12: drug therapy: immunizations ............................................................................. 107
Chapter 13: drug therapy to decrease immunity................................................................... 116
Chapter 14: drug therapy for the treatment of cancer .......................................................... 125
Section 4: drugs affecting inflammation and infection ....................... 135
Chapter 15: inflammation, infection, and the use of antimicrobial agents ........................... 135
Chapter 16: drug therapy to decrease pain, fever, and inflammation ................................... 145
Chapter 17: drug therapy with corticosteroids ...................................................................... 155
Chapter 18: drug therapy with beta-lactam antibacterial agents ......................................... 165
Chapter 19: drug therapy with aminoglycosides and fluoroquinolones ............................... 174
Chapter 20: drug therapy with tetracyclines, sulfonamides, and urinary antiseptics ........... 183
Chapter 21: drug therapy with macrolides and miscellaneous anti-infective agents ........... 190
Chapter 22: drug therapy for tuberculosis and mycobacterium avium complex disease ..... 199
Chapter 23: drug therapy for viral infections ......................................................................... 209
, Chapter 24: drug therapy for fungal infections ...................................................................... 219
Chapter 25: drug therapy for parasitic infections .................................................................. 228
Section 5: drug affecting the cardiovascular system ......................... 237
Chapter 26: drug therapy for hypertension ........................................................................... 237
Chapter 27: drug therapy for dysrhythmias............................................................................ 246
Chapter 28: drug therapy for coronary heart disease ........................................................... 256
Chapter 29: drug therapy for shock and hypotension ........................................................... 266
Chapter 30: drug therapy for heart failure ............................................................................ 275
Section 6: drugs affecting the respiratory system .............................. 285
Chapter 31: drug therapy for nasal congestion and cough .................................................... 285
Chapter 32: drug therapy to decrease histamine effects and allergic response ................... 295
Chapter 33: drug therapy for asthma and bronchoconstriction ............................................ 304
Section 7: drugs affecting the renal and digestive systems ............... 313
Chapter 34: drug therapy for fluid volume excess ................................................................. 313
Chapter 35: nutritional support products, vitamins, and mineral supplements ................... 322
Chapter 36: drug therapy for weight management ............................................................... 331
Chapter 37: drug therapy for peptic ulcer disease and hyperacidity .................................... 340
Chapter 38: drug therapy for nausea and vomiting ............................................................... 348
Chapter 39: drug therapy for constipation and elimination problems .................................. 356
Chapter 40: drug therapy for diarrhea ................................................................................... 365
Section 8: drugs affecting the endocrine system ................................ 374
Chapter 41: drug therapy for diabetes mellitus ..................................................................... 374
Chapter 42: drug therapy for hyperthyroidism and hypothyroidism .................................... 384
Chapter 43: drug therapy for pituitary and hypothalamic dysfunction ................................. 393
Chapter 44: drug therapy to regulate calcium and bone metabolism ................................... 402
Chapter 45: drug therapy for addison's disease and cushing's disease ................................ 411
Section 9: drugs affecting the autonomic and central nervous system
............................................................................................................... 418
, Chapter 46: physiology of the autonomic and central nervous systems and indications for the
use of drug therapy ................................................................................................................. 418
Chapter 47: drug therapy for myasthenia gravis, alzheimer's disease, and urinary retention
................................................................................................................................................. 428
Chapter 48: drug therapy for parkinson's disease, urinary spasticity, and disorders requiring
anticholinergic drug therapy ................................................................................................... 438
Chapter 49: drug therapy with opioids .................................................................................. 448
Chapter 50: drug therapy with local anesthetics ................................................................... 457
Chapter 51: drug therapy with general anesthetics .............................................................. 464
Chapter 52: drug therapy for migraines and other headaches ............................................. 470
Chapter 53: drug therapy for seizure disorders and spasticity .............................................. 477
Chapter 54: drug therapy for anxiety and insomnia .............................................................. 486
Chapter 55: drug therapy for depression and mood stabilization ......................................... 496
Chapter 56: drug therapy for psychotic disorders ................................................................. 506
Chapter 57: drug therapy for attention deficit hyperactivity disorder and narcolepsy ......... 516
Chapter 58: drug therapy for substance abuse disorders ...................................................... 525
Section 10: drugs affecting the eye, ear, and skin .............................. 535
Chapter 59: drug therapy for disorders of the eye ................................................................ 535
Chapter 60: drug therapy for disorders of the ear................................................................. 544
Chapter 61: drug therapy for disorders of the skin ............................................................... 552
,Section 1: the conceptual framework of pharmacology
Chapter 1: the foundation of pharmacology: quality and safety
1. A woman has been prescribed paroxetine hydrochloride, which is an antidepressant
agent administered in pill form. The medication is administered for her obsessive- compulsive
disorder. This medication will produce which of the following effects?
A) curative
B) systemic
C) local
D) parenteral
Answer: b
Feedback: drugs that produce systemic effects are taken into the body, circulated through the
bloodstream to their sites of action in various body tissues, and eventually eliminated from the
body. Curative agents are given to cure a disease process. In this case, paroxetine hydrochloride
will control the symptoms but not cure the disorder. Drugs with local effects, such as sunscreen
and local anesthetics, act mainly at the site of application. Paroxetine hydrochloride is not
administered parenterally. Parenteral agents are administered subcutaneously, intramuscularly,
or intravenously.
2. A patient has been prescribed an antibiotic. This medication is a naturally occurring
substance that has been chemically modified. What is another name for this type of
medication?
A) synthetic drug
B) semisynthetic drug
C) biotechnology drug
D) prototype drug
Answer: b
Feedback: semisynthetic drugs (e.g., many antibiotics) are naturally occurring substances that
have been chemically modified. Synthetic drugs are more standardized in their chemical
, characteristics, more consistent in their effects, and less likely to produce allergic reactions.
Biotechnology drugs involve manipulating dna and rna and recombining genes into hybrid
molecules that can be inserted into living organisms. Prototype drugs are the first drug of a
particular group to be developed.
3. A patient is administered morphine. Morphine is a prototypical drug that can be
classified in different ways. Which of the following classifications applies to morphine?
A) central nervous system depressant
B) central nervous system stimulant
C) anti-inflammatory
D) antihypertensive
Answer: a
Feedback: drugs are classified according to their effects on particular body systems, their
therapeutic uses, and their chemical characteristics. For example, morphine can be classified as
a central nervous system depressant and a narcotic or opioid analgesic. A central nervous
system stimulant increases attention and raises mood. An anti-inflammatory agent decreases
inflammation at the site of tissue or joint inflammation. An antihypertensive agent reduces
blood pressure.
4. A patient is administered amoxicillin (amoxil). The generic name of this medication
indicates that it belongs to which drug group?
A) selective serotonin reuptake inhibitors
B) diuretics
C) penicillin’s
D) ace inhibitors
Answer: c
Feedback: the generic name often indicates the drug group (e.g., drugs with generic names
ending in “cillin” are penicillins). Selective serotonin reuptake inhibitors are medications that
have antidepressant effects; ssri is a broad classification, not a generic name. Diuretics are
