Page 0
WGU D115
COMPREHENSIVE STUDY GUIDE
64 QUESTIONS & ANSWERS
LATEST UPDATE 2026–27
Course Code: WGU D115
Pathophysiology • Genetics • Immunity
Respiratory • Cardiovascular • Renal
Endocrine • GI • Musculoskeletal
Hematology • Shock • Exam Review
WGU D115 Comprehensive Study Guide – 64 Questions &
Answers | Latest Update 2026/27
pg. 0
,A child with Down's syndrome has had frequent respiratory tract infections since
birth. What should the APRN tell the parent is the underlying cause of this illness?
- correct answers ✅Gastroesophageal reflux disease causes aspiration of thin
fluids.
Feedback: Gastroesophageal reflux is commonly seen in children with Down
syndrome and can be severe enough to result in aspiration of stomach contents,
causing respiratory symptoms such as persistent coughing, wheezing, and
pneumonia
The FNP understands that a female patient with a complete or partial absence of
the second sex chromosome may also display which of the following physical
signs? - correct answers ✅Ovarian failure
Feedback: Turner's syndrome occurs in approximately 1 in 2500 live births. It is
diagnosed by complete or partial absence of the second sex chromosome (45, X).
Patients may also demonstrate congenital lymphedema of hands and feet,
webbed neck, high-arched palate, and short fourth metacarpal. Short stature,
Ovarian failure, cardiovascular and renal issues, ear malformations, and other
health problems, as well as amenorrhea due to premature ovarian failure
An example of a disease that is caused by a chromosomal deletion is cri du chat
syndrome. Children affected with this disorder commonly display which of the
following symptoms? - correct answers ✅Symptoms associated with cri du chat
include low birth weight, severe intellectual disability, microcephaly, and heart
defects.
P a g e 1 | 19
, What type of immunity is the body's 3rd line of defense and includes the primary
characteristics of specificity and memory. - correct answers ✅Adaptive
Feedback: The third line of defense in the human body is adaptive (acquired)
immunity.
The local manifestations of inflammation result from vascular changes and the
circulation of associated components into the tissue. The 4 cardinal signs of
inflammation include all of the following: - correct answers ✅Swelling, pain,
heat, and redness are the cardinal signs of inflammation.
Patients with trisomy of the 21st chromosome are also predisposed to which of
the following diseases, which is also affected by alterations in the 21st
chromosome? - correct answers ✅Alzheimer Disease
Which assessment findings are typically associated with a diagnosis of systemic
lupus erythematous? - correct answers ✅Joint pain, malar rash, and
photosensitivity
Feedback: The symptoms most often experiences with SLE are arthritis,
arthralgias, fatigue, Reynaud phenomenon, chronic low-grade fever, sun
sensitivity, hair loss, weakness, malar facial rash, and weight loss.
P a g e 2 | 19
WGU D115
COMPREHENSIVE STUDY GUIDE
64 QUESTIONS & ANSWERS
LATEST UPDATE 2026–27
Course Code: WGU D115
Pathophysiology • Genetics • Immunity
Respiratory • Cardiovascular • Renal
Endocrine • GI • Musculoskeletal
Hematology • Shock • Exam Review
WGU D115 Comprehensive Study Guide – 64 Questions &
Answers | Latest Update 2026/27
pg. 0
,A child with Down's syndrome has had frequent respiratory tract infections since
birth. What should the APRN tell the parent is the underlying cause of this illness?
- correct answers ✅Gastroesophageal reflux disease causes aspiration of thin
fluids.
Feedback: Gastroesophageal reflux is commonly seen in children with Down
syndrome and can be severe enough to result in aspiration of stomach contents,
causing respiratory symptoms such as persistent coughing, wheezing, and
pneumonia
The FNP understands that a female patient with a complete or partial absence of
the second sex chromosome may also display which of the following physical
signs? - correct answers ✅Ovarian failure
Feedback: Turner's syndrome occurs in approximately 1 in 2500 live births. It is
diagnosed by complete or partial absence of the second sex chromosome (45, X).
Patients may also demonstrate congenital lymphedema of hands and feet,
webbed neck, high-arched palate, and short fourth metacarpal. Short stature,
Ovarian failure, cardiovascular and renal issues, ear malformations, and other
health problems, as well as amenorrhea due to premature ovarian failure
An example of a disease that is caused by a chromosomal deletion is cri du chat
syndrome. Children affected with this disorder commonly display which of the
following symptoms? - correct answers ✅Symptoms associated with cri du chat
include low birth weight, severe intellectual disability, microcephaly, and heart
defects.
P a g e 1 | 19
, What type of immunity is the body's 3rd line of defense and includes the primary
characteristics of specificity and memory. - correct answers ✅Adaptive
Feedback: The third line of defense in the human body is adaptive (acquired)
immunity.
The local manifestations of inflammation result from vascular changes and the
circulation of associated components into the tissue. The 4 cardinal signs of
inflammation include all of the following: - correct answers ✅Swelling, pain,
heat, and redness are the cardinal signs of inflammation.
Patients with trisomy of the 21st chromosome are also predisposed to which of
the following diseases, which is also affected by alterations in the 21st
chromosome? - correct answers ✅Alzheimer Disease
Which assessment findings are typically associated with a diagnosis of systemic
lupus erythematous? - correct answers ✅Joint pain, malar rash, and
photosensitivity
Feedback: The symptoms most often experiences with SLE are arthritis,
arthralgias, fatigue, Reynaud phenomenon, chronic low-grade fever, sun
sensitivity, hair loss, weakness, malar facial rash, and weight loss.
P a g e 2 | 19
