ABGC BOARD TEST |ACTUAL QUESTIONS AND
VERIFIED ANSWERS|BRAND NEW 2026-2027
UPDATE|GRADED A+
Question 1
A 45-year-old patient with colon cancer comes for genetic counseling. In conjunction with
microsatellite instability testing, which of the following is the BEST next step in deciding if
the tumor is the result of Lynch syndrome?
a. BRAF mutation testing
b. immunohistochemical testing
c. methylation testing
d. KRAS mutation testing
CORRECT ANSWER
Immunohistochemical testing
Question 2
Which of the following issues is MOST important to discuss with a parent regarding testing
their minor child for a familial MSH2 pathogenic variant?
a. justice
b. beneficence
c. nonmaleficence
d. autonomy
CORRECT ANSWER
Autonomy
Question 3
1
@THE STUDY VAULT
, Before disclosing test results to an adult patient by phone, a genetic counselor should
FIRST?
a. determine if a support person is present
b. confirm the genetic counselor is speaking to the patient
c. re-assess understanding of possible test results
d. re-establish rapport by making small talk
CORRECT ANSWER
Confirm the genetic counselor is speaking to the patient
Question 4
A couple seeks counseling because their first child was born with a ventricular septal
defect. There is no family history of any congenital heart disease, and the parents have
normal cardiac examinations. They should be counseled that the risk that a subsequent
child will have a similar or other cardiac defect is closest to?
a. 8-10%
b. 25%
c. less than 1%
d. 3-5%
CORRECT ANSWER
3-5%
Question 5
Exome sequencing is performed for a child with microcephaly, atrial septal defect,
intellectual disability, and gross motor delay. A pathogenic variant is identified in a gene
associated with Brugada syndrome. The BEST interpretation of this finding is that it is?
a. a medically actionable secondary finding
b. a partial explanation of the patient's phenotype
2
@THE STUDY VAULT
VERIFIED ANSWERS|BRAND NEW 2026-2027
UPDATE|GRADED A+
Question 1
A 45-year-old patient with colon cancer comes for genetic counseling. In conjunction with
microsatellite instability testing, which of the following is the BEST next step in deciding if
the tumor is the result of Lynch syndrome?
a. BRAF mutation testing
b. immunohistochemical testing
c. methylation testing
d. KRAS mutation testing
CORRECT ANSWER
Immunohistochemical testing
Question 2
Which of the following issues is MOST important to discuss with a parent regarding testing
their minor child for a familial MSH2 pathogenic variant?
a. justice
b. beneficence
c. nonmaleficence
d. autonomy
CORRECT ANSWER
Autonomy
Question 3
1
@THE STUDY VAULT
, Before disclosing test results to an adult patient by phone, a genetic counselor should
FIRST?
a. determine if a support person is present
b. confirm the genetic counselor is speaking to the patient
c. re-assess understanding of possible test results
d. re-establish rapport by making small talk
CORRECT ANSWER
Confirm the genetic counselor is speaking to the patient
Question 4
A couple seeks counseling because their first child was born with a ventricular septal
defect. There is no family history of any congenital heart disease, and the parents have
normal cardiac examinations. They should be counseled that the risk that a subsequent
child will have a similar or other cardiac defect is closest to?
a. 8-10%
b. 25%
c. less than 1%
d. 3-5%
CORRECT ANSWER
3-5%
Question 5
Exome sequencing is performed for a child with microcephaly, atrial septal defect,
intellectual disability, and gross motor delay. A pathogenic variant is identified in a gene
associated with Brugada syndrome. The BEST interpretation of this finding is that it is?
a. a medically actionable secondary finding
b. a partial explanation of the patient's phenotype
2
@THE STUDY VAULT
