Comprehensive Resource To Help You Ace 2026-2027 Exams
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1. Osteoporosis - Correct Answer: most common bone disease in humans
and is marked by low bone mineral density, impaired structural integrity,
and decreased bone strength. Increased risk of fractures. Primary
osteoporosis is idiopathic in nature and 2nd is caused by another condition.
2nd conditions include hormone imbalances, DM, hyperparathyroidism,
hyperthyroidism, heparin, corticosteroids, phenytoin, barbiturate, lithium,
tobacco, ethanol, HIV, rheumatoid disease, CKD, liver disease, and
malabsorption syndromes. Old bone breaks down faster than it is being
made and the bone become porous and thin. Commonly diagnosed after
someone has sustained a fracture.
2. Osteoporosis - Correct Answer: most common bone disease in humans
and is marked by low bone mineral density, impaired structural integrity,
and decreased bone strength. Increased risk of fractures. Primary
osteoporosis is idiopathic in nature and 2nd is caused by another condition.
2nd conditions include hormone imbalances, DM, hyperparathyroidism,
hyperthyroidism, heparin, corticosteroids, phenytoin, barbiturate, lithium,
tobacco, ethanol, HIV, rheumatoid disease, CKD, liver disease, and
malabsorption syndromes. Old bone breaks down faster than it is being
made and the bone become porous and thin. Commonly diagnosed after
someone has sustained a fracture.
,3. Osteoporosis patho - Correct Answer: Bone homeostasis is dependent
upon the balance between the cytokine receptor activator of nuclear factor
κβ ligand (RANKL), its receptor RANK and its decoy receptor
osteoprotegerin (OPG). Osteoblasts express RANKL which is necessary for
osteoclast development. RANKL activates the RANK receptor which is
expressed on osteoclasts. This prolongs the life of the osteoclasts. The
effects of RANKL are mitigated by OPG, which acts as a decoy receptor for
RANKL and prevents it from binding to RANK. This process is regulated by
cytokines and hormones. An alteration in this system leads to osteoporosis,
immune mediated bone diseases, malignant bone disorders and inherited
skeletal diseases.
4. Osteoporosis patho - Correct Answer: Bone homeostasis is dependent
upon the balance between the cytokine receptor activator of nuclear factor
κβ ligand (RANKL), its receptor RANK and its decoy receptor
osteoprotegerin (OPG). Osteoblasts express RANKL which is necessary for
osteoclast development. RANKL activates the RANK receptor which is
expressed on osteoclasts. This prolongs the life of the osteoclasts. The
effects of RANKL are mitigated by OPG, which acts as a decoy receptor for
RANKL and prevents it from binding to RANK. This process is regulated by
cytokines and hormones. An alteration in this system leads to osteoporosis,
immune mediated bone diseases, malignant bone disorders and inherited
skeletal diseases.
5. Bone density classifications - Correct Answer: normal bone mass>833.
Osteopenia: 648-833. Osteoporosis<648
6. Bone density classifications - Correct Answer: normal bone mass>833.
Osteopenia: 648-833. Osteoporosis<648
, 7. Osteoarthritis (OA) - Correct Answer: joint disease that results in the
loss of articular cartilage and destruction of the joint capsule. May occur
2nd to aging or as a result of long term mechanical stress caused by sports,
obesity or chronic diseases. Patho is the degeneration of the articulating
cartilage. This leads to increased remodeling of the cartilage and loss of
smooth frictionless joint. This is progressive which will eventually require
joint replacement surgery
8. Osteoarthritis (OA) - Correct Answer: joint disease that results in the
loss of articular cartilage and destruction of the joint capsule. May occur
2nd to aging or as a result of long term mechanical stress caused by sports,
obesity or chronic diseases. Patho is the degeneration of the articulating
cartilage. This leads to increased remodeling of the cartilage and loss of
smooth frictionless joint. This is progressive which will eventually require
joint replacement surgery
9. OA S&S - Correct Answer: Dependent on the affected joint. Pain and
stiffness are the predominant symptoms. Joint swelling, tenderness and
deformity are common. Symptoms are worsened with weight bearing or
joint use and relieved with rest
10.OA S&S - Correct Answer: Dependent on the affected joint. Pain and
stiffness are the predominant symptoms. Joint swelling, tenderness and
deformity are common. Symptoms are worsened with weight bearing or
joint use and relieved with rest