NURS 3517 - Pharmacology - Test 1
Absorption - ANS-- Movement of a drug from the site of administration into the bloodstream
- Bioavailability: volume of drug absorption or "portion of dose that reaches systemic
move....Available to act on frame cells"
- First Pass Effect
Absorption of Parenterals - ANS-- pH need to be just like blood
Not too concentrated/corrosive
IV on the spot & entire a hundred%
- IM speedy to long-appearing
- Subcut just like IM
Absorption: First-Pass Effect - ANS-- Medications absorbed thru digestive device are
transported to the liver thru the hepatic-portal vein
- The liver inactivates a part of the medicine before freeing it returned into systemic circulate
- This ↓ bioavailability of the medication
- ↑ FPE=drug calculated to compensate*
Additional Considerations - ANS-- Drug interactions
- Additive results
- Synergistic effects
- Antagonistic effects
- Incompatibility
- Adverse drug occasion
- Medication errors
- Adverse drug withdrawal event
- Adverse drug response
- Allergic reaction
- Idiosyncratic response
- Other drug consequences
,Adverse Drug Event - ANS-General time period: Encompasses all types of medical problems on
account of medicinal drug use
Adverse drug reactions (ADRs):
- Allergic reaction
- Idiosyncratic response
Medication mistakes
Agonist - ANS-Drugs that bind to and stimulate the hobby of 1 or greater receptors inside the
frame
Albumin: Primary Protein - ANS-3 situations that purpose ↓ albumin levels
- burns
- malnourishment
- (−) N balance
Altering Rate of Metabolism - ANS-Delaying drug metabolism results in:
- Accumulation of medicine
- Prolonged action of the drugs
Stimulating drug metabolism reasons:
- Diminished therapeutic outcomes
Antagonist - ANS-Drugs that bind to and inhibit activity of 1 more greater receptors within the
frame
Areas of Potential Liability - ANS-- Liable for negligence and malpractice Failure to evaluate or
re-evaluate
- Failure to make sure safety
- Medication mistakes
Authorizing Mechanisms - ANS-- Order
- Directive
Having the authority to manage a medicine does not necessarily imply it's miles appropriate to
achieve this!
Canadian Food and Drug Act - ANS-- Primary piece of legislation governing meals, drugs,
cosmetics, and medical gadgets
- According to the Act, pills must observe reputable prescribed requirements
- Recognized formularies
,- Various schedules
- Health Products and FoodBranch federal regulator
Changes Across the Lifespan - ANS-Age associated changes have a dramatic impact on
pharmacokinetics
Increased danger of detrimental effects and toxicity at each ends of spectrum of life
Considerations for Older Adult Patients - ANS-- Older adults: older than age sixty five years
- High use of medicines
- Polypharmacy
- Nonadherence
- Increased occurrence of persistent illnesses
- Sensory and motor deficits
ADME
A - Absorption
D - Distribution
M - Metabolism
E - Excretion
Controlled Acts - ANS-- Acts considered harmful if executed through unqualified humans.
- five of 14 legal to nursing when ordered
Controlled Acts for Nursing - ANS-1) Perform a prescribed system under the dermis/mucous
membrane.
2) Administer a substance by injection or inhalation
3) Put an device, hand or finger past a body orifice or artificial establishing in the frame.
Four) Dispensing a drug. (NEW for RPNs)
5) Treating by Psychotherapy
Controlled Drugs and Substances Act (CDSA) - ANS-- Replaced the Narcotic Control Act in
1997.
- Provides necessities for the manipulate and sale of narcotics, controlled pills, and materials of
misuse
- The letter N and the image C are printed on the label of each narcotic drug.
, - RCMP is liable for enforcement of the CDSA
Directive - ANS-Written, pre-current orders, a collection of customers
Dissolution of Oral Medications - ANS-Solid medicines must be dissolved in fluid so as for
absorption to arise
- Additives/Coatings
- Enteric-Coated
- Time-Released
Distribution - ANS-Transport of a drug through the bloodstream to the drug's website of
movement
Drugs distributed first to regions with significant blood deliver
◦Heart, liver, kidneys and mind
Drug - ANS-Any chemical that affects the physiological tactics of a living organism
Drug Classification - ANS-- Drugs are grouped together based totally on their similar homes
- Drugs may be categorised through their structure
- Drugs can be classified with the aid of their therapeutic use
Drug Names: Chemical Name - ANS-Describes the drug's chemical composition and molecular
structure
Example: IBUPROFEN
(+/-)-2-(p-isobutylphenyl) propionic acid
Drug Names: Generic Name (nonproprietary, professional call) - ANS-Name given to a drug
accepted through Health Canada
Example: IBUPROFEN
Drug Names: Trade Name (propriety name, ®) - ANS-The drug has a registered trademark; use
of the name is restricted via the drug's patent proprietor (typically the manufacturer).
Example: IBUPROFEN
Advil, Motrin, Etc
Drug Standards (5 Total) - ANS-- Purity
Absorption - ANS-- Movement of a drug from the site of administration into the bloodstream
- Bioavailability: volume of drug absorption or "portion of dose that reaches systemic
move....Available to act on frame cells"
- First Pass Effect
Absorption of Parenterals - ANS-- pH need to be just like blood
Not too concentrated/corrosive
IV on the spot & entire a hundred%
- IM speedy to long-appearing
- Subcut just like IM
Absorption: First-Pass Effect - ANS-- Medications absorbed thru digestive device are
transported to the liver thru the hepatic-portal vein
- The liver inactivates a part of the medicine before freeing it returned into systemic circulate
- This ↓ bioavailability of the medication
- ↑ FPE=drug calculated to compensate*
Additional Considerations - ANS-- Drug interactions
- Additive results
- Synergistic effects
- Antagonistic effects
- Incompatibility
- Adverse drug occasion
- Medication errors
- Adverse drug withdrawal event
- Adverse drug response
- Allergic reaction
- Idiosyncratic response
- Other drug consequences
,Adverse Drug Event - ANS-General time period: Encompasses all types of medical problems on
account of medicinal drug use
Adverse drug reactions (ADRs):
- Allergic reaction
- Idiosyncratic response
Medication mistakes
Agonist - ANS-Drugs that bind to and stimulate the hobby of 1 or greater receptors inside the
frame
Albumin: Primary Protein - ANS-3 situations that purpose ↓ albumin levels
- burns
- malnourishment
- (−) N balance
Altering Rate of Metabolism - ANS-Delaying drug metabolism results in:
- Accumulation of medicine
- Prolonged action of the drugs
Stimulating drug metabolism reasons:
- Diminished therapeutic outcomes
Antagonist - ANS-Drugs that bind to and inhibit activity of 1 more greater receptors within the
frame
Areas of Potential Liability - ANS-- Liable for negligence and malpractice Failure to evaluate or
re-evaluate
- Failure to make sure safety
- Medication mistakes
Authorizing Mechanisms - ANS-- Order
- Directive
Having the authority to manage a medicine does not necessarily imply it's miles appropriate to
achieve this!
Canadian Food and Drug Act - ANS-- Primary piece of legislation governing meals, drugs,
cosmetics, and medical gadgets
- According to the Act, pills must observe reputable prescribed requirements
- Recognized formularies
,- Various schedules
- Health Products and FoodBranch federal regulator
Changes Across the Lifespan - ANS-Age associated changes have a dramatic impact on
pharmacokinetics
Increased danger of detrimental effects and toxicity at each ends of spectrum of life
Considerations for Older Adult Patients - ANS-- Older adults: older than age sixty five years
- High use of medicines
- Polypharmacy
- Nonadherence
- Increased occurrence of persistent illnesses
- Sensory and motor deficits
ADME
A - Absorption
D - Distribution
M - Metabolism
E - Excretion
Controlled Acts - ANS-- Acts considered harmful if executed through unqualified humans.
- five of 14 legal to nursing when ordered
Controlled Acts for Nursing - ANS-1) Perform a prescribed system under the dermis/mucous
membrane.
2) Administer a substance by injection or inhalation
3) Put an device, hand or finger past a body orifice or artificial establishing in the frame.
Four) Dispensing a drug. (NEW for RPNs)
5) Treating by Psychotherapy
Controlled Drugs and Substances Act (CDSA) - ANS-- Replaced the Narcotic Control Act in
1997.
- Provides necessities for the manipulate and sale of narcotics, controlled pills, and materials of
misuse
- The letter N and the image C are printed on the label of each narcotic drug.
, - RCMP is liable for enforcement of the CDSA
Directive - ANS-Written, pre-current orders, a collection of customers
Dissolution of Oral Medications - ANS-Solid medicines must be dissolved in fluid so as for
absorption to arise
- Additives/Coatings
- Enteric-Coated
- Time-Released
Distribution - ANS-Transport of a drug through the bloodstream to the drug's website of
movement
Drugs distributed first to regions with significant blood deliver
◦Heart, liver, kidneys and mind
Drug - ANS-Any chemical that affects the physiological tactics of a living organism
Drug Classification - ANS-- Drugs are grouped together based totally on their similar homes
- Drugs may be categorised through their structure
- Drugs can be classified with the aid of their therapeutic use
Drug Names: Chemical Name - ANS-Describes the drug's chemical composition and molecular
structure
Example: IBUPROFEN
(+/-)-2-(p-isobutylphenyl) propionic acid
Drug Names: Generic Name (nonproprietary, professional call) - ANS-Name given to a drug
accepted through Health Canada
Example: IBUPROFEN
Drug Names: Trade Name (propriety name, ®) - ANS-The drug has a registered trademark; use
of the name is restricted via the drug's patent proprietor (typically the manufacturer).
Example: IBUPROFEN
Advil, Motrin, Etc
Drug Standards (5 Total) - ANS-- Purity
