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SBB ASCP Final Practice Test 2026–2027 | Specialist in Blood Banking Exam Questions & Verified Answers | Complete Certification Prep

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Prepare for the SBB ASCP Specialist in Blood Banking Exam 2026–2027 with this comprehensive practice test resource featuring exam-style questions and verified answers for focused certification preparation. The material supports advanced review across immunohematology, ABO and Rh blood group systems, red cell antigens, antibody screening and identification, compatibility testing, complex serologic investigations, blood components, transfusion reactions, donor and recipient testing, hemolytic disease of the fetus and newborn, transfusion medicine, quality management, laboratory operations, and blood banking procedures. Ideal for candidates searching for an SBB ASCP practice test, Specialist in Blood Banking exam questions, ASCP BOC SBB exam prep, immunohematology practice questions, or transfusion medicine certification review, this resource provides a structured way to reinforce high-yield concepts, practice applying advanced blood banking knowledge, identify weak areas, and strengthen readiness for the 2026–2027 certification examination.

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SBB ASCP Practice Test
b. Reduce the flow rate. A donor experiences perioral paresthesia during an apheresis procedure. Which
of the following should be performed?
a. Increase the flow rate.
b. Reduce the flow rate.
c. Elevate the donor's feet.
d. Have the donor breathe into a paper bag.


c. Obtain a written request from the patient's physician A unit of autologous blood tested repeatedly reactive for HBsAg. The patient is
and send the unit with a biohazard label and "autologous scheduled for surgery in three days. What action should be taken?
use only." a. Discard the unit.
b. Send the unit with a biohazard label and "autologous use only."
c. Obtain a written request from the patient's physician and send the unit with a
biohazard label and
"autologous use only."
d. Wait for confirmatory testing before contacting physician to see what he wants
to do.


a. Male, age 72, Hb 13.5, BP 124/88 Which of the following individuals can be accepted for allogeneic blood donation?
a. Male, age 72, Hb 13.5, BP 124/88
b. Female, age 22, Hb 14.0, spontaneous abortion 5 weeks ago
C. Female, age 37, Hb 12.2, BP 160/116
d. Male, age 61, Hb 12, cardiac bypass surgery 4 years ago
e. Female, age 61, Hb 13.5, breast cancer 5 years ago


a. Accept the donor. A 64-year-old male prospective donor states that he had a positive TB skin test
one year ago. When further questioned, he states that the x-ray was done and
was negative with no other abnormal
findings. You should:
a. Accept the donor.
b. Defer the donor for 6 months.
c. Defer the donor for 1 year.
d. Defer the donor indefinitely.


b. Have the donor breathe into a paper bag. A 27-year old truck driver has just finished donating blood and complained of
tingling in his fingers and toes, and his fingers are in a strange rigid position.
What should be done?
a. Give the donor a beverage and cookies.
b. Have the donor breathe into a paper bag.
c. Ask the donor to lie down and elevate his feet.
d. Administer oxygen immediately.


b. 1 hour When preparing cryoprecipitate from plasma, the cryoprecipitate must be placed
in the freezer within
___ after removal from the refrigerated centrifuge.
a. 15 minutes
b. 1 hour
c. 6 hours
d. 24 hours


b. Thawed plasma FFP thawed but not used can be relabeled to:
a. Liquid plasma
b. Thawed plasma
c. Recovered plasma
d. Source plasma


c. EIA initial testing reactive, and one of the duplicate Donated blood may NOT be used for allogeneic transfusion when HCV testing
repeat results is reactive shows:
a. EIA initial testing reactive
b. EIA initial testing reactive and RNA testing nonreactive
c. EIA initial testing reactive, and one of the duplicate repeat results is reactive
d. EIA initial tesling is reactive, and both of the duplicate repeat results are
nonreactive


b. 9 With nucleic acid testing, the window period of HIV is approximately how many
days?
a. 5
b. 9
C. 16
d. 22

, SBB ASCP Practice Test
c. Infection is clear The following hepatitis B testing results indicates:
HBsAG=Non-reactive, Anti-HBc=Reactive, Anti-HBs=Reactive, HBV DNA=Non-
reactive
a. Acute infection
b. Chronic infection
c. Infection is clear
d. Recurring infection
e. The person has received hepatitis B vaccination




b. Chronic infection The following hepatitis C testing results indicates:
HCV RNA=Reactive, Anti-HCV (IgM)=Nonreactive,
Anti-HCV (lgG)=Reactive
a. Acute infection
b. Chronic infection
c. Infection resolved
d. Recurring infection




b. Autosomal recessive inheritance A family study consists of 4 daughters, 4 sons, and 12 grandchildren. One son
and one daughter have an inherited genetic disorder that is not present in any of
the grandchildren. This is an example of:
a. Sex-linked dominant inheritance
b. Autosomal recessive inheritance
c. Autosomal dominant inheritance
d. Non-paternity


c. Crossing over A disease is linked to the ABO system. The pedigree demonstrates:
a. Parental haplotye
b. Linkage disequilibrium
c. Crossing over
d. Nondisjunction




c. Fathers to 100% of sons and no daughters A trait carried on the Y chromosome will be passed from:
a. Fathers to 50% of sons or daughters
b. fathers to 100% of sons and 50% of daughters
c. Fathers to 100% of sons and no daughters
d. Fathers to 100% of daughters and no sons


C. 50% A man who is genotype AO married a genotype 00 woman. What is the
probability that their first child will be type A?
a. 12.5%
b. 25%
C. 50%
d. 75%


b. Cer-Glu-Gal-GlcNac-Gal-Fuc Which of the following represent the biochemical structure of the H antigen on
red cells?
a. Cer-Glu-Gal-GlcNac-GalNac
b. Cer-Glu-Gal-GlcNac-Gal-Fuc
c. Cer-Glu-Gal-GlcNac-Glu-Fuc
d. Cer-Glu-Gal-GlcNac-Gal-Glu


c. A2O, HH, Lele, sese A man phenotypes A2, Le(a+b-). His saliva shows only Lea. Which of the
following best represents his genotype?
a. A2O, HH, Lele, Sese
b. A2A2, Hh, lele, sese
c. A2O, HH, Lele, sese
d. A2O, Hh, lele, Sese

, SBB ASCP Practice Test
d. r'r" The following Rh phenotyping results are obtained. What is the most likely
genotype?
D=0, C=+, E=+, c=+, e=+, f=0
a. rr
b. r'r
c. r''r
d. r'r"




d. R0r' An Rh-negative woman has requested prediction of the Rh genotype of her
offspring. Phenotyping results of her family shows the following results. What is
the husband's most likely Rh genotype?
Woman=dce, Her husband=DCce, Husband's mother= dCce, Husband's
brother=Dce
a. R1 r'
b. r'r'
c. R1 r
d. R0r'




b. Ser-Ser-Thr-Thr-Gly The amino acid sequence responsible for the M antigen is:
a. Leu-Ser-Thr-Thr-Glu
b. Ser-Ser-Thr-Thr-Gly
c. Leu-Ser-Ser-Thr-Glu
d. Thr-Ser-Thr-Leu-Gly


d. Jsa The antigen that occurs in approximately 20% of individuals of African ethnicity
is:
a. K
b. Kpa
C. Kpb
d. Jsa


c. JkbJk Refer to the family study. The propositus' genotype is most likely:
a. JkaJkb
b. JkaJka
c. JkbJk
d. Jk3Jk3
e. JkbJkb




a. Vel Finding compatible RBCs would be most difficult for patients with antibody to:
a. Vel
b. D, C, E, K
c. C, Fya
d. Wra, Hta


c. Dia is more frequent in individuals of Mongolian The Diego blood group is of anthropological interest because:
ancestry. a. Dia is a common antigen in the Caucasian population.
b. ma is found in few African Americans.
c. Dia is more frequent in individuals of Mongolian ancestry.
d. Di(a-b-) individuals are usually Hispanic.


b. CH/RG:1,2,3, 11, 12 The most common CH/RG phenotype is:
a. CH/RG:1,2,-3, 11,-12
b. CH/RG:1,2,3, 11, 12
c. CH/RG:1,-2,3,11,12
d. CH/RG:1,2,-3,11,12

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