CDCES Exam - Diabetes Medications
Afrezza - ANS-- Insulin/Action: inhaled ordinary human insulin / Bolus
- Dose Range: 4, eight, and 12 unit cartridges before food
- Onset: 12 minutes
- Peak: 35-45 minutes
- Duration: 1.Five-3 hours
- Considerations: Assess lung fxn, keep away from lung sickness
- Side results: hypoglycemia, cough, throat infection
Aspart (Fiasp) - ANS-- Very rapid performing analog
- Onset: 16-20 minutes
- Peak: 1-three hours
- Duration: 5-7 hours
Aspart (Novolog) - ANS-- Rapid acting analog
- Onset: 20-half-hour
- Peak: 1-three hours
- Duration: 3-7 hours
Biguanides - ANS-- Decreases hepatic glucose output
- First line med at prognosis of type 2
Considerations for Biguanides - ANS-- Side Effects: nausea, bloating, diarrhea, B12-deficiency.
To limit GI aspect consequences, use XR and take w/ meals
- Obtain GFR before starting: If GFR <30 do no longer use, If GFR <45, don't start, if pt is on
remedy, and GFR falls to 30-45, eval danger vs advantage and do not forget decreasing dose
- For dye examine: if GFR <60, liver sickness, alcoholism, or coronary heart failure, restart
metformin after 48 hours if renal feature stable
- Benefits: lowers cholesterol, no hypo or weight advantage, cheap, accredited for pediatrics,
10+ yrs
- Lowers A1c by means of 1.0-2.Zero%
Considerations for Sulfonylureas - ANS-- Can take a few times each day earlier than meals
- Low fee commonplace
- Side effects: hypoglycemia and weight benefit, removed via kidney
- Caution: glyburide maximum likely to motive hypoglycemia
- Lowers A1c: 1.0 - 2.Zero %
Considerations of GLP-1 - ANS-- Side Effects: Nausea, vomiting, weight loss, injection website
online reaction, acute pancreatitis or intestinal blockage.
, - Increase dose monthly to attain target
- Black field warning: Thyroid C-cell tumor caution (keep away from if family history of medullary
thyroid tumor).
- Significantly reduces risk of CV loss of life, heart attack, and stroke
- Approved for peds 10-17 yrs
- Lower A1c with the aid of 0.5 - 1.6%
- Expected weight reduction: four-6%
Degludec (Tresiba) - ANS-- Long acting
- Onset: ~1 hour
- Peak: no height
- Duration: <42 hours
Dulaglutide (Trulicity) - ANS-- Class/Main Action: GLP-1 RA
- Dose Range: 0.75, 1.5, 3.0, and 4.5 mg 1x/wk pen injector
Exenatide (Byetta) - ANS-- Class/Main Action: GLP-1 RA (Incretin Mimetic)
- Dose Range: 5 and 10 mcg BID
Exenatide XR (Bydureon) - ANS-- Class/Main Action: GLP-1 RA
- Dose Range: 2 mg 1x/wk
Extended Release - XR (Glucophage XR, Flumetza, Fortamet) - ANS-- Class: Biguanides
- Daily Dose Range: 500 - 2000 mg, 500 - 2000 mg, 500 - 2500 mg
Glargine (Lantus/Basaglar/Semglee/Rezvoglar) - ANS-- Long acting
- Onset: 2-4 hours
- Peak: no peak
- Duration: 20-24 hours
Glimepiride (Amaryl) - ANS-- Class: Sulfonylurea
- Daily Dose Range: 1.0 - 8 mg
Glipizide (Glucotrol, Glucotrol XL) - ANS-- Class: Sulfonylurea
- Daily Dose Range: 2.5 - 40 mg, 2.5 - 20 mg)
Glulisine (Apidra) - ANS-- Rapid acting analog
- Onset: 15-30 minutes
- Peak: 1-3 hours
- Duration: 3-4 hours
Glyburide (Diabeta) - ANS-- Class: Sulfonylurea
- Daily Dose Range: 1.25 - 20 mg
Afrezza - ANS-- Insulin/Action: inhaled ordinary human insulin / Bolus
- Dose Range: 4, eight, and 12 unit cartridges before food
- Onset: 12 minutes
- Peak: 35-45 minutes
- Duration: 1.Five-3 hours
- Considerations: Assess lung fxn, keep away from lung sickness
- Side results: hypoglycemia, cough, throat infection
Aspart (Fiasp) - ANS-- Very rapid performing analog
- Onset: 16-20 minutes
- Peak: 1-three hours
- Duration: 5-7 hours
Aspart (Novolog) - ANS-- Rapid acting analog
- Onset: 20-half-hour
- Peak: 1-three hours
- Duration: 3-7 hours
Biguanides - ANS-- Decreases hepatic glucose output
- First line med at prognosis of type 2
Considerations for Biguanides - ANS-- Side Effects: nausea, bloating, diarrhea, B12-deficiency.
To limit GI aspect consequences, use XR and take w/ meals
- Obtain GFR before starting: If GFR <30 do no longer use, If GFR <45, don't start, if pt is on
remedy, and GFR falls to 30-45, eval danger vs advantage and do not forget decreasing dose
- For dye examine: if GFR <60, liver sickness, alcoholism, or coronary heart failure, restart
metformin after 48 hours if renal feature stable
- Benefits: lowers cholesterol, no hypo or weight advantage, cheap, accredited for pediatrics,
10+ yrs
- Lowers A1c by means of 1.0-2.Zero%
Considerations for Sulfonylureas - ANS-- Can take a few times each day earlier than meals
- Low fee commonplace
- Side effects: hypoglycemia and weight benefit, removed via kidney
- Caution: glyburide maximum likely to motive hypoglycemia
- Lowers A1c: 1.0 - 2.Zero %
Considerations of GLP-1 - ANS-- Side Effects: Nausea, vomiting, weight loss, injection website
online reaction, acute pancreatitis or intestinal blockage.
, - Increase dose monthly to attain target
- Black field warning: Thyroid C-cell tumor caution (keep away from if family history of medullary
thyroid tumor).
- Significantly reduces risk of CV loss of life, heart attack, and stroke
- Approved for peds 10-17 yrs
- Lower A1c with the aid of 0.5 - 1.6%
- Expected weight reduction: four-6%
Degludec (Tresiba) - ANS-- Long acting
- Onset: ~1 hour
- Peak: no height
- Duration: <42 hours
Dulaglutide (Trulicity) - ANS-- Class/Main Action: GLP-1 RA
- Dose Range: 0.75, 1.5, 3.0, and 4.5 mg 1x/wk pen injector
Exenatide (Byetta) - ANS-- Class/Main Action: GLP-1 RA (Incretin Mimetic)
- Dose Range: 5 and 10 mcg BID
Exenatide XR (Bydureon) - ANS-- Class/Main Action: GLP-1 RA
- Dose Range: 2 mg 1x/wk
Extended Release - XR (Glucophage XR, Flumetza, Fortamet) - ANS-- Class: Biguanides
- Daily Dose Range: 500 - 2000 mg, 500 - 2000 mg, 500 - 2500 mg
Glargine (Lantus/Basaglar/Semglee/Rezvoglar) - ANS-- Long acting
- Onset: 2-4 hours
- Peak: no peak
- Duration: 20-24 hours
Glimepiride (Amaryl) - ANS-- Class: Sulfonylurea
- Daily Dose Range: 1.0 - 8 mg
Glipizide (Glucotrol, Glucotrol XL) - ANS-- Class: Sulfonylurea
- Daily Dose Range: 2.5 - 40 mg, 2.5 - 20 mg)
Glulisine (Apidra) - ANS-- Rapid acting analog
- Onset: 15-30 minutes
- Peak: 1-3 hours
- Duration: 3-4 hours
Glyburide (Diabeta) - ANS-- Class: Sulfonylurea
- Daily Dose Range: 1.25 - 20 mg
