HESI / Elsevier | HESI Milestone 2 Comprehensive Examination
HESI Milestone 2 Comprehensive
Examination 2026/2027 | Verified Questions
HESI / Elsevier | HESI Milestone 2 Comprehensive Examination | University-Level Nursing Students
100 Verified Questions | 4 Core Domains | Academic Year 2026/2027
Prepared by
HESI / Elsevier | HESI Milestone 2 Comprehensive Examination
Milestone 2 Comprehensive Examination Actual Exam | Academic Year 2026/2027
HESI Milestone 2 Comprehensive Examination 2026/2027 | Verified Questions
,INTRODUCTION
This Milestone 2 Comprehensive Examination contains 100 verified questions designed for university-
level nursing students preparing for the HESI Milestone 2 examination. The questions are distributed
equally across four core domains: Fundamentals of Nursing and Patient Safety (25 questions), Medical-
Surgical Nursing: Cardiovascular and Respiratory (25 questions), Medical-Surgical Nursing:
Gastrointestinal and Endocrine (25 questions), and Pharmacology and Medication Administration (25
questions). All content is original and constructed to reinforce the official HESI Milestone 2 course
objectives for actual exam readiness and clinical proficiency, aligned to the 2026/2027 academic year.
Each item emphasizes safe nursing care, pathophysiologic reasoning, and medication safety drawn from
foundational medical-surgical nursing methodology.
ACTUAL QUESTIONS
Domain 1: Fundamentals of Nursing and Patient Safety
Question 1. Which action is the single most effective method to prevent transmission of
infection in the healthcare setting?
A. Wearing sterile gloves for every client contact
B. Using a gown for all interactions
C. Performing hand hygiene before and after client contact and after touching potentially
contaminated surfaces
D. Administering prophylactic antibiotics to every client
Correct Answer: C
Rationale: Hand hygiene remains the cornerstone of infection prevention. Proper performance before
and after contact interrupts the chain of transmission more effectively than any other single measure.
Question 2. When is soap-and-water handwashing required instead of an alcohol-based
hand rub?
A. When hands are visibly soiled or after contact with Clostridium difficile or norovirus
B. Before entering any client room
C. After removing clean gloves only
D. Before preparing oral medications
Correct Answer: A
Rationale: Alcohol-based rubs are ineffective against spore-forming organisms such as C. difficile and
against norovirus when hands are heavily soiled. Visible soil or known exposure requires soap-and-
water washing.
Question 3. Which sequence is correct when removing contaminated personal protective
equipment?
A. Mask, goggles, gown, gloves
B. Gown first, then gloves
C. All items removed simultaneously
D. Gloves first, then gown, then eye protection, then mask or respirator
Correct Answer: D
Rationale: Removal begins with the most contaminated item (gloves), followed by gown, eye protection,
and finally the mask or respirator, minimizing self-contamination.
Question 4. A client is placed on contact precautions. Which PPE is required upon room
entry?
A. N95 respirator only
HESI Milestone 2 Comprehensive Examination 2026/2027 | Verified Questions
, B. Gown and gloves
C. Surgical mask and eye protection only
D. No PPE if contact is brief
Correct Answer: B
Rationale: Contact precautions require gown and gloves for all interactions that may involve contact
with the client or the client’s environment.
Question 5. Which statement correctly describes standard precautions?
A. They are used for all clients to protect against blood and body-fluid exposure regardless of
diagnosis
B. They apply only to clients with known infections
C. They replace the need for hand hygiene
D. They are required only during sterile procedures
Correct Answer: A
Rationale: Standard precautions treat all blood, body fluids, secretions, excretions (except sweat), non-
intact skin, and mucous membranes as potentially infectious and apply to every client.
Question 6. When preparing a sterile field, which action contaminates the field?
A. Opening the sterile package away from the body first
B. Keeping sterile gloved hands above the waist
C. Turning the back to the sterile field or allowing a non-sterile item to cross above it
D. Pouring sterile solution from a height of 4–6 inches
Correct Answer: C
Rationale: A sterile field is contaminated if it leaves the nurse’s line of sight or if a non-sterile object
passes over it. Continuous visual control is essential.
Question 7. Which needle-safety feature reduces the risk of needlestick injury after
injection?
A. A larger-gauge needle
B. A retractable or hinged needle shield that covers the needle after use
C. A reusable syringe barrel
D. A longer needle length
Correct Answer: B
Rationale: Engineered sharps-injury protection (retractable needles or hinged shields) covers or
retracts the needle immediately after use, significantly reducing percutaneous injury risk.
Question 8. A nurse sustains a needlestick from a used hollow-bore needle. What is the
immediate priority?
A. Apply a tourniquet proximal to the site
B. Squeeze the wound vigorously then bandage it
C. Ignore the injury if the client is low-risk
D. Wash the site thoroughly with soap and water and report the injury according to institutional
protocol
Correct Answer: D
Rationale: Immediate washing with soap and water, followed by prompt reporting and evaluation for
post-exposure prophylaxis, constitutes the first response to percutaneous exposure.
Question 9. Which isolation category requires a negative-pressure room and an N95
respirator?
HESI Milestone 2 Comprehensive Examination 2026/2027 | Verified Questions
HESI Milestone 2 Comprehensive
Examination 2026/2027 | Verified Questions
HESI / Elsevier | HESI Milestone 2 Comprehensive Examination | University-Level Nursing Students
100 Verified Questions | 4 Core Domains | Academic Year 2026/2027
Prepared by
HESI / Elsevier | HESI Milestone 2 Comprehensive Examination
Milestone 2 Comprehensive Examination Actual Exam | Academic Year 2026/2027
HESI Milestone 2 Comprehensive Examination 2026/2027 | Verified Questions
,INTRODUCTION
This Milestone 2 Comprehensive Examination contains 100 verified questions designed for university-
level nursing students preparing for the HESI Milestone 2 examination. The questions are distributed
equally across four core domains: Fundamentals of Nursing and Patient Safety (25 questions), Medical-
Surgical Nursing: Cardiovascular and Respiratory (25 questions), Medical-Surgical Nursing:
Gastrointestinal and Endocrine (25 questions), and Pharmacology and Medication Administration (25
questions). All content is original and constructed to reinforce the official HESI Milestone 2 course
objectives for actual exam readiness and clinical proficiency, aligned to the 2026/2027 academic year.
Each item emphasizes safe nursing care, pathophysiologic reasoning, and medication safety drawn from
foundational medical-surgical nursing methodology.
ACTUAL QUESTIONS
Domain 1: Fundamentals of Nursing and Patient Safety
Question 1. Which action is the single most effective method to prevent transmission of
infection in the healthcare setting?
A. Wearing sterile gloves for every client contact
B. Using a gown for all interactions
C. Performing hand hygiene before and after client contact and after touching potentially
contaminated surfaces
D. Administering prophylactic antibiotics to every client
Correct Answer: C
Rationale: Hand hygiene remains the cornerstone of infection prevention. Proper performance before
and after contact interrupts the chain of transmission more effectively than any other single measure.
Question 2. When is soap-and-water handwashing required instead of an alcohol-based
hand rub?
A. When hands are visibly soiled or after contact with Clostridium difficile or norovirus
B. Before entering any client room
C. After removing clean gloves only
D. Before preparing oral medications
Correct Answer: A
Rationale: Alcohol-based rubs are ineffective against spore-forming organisms such as C. difficile and
against norovirus when hands are heavily soiled. Visible soil or known exposure requires soap-and-
water washing.
Question 3. Which sequence is correct when removing contaminated personal protective
equipment?
A. Mask, goggles, gown, gloves
B. Gown first, then gloves
C. All items removed simultaneously
D. Gloves first, then gown, then eye protection, then mask or respirator
Correct Answer: D
Rationale: Removal begins with the most contaminated item (gloves), followed by gown, eye protection,
and finally the mask or respirator, minimizing self-contamination.
Question 4. A client is placed on contact precautions. Which PPE is required upon room
entry?
A. N95 respirator only
HESI Milestone 2 Comprehensive Examination 2026/2027 | Verified Questions
, B. Gown and gloves
C. Surgical mask and eye protection only
D. No PPE if contact is brief
Correct Answer: B
Rationale: Contact precautions require gown and gloves for all interactions that may involve contact
with the client or the client’s environment.
Question 5. Which statement correctly describes standard precautions?
A. They are used for all clients to protect against blood and body-fluid exposure regardless of
diagnosis
B. They apply only to clients with known infections
C. They replace the need for hand hygiene
D. They are required only during sterile procedures
Correct Answer: A
Rationale: Standard precautions treat all blood, body fluids, secretions, excretions (except sweat), non-
intact skin, and mucous membranes as potentially infectious and apply to every client.
Question 6. When preparing a sterile field, which action contaminates the field?
A. Opening the sterile package away from the body first
B. Keeping sterile gloved hands above the waist
C. Turning the back to the sterile field or allowing a non-sterile item to cross above it
D. Pouring sterile solution from a height of 4–6 inches
Correct Answer: C
Rationale: A sterile field is contaminated if it leaves the nurse’s line of sight or if a non-sterile object
passes over it. Continuous visual control is essential.
Question 7. Which needle-safety feature reduces the risk of needlestick injury after
injection?
A. A larger-gauge needle
B. A retractable or hinged needle shield that covers the needle after use
C. A reusable syringe barrel
D. A longer needle length
Correct Answer: B
Rationale: Engineered sharps-injury protection (retractable needles or hinged shields) covers or
retracts the needle immediately after use, significantly reducing percutaneous injury risk.
Question 8. A nurse sustains a needlestick from a used hollow-bore needle. What is the
immediate priority?
A. Apply a tourniquet proximal to the site
B. Squeeze the wound vigorously then bandage it
C. Ignore the injury if the client is low-risk
D. Wash the site thoroughly with soap and water and report the injury according to institutional
protocol
Correct Answer: D
Rationale: Immediate washing with soap and water, followed by prompt reporting and evaluation for
post-exposure prophylaxis, constitutes the first response to percutaneous exposure.
Question 9. Which isolation category requires a negative-pressure room and an N95
respirator?
HESI Milestone 2 Comprehensive Examination 2026/2027 | Verified Questions
