ACTUAL EXAM 2026-2027 COMPLETE ACCURATE EXAM
REAL QUESTIONS AND CORRECT VERIFIED ANSWERS
WITH DETAILED RATIONALES (100% RELIABLE ANSWERS)
CURRENTLY UPDATED VERSION EDITION 2026
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A 52-year-old woman presents with hot flashes, night sweats, and vaginal dryness.
She has a history of breast cancer treated with tamoxifen 5 years ago. Which of the
following is the most appropriate management for her vasomotor symptoms?
A) Systemic estrogen therapy
B) Vaginal estrogen cream
C) Selective serotonin reuptake inhibitor (SSRI)
D) Progestin-only therapy
ANSWER: C
,Rationale: In women with a history of breast cancer, systemic estrogen is
contraindicated. Vaginal estrogen may be considered for genitourinary symptoms
but is not first-line for vasomotor symptoms. SSRIs such as paroxetine or
venlafaxine are effective non-hormonal options for hot flashes. Progestins are not
typically used alone for vasomotor symptom management in this context.
A 48-year-old perimenopausal woman reports irregular menstrual cycles and mood
swings. Her FSH level is 25 mIU/mL. Which statement best characterizes her
menopausal status?
A) She is postmenopausal
B) She is in late perimenopause
C) She is in early perimenopause
D) She is premenopausal
ANSWER: C
Rationale: An FSH level of 25 mIU/mL in a woman with irregular cycles indicates
early perimenopause, as FSH levels begin to rise above 10-15 mIU/mL but remain
below 40 mIU/mL. Late perimenopause is characterized by FSH >40 mIU/mL and
more than 60 days of amenorrhea. Postmenopausal status is confirmed after 12
months of amenorrhea.
Which of the following is the most common cause of abnormal uterine bleeding in
perimenopausal women?
A) Endometrial hyperplasia
,B) Uterine fibroids
C) Anovulation
D) Endometrial polyps
ANSWER: C
Rationale: Anovulatory cycles are the most frequent etiology of abnormal uterine
bleeding in perimenopause due to declining ovarian function and unopposed
estrogen stimulation. While fibroids, polyps, and hyperplasia are important
differentials, anovulation accounts for the majority of cases.
A 55-year-old woman on hormone therapy (HT) with conjugated equine estrogens
and medroxyprogesterone acetate reports breast tenderness and mood irritability.
What is the most appropriate next step?
A) Discontinue HT immediately
B) Switch to transdermal estradiol with micronized progesterone
C) Reduce the estrogen dose
D) Add testosterone therapy
ANSWER: B
Rationale: Breast tenderness and mood changes are common side effects of oral
conjugated estrogens and progestins. Switching to a transdermal estradiol patch
with micronized progesterone may improve tolerability due to more physiological
hormone levels and fewer hepatic first-pass effects. Dose reduction may be
considered but switching formulations is often preferred.
, Which of the following is a contraindication to the use of systemic menopausal
hormone therapy?
A) Osteoporosis
B) Migraine with aura
C) Deep vein thrombosis (DVT) history
D) Hyperlipidemia
ANSWER: C
Rationale: A personal history of DVT is an absolute contraindication to systemic
hormone therapy due to increased thromboembolic risk. Migraine with aura is a
relative contraindication. Osteoporosis and hyperlipidemia are not
contraindications and may even benefit from HT.
A 60-year-old woman presents with dyspareunia and recurrent urinary tract
infections. She has not had a period for 10 years. Which therapy is most
appropriate for her genitourinary syndrome of menopause (GSM)?
A) Oral estrogen therapy
B) Vaginal estrogen tablets
C) Systemic progesterone
D) Tibolone
ANSWER: B