MMSC 436 PRACTICE QUIZ 9 - DRUGS &
TOXICOLOGY QUESTIONS WITH VERIFIED ANSWERS
When a drug concentration exceeds the available metabolic capacity of the body, what
does the drug's metabolism become dependent on?
-The amount of metabolizing enzyme
-The health of the renal system
-The number of doses given per hour
-The drug concentration itself - Answers - The amount of metabolizing enzyme
A carbonate salt of which drug is used to control manic-depressive disorders?
-Lithium
-Acetaminophen
-Phenytoin
-Digoxin - Answers - Lithium
Which of the following could account for drug toxicity following a prescribed dose?
-Using a single drug as opposed to multiple drugs for treatment
-Decreased renal elimination leading to increased free drug concentration
-Increased drug metabolism caused by central nervous system disease
-Using a different route of administration than is typically used for that drug - Answers -
Decreased renal elimination leading to increased free drug concentration
The fraction of drug absorbed into a physiological system that is based on the amount
of drug given is referred to as:
-volume of distribution.
-bioavailability.
-dosing.
-steady state. - Answers - bioavailability.
If a drug is acidic in nature, which of the following proteins will it associate with primarily
for transport and distribution?
-Lipoprotein
-α1-Glycoprotein
-Albumin
-All of the above - Answers - Albumin
The therapeutic range of a drug is:
-dependent on the route of drug administration.
-dependent on renal function.
-the range of concentrations within which the drug is effective yet not toxic.
, -the range of concentrations at which there are no drug interactions. - Answers - the
range of concentrations within which the drug is effective yet not toxic.
The period of time during which the concentration of a therapeutic drug decays by 50%
is referred to as the drug's:
-half-life.
-dosing curve.
-subtherapeutic range.
-volume of distribution. - Answers - half-life
The steady state of a drug is defined as the:
-time required for one-half of an administered drug to be lost through metabolism and
elimination.
-metabolism of a drug with a high hepatic extraction rate by the liver before it reaches
the systemic circulation.
-point at which the body concentration of the drug is in equilibrium with the rate of dose
administered and the rate of elimination.
-action of one drug on another. - Answers - point at which the body concentration of the
drug is in equilibrium with the rate of dose administered and the rate of elimination.
Respiratory alkalosis is a clinical feature of overdose ingestion of salicylate because:
-salicylates enhance anaerobic glycolysis.
-uncoupling of oxidative phosphorylation occurs in all cells.
-the central nervous system is stimulated to depress breathing.
-salicylates induce hyperventilation. - Answers - salicylates induce hyperventilation.
An individual is found unconscious with two empty pill bottles nearby, one of aspirin and
the other of phenobarbital. The best antidote for this type of double drug overdose
would be:
-forced alkaline diuresis.
-N-acetylcysteine.
-hemodialysis.
-atropine. - Answers - forced alkaline diuresis
An anticonvulsant used to control tonic-clonic (grand mal) seizures is:
-Lithium
-Digoxin
-Phenytoin
-Acetaminophen - Answers - Phenytoin
A drug that relaxes the smooth muscles of the bronchial passages is:
-Lithium
-Phenytoin
-Acetaminophen
-Theophylline - Answers - theophylline
TOXICOLOGY QUESTIONS WITH VERIFIED ANSWERS
When a drug concentration exceeds the available metabolic capacity of the body, what
does the drug's metabolism become dependent on?
-The amount of metabolizing enzyme
-The health of the renal system
-The number of doses given per hour
-The drug concentration itself - Answers - The amount of metabolizing enzyme
A carbonate salt of which drug is used to control manic-depressive disorders?
-Lithium
-Acetaminophen
-Phenytoin
-Digoxin - Answers - Lithium
Which of the following could account for drug toxicity following a prescribed dose?
-Using a single drug as opposed to multiple drugs for treatment
-Decreased renal elimination leading to increased free drug concentration
-Increased drug metabolism caused by central nervous system disease
-Using a different route of administration than is typically used for that drug - Answers -
Decreased renal elimination leading to increased free drug concentration
The fraction of drug absorbed into a physiological system that is based on the amount
of drug given is referred to as:
-volume of distribution.
-bioavailability.
-dosing.
-steady state. - Answers - bioavailability.
If a drug is acidic in nature, which of the following proteins will it associate with primarily
for transport and distribution?
-Lipoprotein
-α1-Glycoprotein
-Albumin
-All of the above - Answers - Albumin
The therapeutic range of a drug is:
-dependent on the route of drug administration.
-dependent on renal function.
-the range of concentrations within which the drug is effective yet not toxic.
, -the range of concentrations at which there are no drug interactions. - Answers - the
range of concentrations within which the drug is effective yet not toxic.
The period of time during which the concentration of a therapeutic drug decays by 50%
is referred to as the drug's:
-half-life.
-dosing curve.
-subtherapeutic range.
-volume of distribution. - Answers - half-life
The steady state of a drug is defined as the:
-time required for one-half of an administered drug to be lost through metabolism and
elimination.
-metabolism of a drug with a high hepatic extraction rate by the liver before it reaches
the systemic circulation.
-point at which the body concentration of the drug is in equilibrium with the rate of dose
administered and the rate of elimination.
-action of one drug on another. - Answers - point at which the body concentration of the
drug is in equilibrium with the rate of dose administered and the rate of elimination.
Respiratory alkalosis is a clinical feature of overdose ingestion of salicylate because:
-salicylates enhance anaerobic glycolysis.
-uncoupling of oxidative phosphorylation occurs in all cells.
-the central nervous system is stimulated to depress breathing.
-salicylates induce hyperventilation. - Answers - salicylates induce hyperventilation.
An individual is found unconscious with two empty pill bottles nearby, one of aspirin and
the other of phenobarbital. The best antidote for this type of double drug overdose
would be:
-forced alkaline diuresis.
-N-acetylcysteine.
-hemodialysis.
-atropine. - Answers - forced alkaline diuresis
An anticonvulsant used to control tonic-clonic (grand mal) seizures is:
-Lithium
-Digoxin
-Phenytoin
-Acetaminophen - Answers - Phenytoin
A drug that relaxes the smooth muscles of the bronchial passages is:
-Lithium
-Phenytoin
-Acetaminophen
-Theophylline - Answers - theophylline
