MMSC 436 EXAM 1 BS QUESTIONS WITH VERIFIED
ANSWERS
Which of the following statements concerning oncofetal antigens is incorrect?
a. Oncofetal antigens are sometimes glycoproteins.
b. An example of an oncofetal antigen is alpha-fetoprotein.
c. Oncofetal antigens are found as normal proteins in an embryo.
d. Oncofetal antigens are synthesized by placental trophoblasts. - Answers - d.
Oncofetal antigens are synthesized by placental trophoblasts.
Which of the following is NOT commonly used as a tumor marker?
a. Carcinoembryonic antigen
b. Cortisol
c. Alpha-fetoprotein
d. Prostate specific antigen - Answers - Cortisol
Clinical assays for tumor markers are most important for:
a. Confirming the absence of disease
b. Identifying patients at risk for cancer
c. Screening for the presence of cancer
d. Monitoring the course of a known cancer - Answers - d. Monitoring the course of a
known cancer
Proteins found in normal fetal tissue and also in certain tumors are referred to as:
a. embryonic proteins.
b. tumor-associated antigens.
c. oncofetal antigens.
d. oncogenes. - Answers - c. oncofetal antigens.
The properties of an ideal tumor marker include all of the following, except it should:
a. be specific for a given type of cancer.
b. be produced by tumor cells and detectable in body fluids.
c. not be present in healthy people.
d. be able to distinguish between benign and malignant tumors. - Answers - d. be able
to distinguish between benign and malignant tumors.
Follicular lymphoma occurs when the:
, a. bcl-2 gene on chromosome 18 is translocated to the immunoglobulin heavy chain
locus on chromosome 14.
b. c-myc gene becomes juxtaposed to the heavy-chain locus on chromosome 14.
c. HER-2/neu gene is overamplified, causing excess p105 to be released.
d. c-abl proto-oncogene and the BCR gene on a chromosome reciprocally translocate. -
Answers - a. bcl-2 gene on chromosome 18 is translocated to the immunoglobulin
heavy chain locus on chromosome 14.
A physical agent, such as exposure to ultraviolet light for an extended period of time, or
a biological agent, such as a virus, may cause cancer. These agents are referred to as:
a. tumor markers.
b. tumor suppressors.
c. oncogenes.
d. carcinogens. - Answers - d. carcinogens.
Proto-oncogenes are present in the human genome to serve the function of:
a. regulators of cell growth and proliferation.
b. directors of apoptosis.
c. repairmen of DNA.
d. virus suppressors. - Answers - a. regulators of cell growth and proliferation.
Which one of the following tumor markers is not a carbohydrate-related tumor marker
with its most important clinical use in the assessment of breast cancer recurrence?
a. CA 27.29
b. CA 125
c. CA 15-3
d. CA 549 - Answers - b. CA 125
Tumor-associated antigens composed of high-molecular-weight mucin-like
glycoproteins include:
a. p53 and Rb
b. BRCA-1 and -2
c. CA 125 and CA 19-9
d. PSA and AFP - Answers - c. CA 125 and CA 19-9
The most specific tumor marker for prostatic cancer is:
a. Human chorionic gonadotropin
b. Prostatic acid phosphatase
c. Prostate specific antigen
d. Alpha-fetoprotein - Answers - c. Prostate specific antigen
ANSWERS
Which of the following statements concerning oncofetal antigens is incorrect?
a. Oncofetal antigens are sometimes glycoproteins.
b. An example of an oncofetal antigen is alpha-fetoprotein.
c. Oncofetal antigens are found as normal proteins in an embryo.
d. Oncofetal antigens are synthesized by placental trophoblasts. - Answers - d.
Oncofetal antigens are synthesized by placental trophoblasts.
Which of the following is NOT commonly used as a tumor marker?
a. Carcinoembryonic antigen
b. Cortisol
c. Alpha-fetoprotein
d. Prostate specific antigen - Answers - Cortisol
Clinical assays for tumor markers are most important for:
a. Confirming the absence of disease
b. Identifying patients at risk for cancer
c. Screening for the presence of cancer
d. Monitoring the course of a known cancer - Answers - d. Monitoring the course of a
known cancer
Proteins found in normal fetal tissue and also in certain tumors are referred to as:
a. embryonic proteins.
b. tumor-associated antigens.
c. oncofetal antigens.
d. oncogenes. - Answers - c. oncofetal antigens.
The properties of an ideal tumor marker include all of the following, except it should:
a. be specific for a given type of cancer.
b. be produced by tumor cells and detectable in body fluids.
c. not be present in healthy people.
d. be able to distinguish between benign and malignant tumors. - Answers - d. be able
to distinguish between benign and malignant tumors.
Follicular lymphoma occurs when the:
, a. bcl-2 gene on chromosome 18 is translocated to the immunoglobulin heavy chain
locus on chromosome 14.
b. c-myc gene becomes juxtaposed to the heavy-chain locus on chromosome 14.
c. HER-2/neu gene is overamplified, causing excess p105 to be released.
d. c-abl proto-oncogene and the BCR gene on a chromosome reciprocally translocate. -
Answers - a. bcl-2 gene on chromosome 18 is translocated to the immunoglobulin
heavy chain locus on chromosome 14.
A physical agent, such as exposure to ultraviolet light for an extended period of time, or
a biological agent, such as a virus, may cause cancer. These agents are referred to as:
a. tumor markers.
b. tumor suppressors.
c. oncogenes.
d. carcinogens. - Answers - d. carcinogens.
Proto-oncogenes are present in the human genome to serve the function of:
a. regulators of cell growth and proliferation.
b. directors of apoptosis.
c. repairmen of DNA.
d. virus suppressors. - Answers - a. regulators of cell growth and proliferation.
Which one of the following tumor markers is not a carbohydrate-related tumor marker
with its most important clinical use in the assessment of breast cancer recurrence?
a. CA 27.29
b. CA 125
c. CA 15-3
d. CA 549 - Answers - b. CA 125
Tumor-associated antigens composed of high-molecular-weight mucin-like
glycoproteins include:
a. p53 and Rb
b. BRCA-1 and -2
c. CA 125 and CA 19-9
d. PSA and AFP - Answers - c. CA 125 and CA 19-9
The most specific tumor marker for prostatic cancer is:
a. Human chorionic gonadotropin
b. Prostatic acid phosphatase
c. Prostate specific antigen
d. Alpha-fetoprotein - Answers - c. Prostate specific antigen
