HNG 540 CERTIFICATION EVALUATION
TEST PAPER QUESTIONS AND SOLUTIONS
VERIFIED COMPLETE
●● Pharmacokinetics
Answer: what the body does to the drug
●● pharmacodynamics
Answer: what the drug does to the body
●● protein binding
Answer: the attachment of a drug molecule to a plasma or tissue protein,
effectively making the drug inactive but also keeping it within the body
●● Bioavailability
Answer: A measure of the extent of drug absorption for a given drug and
route (from 0% to 100%).
●● Advantage of minimal protein binding
Answer: better tissue penetration as there is more free drug available
●● disadvantage of minimal protein binding
,Answer: excreted much faster than a medication with a higher binding
level
●● What does protein binding effect?
Answer: distribution, metabolism, and elimination
●● Disadvantage of strongly bound protein drugs
Answer: will have lower concentration of free form drugs available for
interaction, leading to longer duration of action and low rates of
elimination
●● True/False the unbound form of a drug cannot exert any effect
Answer: False - the remaining unbound portion of a drug is the ONLY
portion that will exert any effect
●● A drug displays 60% protein binding? What percentage will exert an
effect?
Answer: 40% of the drug is free/unbound, meaning that only that 40%
will have an effect
●● What needs to be considered protein binding wise, when prescribing
medications?
Answer: -patients serum protein levels
- dose of medication
, ●● Why must dosing be considered when prescribing medications in
relation to protein binding?
Answer: this should be considered to ensure maximum drug amount is
available to have an effect on the body
●● What factor can influence gastric absorption when a drug is being
administered orally?
Answer: Lipid solubility
●● What type of drugs tend to be absorbed more efficiently in the GI
tract?
Answer: lipophilic drugs
●● Why do lipophilic drugs get absorbed more efficiently in the GI tract
and stomach?
Answer: this is due to cell membranes in the GI tract being composed of
lipids, allows these drugs to cross more freely
●● first pass metabolism
Answer: the substance degradation of an orally administered drug
caused by enzyme metabolism in the liver before the drug reaches the
systemic circulation
TEST PAPER QUESTIONS AND SOLUTIONS
VERIFIED COMPLETE
●● Pharmacokinetics
Answer: what the body does to the drug
●● pharmacodynamics
Answer: what the drug does to the body
●● protein binding
Answer: the attachment of a drug molecule to a plasma or tissue protein,
effectively making the drug inactive but also keeping it within the body
●● Bioavailability
Answer: A measure of the extent of drug absorption for a given drug and
route (from 0% to 100%).
●● Advantage of minimal protein binding
Answer: better tissue penetration as there is more free drug available
●● disadvantage of minimal protein binding
,Answer: excreted much faster than a medication with a higher binding
level
●● What does protein binding effect?
Answer: distribution, metabolism, and elimination
●● Disadvantage of strongly bound protein drugs
Answer: will have lower concentration of free form drugs available for
interaction, leading to longer duration of action and low rates of
elimination
●● True/False the unbound form of a drug cannot exert any effect
Answer: False - the remaining unbound portion of a drug is the ONLY
portion that will exert any effect
●● A drug displays 60% protein binding? What percentage will exert an
effect?
Answer: 40% of the drug is free/unbound, meaning that only that 40%
will have an effect
●● What needs to be considered protein binding wise, when prescribing
medications?
Answer: -patients serum protein levels
- dose of medication
, ●● Why must dosing be considered when prescribing medications in
relation to protein binding?
Answer: this should be considered to ensure maximum drug amount is
available to have an effect on the body
●● What factor can influence gastric absorption when a drug is being
administered orally?
Answer: Lipid solubility
●● What type of drugs tend to be absorbed more efficiently in the GI
tract?
Answer: lipophilic drugs
●● Why do lipophilic drugs get absorbed more efficiently in the GI tract
and stomach?
Answer: this is due to cell membranes in the GI tract being composed of
lipids, allows these drugs to cross more freely
●● first pass metabolism
Answer: the substance degradation of an orally administered drug
caused by enzyme metabolism in the liver before the drug reaches the
systemic circulation
