BLD 204 EXAM 2 UPDATED ACTUAL QUESTIONS AND
CORRECT ANSWERS
Question:
1. Cell-Mediated immunity
Answer:
MHC class 1 presents antigen to T cells (CD8+ T) which become active (and
proliferates) and stimulate apoptosis of the infected cell
Question:
2. Humoral Immunity
Answer:
B cells recognize antigen with their BCR and proliferate/ differentiate into plasma
cells and antibody production, which kill the antigens
Question:
3. Innate immunity
Answer:
made up of cells and mol. that are ALWAYS ready to provide defense. Not antigen
specific.
Question:
4. Adaptive immunity
Answer:
Cells and mol. that can respond to the "microbes that got away" from innate
protection. Specfic and powerful. (humoral and cell mediated)
Question:
5. Antigen
Answer:
molecules that are recognized as "non self" on the surface of cells (only epitope is
recognized).
can be endogenous (from host) or exogenous (from surrounding environment)
Question:
6. Antibody
Answer:
(immunoglobulins or Ig)
molecules produced in response to antigens
,Question:
7. Antibody structure
Answer:
2 identical heavy chains and 2 identical light chains
Question:
8. How many classes of antibodies are there? What are they
based on?
Answer:
5, based on heavy chain structure and how many monomeric units they have
Question:
9. Two types of light chains
Answer:
lambda or kappa
Question:
10. What do antibodies do?
Answer:
Agglutinate and lyse bacteria
Opsonize bacteria
Initiate classical complement pathway
Neutralize toxins
Block microbe entry into tissues
Assist in killing cells
Question:
11. What do APCs do? what kinds of cells are they?
Answer:
APCs capture and display the Ag "flag" in MHC class II molecules
-Dendritic cells
-macrophages
-B cells
Question:
12. Dendritic Cells
Answer:
-Capture and present antigen to T cells
-Express MHC Class II and T cell costimulatory molecules
-Found in T cell zones in lymphoid tissue
, Question:
13. Macrophages
Answer:
-Phagocytize and present antigens
Question:
14. B Cells as APCs
Answer:
Recognize AND present antigen
1.Recognize antigen via BCR
2. Take it in and process it
3. Present via MHC class II molecules to helper Ts
Question:
15. Cytokines in Innate immunity and inflammation
Answer:
TNF
IL-1
Chemokines
Question:
16. Cytokines in adaptive immunity
Answer:
IL-2
IL-4
IL-6
IL-10
IFN-gamma
Question:
17. Cytokines in Hematopoiesis
Answer:
GM-CSF
G-CSF
M-CSF
IL-3
CORRECT ANSWERS
Question:
1. Cell-Mediated immunity
Answer:
MHC class 1 presents antigen to T cells (CD8+ T) which become active (and
proliferates) and stimulate apoptosis of the infected cell
Question:
2. Humoral Immunity
Answer:
B cells recognize antigen with their BCR and proliferate/ differentiate into plasma
cells and antibody production, which kill the antigens
Question:
3. Innate immunity
Answer:
made up of cells and mol. that are ALWAYS ready to provide defense. Not antigen
specific.
Question:
4. Adaptive immunity
Answer:
Cells and mol. that can respond to the "microbes that got away" from innate
protection. Specfic and powerful. (humoral and cell mediated)
Question:
5. Antigen
Answer:
molecules that are recognized as "non self" on the surface of cells (only epitope is
recognized).
can be endogenous (from host) or exogenous (from surrounding environment)
Question:
6. Antibody
Answer:
(immunoglobulins or Ig)
molecules produced in response to antigens
,Question:
7. Antibody structure
Answer:
2 identical heavy chains and 2 identical light chains
Question:
8. How many classes of antibodies are there? What are they
based on?
Answer:
5, based on heavy chain structure and how many monomeric units they have
Question:
9. Two types of light chains
Answer:
lambda or kappa
Question:
10. What do antibodies do?
Answer:
Agglutinate and lyse bacteria
Opsonize bacteria
Initiate classical complement pathway
Neutralize toxins
Block microbe entry into tissues
Assist in killing cells
Question:
11. What do APCs do? what kinds of cells are they?
Answer:
APCs capture and display the Ag "flag" in MHC class II molecules
-Dendritic cells
-macrophages
-B cells
Question:
12. Dendritic Cells
Answer:
-Capture and present antigen to T cells
-Express MHC Class II and T cell costimulatory molecules
-Found in T cell zones in lymphoid tissue
, Question:
13. Macrophages
Answer:
-Phagocytize and present antigens
Question:
14. B Cells as APCs
Answer:
Recognize AND present antigen
1.Recognize antigen via BCR
2. Take it in and process it
3. Present via MHC class II molecules to helper Ts
Question:
15. Cytokines in Innate immunity and inflammation
Answer:
TNF
IL-1
Chemokines
Question:
16. Cytokines in adaptive immunity
Answer:
IL-2
IL-4
IL-6
IL-10
IFN-gamma
Question:
17. Cytokines in Hematopoiesis
Answer:
GM-CSF
G-CSF
M-CSF
IL-3
