NAGELHOUT PHARM 1 EXAM 3 UPDATED ACTUAL QUESTIONS AND CORRECT ANSWERS

NAGELHOUT PHARM 1 EXAM 3 UPDATED ACTUAL
QUESTIONS AND CORRECT ANSWERS

Question:
1. What is the least potent opiate?
Answer:
Codeine. Relative potency of 0.04 relative to morphine.

Question:
2. T or F. High dose opioids like sufentanil provide all of the requirement of general anesthesia?
Answer:
False. Supplemental drugs may be need to achieve amnesia/unconsciousness, relaxation and sympathetic
control.

Question:
3. What is the most potent opioid?
Answer:
Sufentanil 500-1000 as potent as morphine sulfate

Question:
4. Rank these drugs from least potent to most potent- Meperidine, Fentanil, Codeine, Alfentanil,
Sufentanil, Morphine, Remifentanil?
Answer:
1. Codeine 0.04
2. Meperidine 0.1
3. Morphine 1
4. Alfentanil 10
5. Fentanil 100
6. Remifentanil 100
7.Sufentanil 1,000

Question:
5. T or F. It's ok to give fentanyl to someone with morphine allergy.
Answer:
True. Fentanyl is a piperidine derivative. Morphine is phenantrene alkaloid. Cross allergy occurs to drugs
in the same classes

Question:
6. T or F. Morphine's metabolite has no significant analgesic activity?
Answer:
False. They have significant analgesic activity. Accumulation may occur with repetitive dosing in renal
patient.

Question:
7. Which class of opioids are best to give to asthmatics?

, Answer:
phenylpiperadines (i.e fentanil) (no histamine release)

Question:
8. Which opioid has a metabolite that is CNS toxic?
Answer:
Meperidine. metabolite (normeperidine) causes seizure. caution in patient with renal disease or the elderly
or when used repeatedly.

Question:
9. Which opioid is metabolized by non esterase dependent enzymes?
Answer:
Remifentanil This happens via hydrolysis of ester bonds in the blood plasma

Question:
10. What is the elimination half life of remifentanil?
Answer:
5-10 minutes

Question:
11. T or F. Remifentanil has anti shivering property?
Answer:
False. Only Meperidine has anti shivering property.

Question:
12. Which stimuli requires the highest dose narcotics to achieve no response: skin incision, skin closure,
intubation?
Answer:
Intubation

Question:
13. T or F. Opiates have anti-emetic properties.
Answer:
True. They inhibit vomiting center especially with repeated doses.

Question:
14. What receptors are responsible for the ventilatory depressing and analgesic effects of opiods?
Answer:
Mu

Question:
15. T or F. Naloxone is an antagonist at ALL opioid receptors?
Answer:
True.

Question:
16. A patient who's taking Monoamine oxidase inhibitor and has been given meperidine may suffer from?