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Core Domains:
1. Symptom Management and Supportive Care
2. Treatment Modalities
3. Oncologic Emergencies
4. Oncology Nursing Practice
5. Care Continuum
6. Psychosocial Dimensions of Care
Introduction:
The purpose of this examination is to rigorously assess the specialized knowledge, clinical
judgment, and competencies required of professional registered nurses providing
comprehensive care to adult oncology patients across the health continuum. This
evaluation measures critical skills spanning foundational scientific theory, advanced
treatment modalities, complex symptom management, and urgent complication
interventions. Featuring a challenging mix of multiple-choice and complex scenario-based
items, the assessment heavily emphasizes real-world application, safe clinical practice,
and evidence-based decision-making to ensure optimal patient outcomes, rigorous safety
standards, and professional accountability.
,SECTION ONE: QUESTIONS 1–100
Question 1
A patient with non-small cell lung cancer receiving a targeted tyrosine kinase inhibitor
reports severe, painful maculopapular rashes across the face and upper chest. Which
initial nursing intervention is most appropriate?
A. Discontinue the targeted therapy immediately and schedule an oncology provider visit
within two weeks.
B. Instruct the patient to scrub the affected areas daily with an antibacterial soap and apply
a heating pad.
C. Apply alcohol-free emollient creams, avoid direct sun exposure, and notify the provider
for possible topical or systemic therapy.
D. Reassure the patient that cutaneous toxicities resolve spontaneously without
intervention and encourage heavy makeup application.
🟢 C. Apply alcohol-free emollient creams, avoid direct sun exposure, and notify the
provider for possible topical or systemic therapy.
🔴 Explanation: Skin toxicities like acneiform rashes are common with EGFR inhibitors.
Management focuses on skin hydration with alcohol-free emollients, strict sun protection,
and provider notification for potential topical corticosteroids or oral antibiotics. Immediate
cessation is reserved for severe grades, and harsh scrubbing or heat worsens
inflammation.
Question 2
,A patient with acute myeloid leukemia undergoes induction chemotherapy and develops a
temperature of 38.8 degrees Celsius, absolute neutrophil count of 300 cells per microliter,
and mild hypotension. What is the priority nursing action?
A. Obtain blood cultures from all lumen lines and peripheral sites, then immediately initiate
broad-spectrum intravenous antibiotics.
B. Administer prescribed oral antipyretics and recheck the temperature in four hours before
reporting to the physician.
C. Draw a complete blood count and wait for the results confirmation before starting any
antimicrobial therapy.
D. Restrict oral fluid intake to prevent fluid overload secondary to potential chemotherapy-
induced nephrotoxicity.
🟢 A. Obtain blood cultures from all lumen lines and peripheral sites, then immediately
initiate broad-spectrum intravenous antibiotics.
🔴 Explanation: Febrile neutropenia is a medical emergency. Blood cultures must be
drawn promptly, and empiric broad-spectrum intravenous antibiotics must be administered
within one hour of presentation to prevent rapid clinical deterioration and septic shock.
Waiting for lab confirmation or delaying antibiotics is unsafe.
Question 3
A patient receiving high-dose cisplatin therapy exhibits a serum creatinine increase from
0.8 mg/dL to 2.2 mg/dL and a significant decrease in urine output. Which intervention
should the nurse anticipate?
, A. Immediate administration of a loop diuretic to force rapid glomerular filtration.
B. Hydration protocol adjustments with normal saline and electrolyte replacement, and
nephrology consultation.
C. Discontinuation of antiemetic support to decrease metabolic renal load.
D. Initiation of high-protein nutritional supplementation to support renal tissue repair.
🟢 B. Hydration protocol adjustments with normal saline and electrolyte replacement, and
nephrology consultation.
🔴 Explanation: Cisplatin is highly nephrotoxic, causing acute kidney injury through direct
tubular damage. Aggressive pre- and post-hydration with normal saline, electrolyte
management, and prompt nephrology involvement are vital to manage or reverse renal
injury. Forced diuresis with loop diuretics without adequate volume replacement can
worsen outcomes.
Question 4
During an infusion of paclitaxel, a patient develops sudden dyspnea, flushing, chest
tightness, and urticaria within minutes of starting the medication. What is the nurse's
immediate action?
A. Slow the infusion rate by half and administer a dose of oral diphenhydramine.
B. Stop the infusion immediately, maintain a patent intravenous line with normal saline, and
notify the provider.
C. Flush the line with heparinized saline and place the patient in a flat supine position.
D. Reassure the patient that mild infusion site reactions are expected and continue the
medication at baseline speed.