BIOC 384 D2Q 7TH EDITION WITH
COMPLETE QUESTIONS AND CORRECT
ANSWERS
When ATCase is in the __________ state it indicates that ____________ is bound, and that ATCase is
______________ regulated. - Correct Answer: T; CTP; down
The second messenger cyclic AMP (cAMP) is synthesized from ATP by the activity of the enzyme
adenylate cyclase. Cyclic AMP, in turn, activates proteins kinase A (PKA), which is responsible for most of
the effects of cAMP within the cell. Determine the correct steps in the activation of PKA, and then
number them in the correct order (1-5), starting after the adenylyl cyclase reaction.
The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues.
Cytosolic cAMP concentration increases.
Each regulatory subunit is activated as the two cAMP molecules are released.
Two cAMP molecules bind to each PKA regulatory subunit.
The regulatory subunits move out of the active sites of the catalytic subunits, and the R2C2 complex
dissociates. - Correct Answer: 1. Cytosolic cAMP concentration increases
2. Two cAMP molecules bind to each PKA regulatory subunit
3. The regulatory subunits move out of the active sites of the catalytic subunits, and the R2C2 complex
dissociates
4. The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues
5. Each regulatory subunit is activated as the two cAMP molecules are released
Put the following steps of the G protein cycle into the correct order.
GAPs stimulate the GTPase activity of G-alpha
Dissociation of G-alpha and G-beta/gamma from a GPCR
Ligand stimulation of the GEF function of a GPCR
Reassociation of the heterotrimeric G complex with a GPCR - Correct Answer: Ligand stimulation of the
GEF function of the GEF function of a GPCR
Dissociation of G-alpha and G-beta/gamma from a GPCR
COMPLETE QUESTIONS AND CORRECT
ANSWERS
When ATCase is in the __________ state it indicates that ____________ is bound, and that ATCase is
______________ regulated. - Correct Answer: T; CTP; down
The second messenger cyclic AMP (cAMP) is synthesized from ATP by the activity of the enzyme
adenylate cyclase. Cyclic AMP, in turn, activates proteins kinase A (PKA), which is responsible for most of
the effects of cAMP within the cell. Determine the correct steps in the activation of PKA, and then
number them in the correct order (1-5), starting after the adenylyl cyclase reaction.
The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues.
Cytosolic cAMP concentration increases.
Each regulatory subunit is activated as the two cAMP molecules are released.
Two cAMP molecules bind to each PKA regulatory subunit.
The regulatory subunits move out of the active sites of the catalytic subunits, and the R2C2 complex
dissociates. - Correct Answer: 1. Cytosolic cAMP concentration increases
2. Two cAMP molecules bind to each PKA regulatory subunit
3. The regulatory subunits move out of the active sites of the catalytic subunits, and the R2C2 complex
dissociates
4. The free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues
5. Each regulatory subunit is activated as the two cAMP molecules are released
Put the following steps of the G protein cycle into the correct order.
GAPs stimulate the GTPase activity of G-alpha
Dissociation of G-alpha and G-beta/gamma from a GPCR
Ligand stimulation of the GEF function of a GPCR
Reassociation of the heterotrimeric G complex with a GPCR - Correct Answer: Ligand stimulation of the
GEF function of the GEF function of a GPCR
Dissociation of G-alpha and G-beta/gamma from a GPCR
