AOCNP Review | Advanced Oncology Certified Nurse Practitioner Exam Study Guide

AOCNP./review


the./risk./for./significant./bone./marrow./suppression./(8)./-
./correct./answer./advanced./age./(>65),poor./nutritional./status,./preexist
ing./autoimmune./disease,./DM,./GI./disorders,./liver./disease,./or./hemat
opoietic./disease,./and./substance./abuse.


Cancer-induced./bone./marrow./suppression./(3)./-
./correct./answer./a)./dysfunctional./hematopoietic./cell./within./the./bon
e./marrow,./b)./bone./marrow./infiltration./with./tumor./c)general./exhau
stion./of./bone./marrow./reserves


solid./tumor./malignancies./with./the./highest./propensity./to./infiltrate./t
he./bone./marrow./in./the./course./of./metastasis./-
./correct./answer./melanoma,./cancer./of./the./breast,./lung,./kidney./and.
/prostate


Nitrosoureas./(Carmustine,./Lomustine)./-
./correct./answer./affect./the./pluripotent./stem./cell./(affecting./all./cell./l
ines/cell./cycle./nonspecific./agent)./use./for./glioblastoma./multiforme
severe./myelosuppression./may./last./up./to./85./days,./nadir./of./carmust
ine./occurs./in./26-60./days

,Radiation./induced./bone./marrow./suppression./occurs./when./(2)./-
./correct./answer./1../treatment./field./involves./marrow./producing./tissu
e./or./with./dose./greater./than./15./Gy


CD./4./counts./<./500/mm3./-
./correct./answer./significant./risk./factor./for./oopotunisitic./infections


Cyclosphosphamide./-./myelosuppression./risk./-
./correct./answer./moderate


Paclitaxel./-./myelosuppression./risk./-./correct./answer./moderate


Doxorubicin./(Adriamycin)./-./myelosuppression./risk./-
./correct./answer./alkylating./agnet,./may./produce./severe./myelosuppre
ssion,./the./duration./only./about./21./days


Myelosupression./secondary./to./radiation./therapy./peaks./at./-
./correct./answer./week./3
Suppression./may./occur./in./all./cell./lines./simultaneously./rather./than.
/sequentially./as./seen./with./chemotherapy
The./recovery./period./also./may./be./less./predictable.


Second./malignancy./:./Acute./leukemia./-
./potential./etiologic./factor./?./-

,./correct./answer./Alkylating./agent,./especially./with./high./doses./or./cu
mulative./doses./of./antimetabolites
Antitumor./antibiotics
Corticosteroids
Epipodophyllotoxins./(i.e./Etoposide)


Second./malignancy./:./Bladder./cancer-./potential./etiologic./factor./?./-
./correct./answer./radiation./therapy./for./prostate./cancer


Second./malignancy./:./Brain./tumors./-./potential./etiologic./factor./?./-
./correct./answer./therapeutic./radiation./for./other./cancer


Second./malignancy./:./hepatoma-./potential./etiologic./factor./?./-
./correct./answer./Androgen./therapy


Second./malignancy./:./Kidney./cancer./-./potential./etiologic./factor./?./-
./correct./answer./Brain./tumor./therapies
Cisplatin,./especially./in./treatment./for./testicular./cancer


Second./malignancy./:./Leukemia./-./potential./etiologic./factor./?./-
./correct./answer./Antitumor./antibiotics./
Brest./cancer./treatment./
Lymphoma./treatment./

, Post./transplant./immunosuppression
Prostate./cancer./treatment


Second./malignancy./:./Lung./cancer./-./potential./etiologic./factor./?./-
./correct./answer./HIV./infection./
Theraputic./radiation./for./other./cancers


Second./malignancy./:./Mesothelioma./-./potential./etiologic./factor./?./-
./correct./answer./Thoracic./radiation./for./lung./neoplasms


Second./malignancy./:./Neuroectodermal./tumors-
./potential./etiologic./factor./?./-
./correct./answer./Growth./hormone./replacement./after./children./cancer
s
Theraputic./radiation./for./other./cancers


Second./malignancy./:./Non-Hodgkin./Lymphoma-
./potential./etiologic./factor./?./-./correct./answer./Alkylating./agent./
Antimetabolites
Antitumor./antibiotics
Cyclosporine
Radiation./therapy
Tacrolimus