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NCLEX-RN 2026 Adult Medical-Surgical Nursing — 150 Practice Questions with Rationales

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NCLEX-RN 2026 Adult Medical-Surgical Nursing — 150 Practice Questions with Detailed Rationales Comprehensive NCLEX-RN study resource featuring 150 original practice questions with answers and detailed rationales. Covers cardiovascular, respiratory, neurological, renal, gastrointestinal, endocrine, musculoskeletal, oncology, infection control, pharmacology, prioritization, delegation, and clinical judgment. Disclaimer: This is an independently created educational resource and is not an official NCLEX-RN examination, NCSBN product, or leaked exam material.

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NCLEX-PN 2026 Comprehensive Prac ce
Test — 150 Ques ons with Detailed
Ra onales

1. A nurse is caring for a client who is at high risk for falls. Which intervention is
most appropriate?

A. Raise all four side rails.
B. Keep the bed in the lowest position.
C. Encourage the client to walk without assistance.
D. Place frequently used items out of reach.

Answer: B

Rationale: Keeping the bed low reduces the risk and severity of injury from a fall. Four raised
side rails may be considered a restraint.



2. Which action is the best method for preventing healthcare-associated
infections?

A. Wearing gloves at all times
B. Performing proper hand hygiene
C. Administering prophylactic antibiotics
D. Isolating every hospitalized client

Answer: B

Rationale: Proper hand hygiene is the single most effective intervention for preventing
transmission of infection.



3. A client has Clostridioides difficile infection. Which precaution is required?

A. Airborne precautions
B. Droplet precautions

,C. Contact precautions
D. Protective isolation

Answer: C

Rationale: C. difficile requires contact precautions. Soap and water should be used for hand
hygiene because alcohol-based sanitizer does not reliably destroy spores.



4. Which client should the nurse assess first?

A. A client requesting pain medication
B. A client with oxygen saturation of 88%
C. A client asking for assistance to the bathroom
D. A client waiting for discharge instructions

Answer: B

Rationale: Oxygen saturation of 88% indicates potential hypoxemia. Airway and breathing are
priority concerns.



5. Which position is appropriate for a client receiving an enema?

A. Supine
B. Right lateral
C. Left lateral Sims'
D. Trendelenburg

Answer: C

Rationale: The left lateral Sims' position follows the natural anatomical direction of the colon
and facilitates administration.



6. The nurse discovers that a medication error has occurred. What is the priority
action?

A. Complete an incident report.
B. Notify the healthcare provider.
C. Assess the client.
D. Inform the nurse manager.

,Answer: C

Rationale: The nurse must first assess the client for adverse effects. Client safety is always the
priority.



7. Which intervention helps prevent pressure injuries?

A. Massage reddened bony prominences
B. Reposition an immobile client regularly
C. Limit fluid intake
D. Use a donut-shaped cushion

Answer: B

Rationale: Regular repositioning decreases prolonged pressure and helps prevent tissue injury.



8. A client suddenly develops chest pain. What should the nurse do first?

A. Obtain a complete health history.
B. Assess vital signs and symptoms.
C. Administer an antacid.
D. Encourage the client to rest.

Answer: B

Rationale: Immediate assessment helps determine severity and guides emergency interventions.



9. Which finding should be reported immediately?

A. Temperature of 37°C (98.6°F)
B. Urine output of 15 mL/hr
C. Pulse of 76/min
D. Respirations of 18/min

Answer: B

Rationale: Urine output below approximately 30 mL/hr may indicate decreased renal perfusion
and requires prompt evaluation.

, 10. Which task can be delegated to an unlicensed assistive personnel (UAP)?

A. Assessing pain
B. Administering medication
C. Obtaining routine vital signs
D. Developing a care plan

Answer: C

Rationale: Routine, predictable tasks such as obtaining vital signs may be delegated to trained
UAP.



11. Which finding indicates a possible medication allergy?

A. Mild thirst
B. Urticaria and wheezing
C. Increased appetite
D. Bradycardia after exercise

Answer: B

Rationale: Hives and wheezing may indicate an allergic reaction or anaphylaxis.



12. A client is receiving oxygen through a nasal cannula. Which teaching is
appropriate?

A. Apply petroleum jelly inside the nostrils.
B. Avoid smoking near oxygen equipment.
C. Adjust the flow rate without an order.
D. Remove oxygen while sleeping.

Answer: B

Rationale: Oxygen supports combustion. Smoking and open flames must be avoided.



13. Which action demonstrates proper body mechanics?

A. Bend at the waist.
B. Hold objects away from the body.

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