Pharmacology Exam 1 verified questions with correct answers
A+ Grade
pharmacokinetics
- correct answer relationship between drug dosage and concentration in plasma over time, determines
onset, duration, and intensity of drug
pharmacodynamics
- correct answer relationship between drug concentration over time and therapeutic response
chemical specificity for receptors
- correct answer specificity between receptors and bonds, EX strict structural requirements for binding
receptor saturability
- correct answer only a finite number of receptors that can be occupied
receptor affinity
- correct answer measure of attraction between drug and receptor
drug potency
- correct answer dose required to have certain effect, related to affinity of receptor
ED50
- correct answer dose which produces 50% of maximum effect, used to compare drugs in terms of
potency
drug efficacy
- correct answer maximal effect achievable for a drug, related to number of receptor/complexes
formed, intrinsic activity of drug in activating receptor
, full agonist
- correct answer affinity to, and full activator, of receptor (high intrinsic activity/efficacy), increases
activity above basal level of receptor where receptor has a constitutive (intrinsic basal) level of activity in
the absence of a ligand
inverse agonist
- correct answer affinity to, and full activator of receptor (high intrinsic activity/efficacy), but has exact
opposite effect of full agonist (metoprolol), decreases activity below basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the absence of a ligand
partial agonist
- correct answer affinity to receptor but only partially activates a receptor, produces less than the ceiling
effect of a full agonist
pure antagonist
- correct answer affinity to receptor but produces no activation, dose curve is a straight line across the
bottom of an XY graph (EX oraverse vasodilates, overcoming the vasocontriction of the LA)
neutral antgonist
- correct answer has no activity in the absence of an agonist or inverse agonist but can block either's
activity
competitive antagonist
- correct answer lacks efficacy, competes with agonists for binding sites, inhibitory effect can be
overcome by increasing concentration of competing agonist
every drug produces a variety of effects, we hope we can get separation from things we want and
adverse side effects, this is different for every patient
- correct answer
know the second slide on page 10 of principles of drugs
- correct answer which drugs is most potent, least potenet, most efficient and least efficient
physiological antagonism
- correct answer stimulates competing/opposite physiological responses which counteract the effects of
A+ Grade
pharmacokinetics
- correct answer relationship between drug dosage and concentration in plasma over time, determines
onset, duration, and intensity of drug
pharmacodynamics
- correct answer relationship between drug concentration over time and therapeutic response
chemical specificity for receptors
- correct answer specificity between receptors and bonds, EX strict structural requirements for binding
receptor saturability
- correct answer only a finite number of receptors that can be occupied
receptor affinity
- correct answer measure of attraction between drug and receptor
drug potency
- correct answer dose required to have certain effect, related to affinity of receptor
ED50
- correct answer dose which produces 50% of maximum effect, used to compare drugs in terms of
potency
drug efficacy
- correct answer maximal effect achievable for a drug, related to number of receptor/complexes
formed, intrinsic activity of drug in activating receptor
, full agonist
- correct answer affinity to, and full activator, of receptor (high intrinsic activity/efficacy), increases
activity above basal level of receptor where receptor has a constitutive (intrinsic basal) level of activity in
the absence of a ligand
inverse agonist
- correct answer affinity to, and full activator of receptor (high intrinsic activity/efficacy), but has exact
opposite effect of full agonist (metoprolol), decreases activity below basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the absence of a ligand
partial agonist
- correct answer affinity to receptor but only partially activates a receptor, produces less than the ceiling
effect of a full agonist
pure antagonist
- correct answer affinity to receptor but produces no activation, dose curve is a straight line across the
bottom of an XY graph (EX oraverse vasodilates, overcoming the vasocontriction of the LA)
neutral antgonist
- correct answer has no activity in the absence of an agonist or inverse agonist but can block either's
activity
competitive antagonist
- correct answer lacks efficacy, competes with agonists for binding sites, inhibitory effect can be
overcome by increasing concentration of competing agonist
every drug produces a variety of effects, we hope we can get separation from things we want and
adverse side effects, this is different for every patient
- correct answer
know the second slide on page 10 of principles of drugs
- correct answer which drugs is most potent, least potenet, most efficient and least efficient
physiological antagonism
- correct answer stimulates competing/opposite physiological responses which counteract the effects of
