ANCC FAMILY NURSE PRACTITIONER
COMPREHENSIVE EXAM
PREPARATION QUESTIONS AND
ANSWERS
1. A 65-year-old male presents with a complaint of sudden onset of severe pain, redness, and
swelling in the first metatarsophalangeal joint. Which of the following is the most
appropriate initial treatment?
A. Allopurinol 100 mg daily
B. Colchicine 0.6 mg every hour until pain subsides
C. Prednisone 40 mg daily for 10 days
D. Indomethacin 50 mg three times daily
Answer: D
Conceptual Explanation: For an acute gout flare, NSAIDs like Indomethacin are first-line
treatment. Allopurinol is used for prevention and should not be started during an acute
attack. Colchicine dosing has changed to prevent toxicity.
,2. Which cranial nerve is primarily responsible for the sensation of the face and the motor
function of chewing?
A. CN IX (Glossopharyngeal)
B. CN VII (Facial)
C. CN V (Trigeminal)
D. CN XII (Hypoglossal)
Answer: C
Conceptual Explanation: The Trigeminal nerve (CN V) controls facial sensation and the
muscles of mastication (chewing).
3. A patient with a history of hypertension presents with a persistent dry cough after starting
a new medication. Which class of medication is most likely responsible?
A. Calcium Channel Blockers
B. ACE Inhibitors
C. Beta-Blockers
D. Thiazide Diuretics
Answer: B
Conceptual Explanation: ACE inhibitors are well-known for causing a dry, hacking cough
due to the accumulation of bradykinin.
, 4. In the context of evidence-based practice, which of the following is considered the highest
level of evidence?
A. Randomized Controlled Trials
B. Case-control studies
C. Expert opinion
D. Meta-analysis of systematic reviews
Answer: D
Conceptual Explanation: Meta-analyses and systematic reviews of RCTs are at the top of
the evidence hierarchy.
5. A 24-month-old child should typically be able to perform which of the following tasks?
A. Walk up and down stairs one step at a time
B. Tie their own shoelaces
C. Draw a square
D. Speak in 4- to 5-word sentences
Answer: A
Conceptual Explanation: By 24 months, children are expected to walk up and down stairs
one step at a time and use 2-word phrases.
COMPREHENSIVE EXAM
PREPARATION QUESTIONS AND
ANSWERS
1. A 65-year-old male presents with a complaint of sudden onset of severe pain, redness, and
swelling in the first metatarsophalangeal joint. Which of the following is the most
appropriate initial treatment?
A. Allopurinol 100 mg daily
B. Colchicine 0.6 mg every hour until pain subsides
C. Prednisone 40 mg daily for 10 days
D. Indomethacin 50 mg three times daily
Answer: D
Conceptual Explanation: For an acute gout flare, NSAIDs like Indomethacin are first-line
treatment. Allopurinol is used for prevention and should not be started during an acute
attack. Colchicine dosing has changed to prevent toxicity.
,2. Which cranial nerve is primarily responsible for the sensation of the face and the motor
function of chewing?
A. CN IX (Glossopharyngeal)
B. CN VII (Facial)
C. CN V (Trigeminal)
D. CN XII (Hypoglossal)
Answer: C
Conceptual Explanation: The Trigeminal nerve (CN V) controls facial sensation and the
muscles of mastication (chewing).
3. A patient with a history of hypertension presents with a persistent dry cough after starting
a new medication. Which class of medication is most likely responsible?
A. Calcium Channel Blockers
B. ACE Inhibitors
C. Beta-Blockers
D. Thiazide Diuretics
Answer: B
Conceptual Explanation: ACE inhibitors are well-known for causing a dry, hacking cough
due to the accumulation of bradykinin.
, 4. In the context of evidence-based practice, which of the following is considered the highest
level of evidence?
A. Randomized Controlled Trials
B. Case-control studies
C. Expert opinion
D. Meta-analysis of systematic reviews
Answer: D
Conceptual Explanation: Meta-analyses and systematic reviews of RCTs are at the top of
the evidence hierarchy.
5. A 24-month-old child should typically be able to perform which of the following tasks?
A. Walk up and down stairs one step at a time
B. Tie their own shoelaces
C. Draw a square
D. Speak in 4- to 5-word sentences
Answer: A
Conceptual Explanation: By 24 months, children are expected to walk up and down stairs
one step at a time and use 2-word phrases.
