https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
NR 293 ALT
Absorbed in intestines
Pass through liver to be metabolized (first pass)
Inactive matbolites
Absorption
Transports of a drug by the bloodstream to its site of action
Distribution
Heart
Liver
Kidneys
Areas of rapid distribution
Muscle
pg. 1
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
,https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
Skin
Fat
Areas of slow distribution
Excretion
The elimination of drugs from the body and the main organ responsible is the
kidney
Metabolism
Involves the alteration of a drug into either an inactive metabolite, a more soluble
compound, a more present active metabolite, or a less active metabolite
Liver
Organ most responsible for metabolism
Hepatic metabolism
Involves enzymes cytochrome 450 which target lipid soluble drugs
pg. 2
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
,https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
Renal excretion
Accomplished through glomerular filtration active tubular reabsorption, and
active tubular secretion
Biliary excretion
Drugs though this route are metabolized by the liver and released as bile and
eliminated in feces
Which medications route are absorbed the slower
Which medication routes are absorbed the fastest
Half-life
Described the tie required for half of a given drug to be removed from the body
pg. 3
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
, https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
I.e. a drug at peak level would be 100g after 8 hours would be reduced to 50g, 8
hours would be the half life
5 half lives
Considered to be removed from the body
Steady state
State in which the amount of drug removed via elimination is equal to the amount
of drug absorbed
1. Be sure to rotate area
2. Need to be applied at the same time each day
3. Clean site f old patch and new patch before admin
4. Activate it by holding your hand on the patch for about 10 sec
Transdermal patches
pg. 4
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
NR 293 ALT
Absorbed in intestines
Pass through liver to be metabolized (first pass)
Inactive matbolites
Absorption
Transports of a drug by the bloodstream to its site of action
Distribution
Heart
Liver
Kidneys
Areas of rapid distribution
Muscle
pg. 1
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
,https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
Skin
Fat
Areas of slow distribution
Excretion
The elimination of drugs from the body and the main organ responsible is the
kidney
Metabolism
Involves the alteration of a drug into either an inactive metabolite, a more soluble
compound, a more present active metabolite, or a less active metabolite
Liver
Organ most responsible for metabolism
Hepatic metabolism
Involves enzymes cytochrome 450 which target lipid soluble drugs
pg. 2
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
,https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
Renal excretion
Accomplished through glomerular filtration active tubular reabsorption, and
active tubular secretion
Biliary excretion
Drugs though this route are metabolized by the liver and released as bile and
eliminated in feces
Which medications route are absorbed the slower
Which medication routes are absorbed the fastest
Half-life
Described the tie required for half of a given drug to be removed from the body
pg. 3
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
, https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
I.e. a drug at peak level would be 100g after 8 hours would be reduced to 50g, 8
hours would be the half life
5 half lives
Considered to be removed from the body
Steady state
State in which the amount of drug removed via elimination is equal to the amount
of drug absorbed
1. Be sure to rotate area
2. Need to be applied at the same time each day
3. Clean site f old patch and new patch before admin
4. Activate it by holding your hand on the patch for about 10 sec
Transdermal patches
pg. 4
https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch https://www.stuvia.com/user/allatopnotch
