GMS 6401 STANDARD EXAMS ANSWERS AND
QUESTIONS SET A+
The kidney consists of specialized vascular and tubular structures (the nephron) which
collaborate in the production of urine: - ✔✔The glomerular capillary is surrounded by an
epithelial structure which forms the beginning of the tubule.
✔✔A diagnostic renal clearance experiment is conducted and the following steady state
(= equilibrium) measurements are obtained on a 34 year old male subject, weighing 60
kg (assume that the renal plasma flow (RPF) is the same as the effective renal plasma
flow (ERPF):
Urine inulin = 200 mg/100ml
Plasma inulin = 4 mg/100ml
Urine flow (V) = 2ml/min
Urine PAH = 1200 mg/100ml
Plasma PAH = 6 mg/100ml - ✔✔GFR = 100ml/min
✔✔Any substance which is freely filtered at the glomerulus, is reabsorbed and is not
secreted, will have a renal clearance that is: Choose one best answer. - ✔✔Less than
the clearance of inulin
✔✔An increased protein excretion (proteinuria) can indicate glomerular damage. Which
of the following changes are likely to cause proteinuria? Choose 1 best answer: -
✔✔Loss of nephrin from the epithelial slit pore diaphragm
✔✔Maintenance of a high glomerular filtration rate (GFR) is required for optimal kidney
function. Which of the following options would be most likely to associate with a below
optimal GFR in man? - ✔✔A low glomerular capillary water permeability
✔✔A selective increase in renal plasma flow (RPF) due to parallel relaxation of
theafferent and efferent arterioles leads to: (Choose one best answer.) - ✔✔A rise in
GFR with no change in filtration fraction
QUESTIONS SET A+
The kidney consists of specialized vascular and tubular structures (the nephron) which
collaborate in the production of urine: - ✔✔The glomerular capillary is surrounded by an
epithelial structure which forms the beginning of the tubule.
✔✔A diagnostic renal clearance experiment is conducted and the following steady state
(= equilibrium) measurements are obtained on a 34 year old male subject, weighing 60
kg (assume that the renal plasma flow (RPF) is the same as the effective renal plasma
flow (ERPF):
Urine inulin = 200 mg/100ml
Plasma inulin = 4 mg/100ml
Urine flow (V) = 2ml/min
Urine PAH = 1200 mg/100ml
Plasma PAH = 6 mg/100ml - ✔✔GFR = 100ml/min
✔✔Any substance which is freely filtered at the glomerulus, is reabsorbed and is not
secreted, will have a renal clearance that is: Choose one best answer. - ✔✔Less than
the clearance of inulin
✔✔An increased protein excretion (proteinuria) can indicate glomerular damage. Which
of the following changes are likely to cause proteinuria? Choose 1 best answer: -
✔✔Loss of nephrin from the epithelial slit pore diaphragm
✔✔Maintenance of a high glomerular filtration rate (GFR) is required for optimal kidney
function. Which of the following options would be most likely to associate with a below
optimal GFR in man? - ✔✔A low glomerular capillary water permeability
✔✔A selective increase in renal plasma flow (RPF) due to parallel relaxation of
theafferent and efferent arterioles leads to: (Choose one best answer.) - ✔✔A rise in
GFR with no change in filtration fraction
