lOMoARcPSD|50131128
Comprehensive Guide to Obstetric and Neonatal
Pharmacology and Care
Maternal Child Nursing
, lOMoARcPSD|50131128
Comprehensive Guide to Obstetric and
Neonatal Pharmacology and Care
Carboprost (Hemabate)
Carboprost is used for induction of labor, postpartum hemorrhage (PPH),
and midtrimester abortion by directly stimulating the myometrium to
cause uterine contractions. It is a prostaglandin/oxytocic that effectively
facilitates expulsion of the fetus or control of bleeding after delivery.
Mechanism of Action:
It causes uterine contractions by acting directly on the uterine smooth
muscle, leading to cervical dilation and expulsion of products of
conception or blood clots.
Therapeutic Effects:
Control of postpartum hemorrhage
Induction of labor or abortion
Dosing:
Intramuscular (IM): 250 mcg, may be repeated every 15-90 minutes, not
exceeding 2 mg total
Side Effects:
Gastrointestinal: Diarrhea, nausea
Uterine: Uterine rupture (serious risk)
Respiratory: Wheezing (especially in asthmatics)
Fever and chills (shivering)
Contraindications:
Acute pelvic inflammatory disease
, lOMoARcPSD|50131128
Active pulmonary, renal, or hepatic disease
Use cautiously in: uterine scarring, asthma, hypertension, diabetes,
seizure disorders
Nursing Interventions:
Monitor vital signs: blood pressure, heart rate, temperature
Observe vaginal discharge and signs of hemorrhage: increased bleeding,
hypotension, tachycardia, pallor
Assess contraction duration and uterine tone; notify if contractions are
absent or last >1 minute
Monitor for uterine rupture signs and manage accordingly
Additional:
High-risk medication requiring second nurse verification
No specific antidote available
Labetalol
Labetalol is a beta-adrenergic blocker indicated for hypertension
management during pregnancy and postpartum.
Mechanism of Action:
It blocks both beta1 (cardiac) and beta2 (pulmonary, vascular, uterine)
receptors, reducing heart rate and vascular resistance, leading to
decreased blood pressure.
Dosing:
Oral: 100 mg twice daily
IV: 20 mg (0.25 mg/kg), titrated as needed
Side Effects:
Orthostatic hypotension
Comprehensive Guide to Obstetric and Neonatal
Pharmacology and Care
Maternal Child Nursing
, lOMoARcPSD|50131128
Comprehensive Guide to Obstetric and
Neonatal Pharmacology and Care
Carboprost (Hemabate)
Carboprost is used for induction of labor, postpartum hemorrhage (PPH),
and midtrimester abortion by directly stimulating the myometrium to
cause uterine contractions. It is a prostaglandin/oxytocic that effectively
facilitates expulsion of the fetus or control of bleeding after delivery.
Mechanism of Action:
It causes uterine contractions by acting directly on the uterine smooth
muscle, leading to cervical dilation and expulsion of products of
conception or blood clots.
Therapeutic Effects:
Control of postpartum hemorrhage
Induction of labor or abortion
Dosing:
Intramuscular (IM): 250 mcg, may be repeated every 15-90 minutes, not
exceeding 2 mg total
Side Effects:
Gastrointestinal: Diarrhea, nausea
Uterine: Uterine rupture (serious risk)
Respiratory: Wheezing (especially in asthmatics)
Fever and chills (shivering)
Contraindications:
Acute pelvic inflammatory disease
, lOMoARcPSD|50131128
Active pulmonary, renal, or hepatic disease
Use cautiously in: uterine scarring, asthma, hypertension, diabetes,
seizure disorders
Nursing Interventions:
Monitor vital signs: blood pressure, heart rate, temperature
Observe vaginal discharge and signs of hemorrhage: increased bleeding,
hypotension, tachycardia, pallor
Assess contraction duration and uterine tone; notify if contractions are
absent or last >1 minute
Monitor for uterine rupture signs and manage accordingly
Additional:
High-risk medication requiring second nurse verification
No specific antidote available
Labetalol
Labetalol is a beta-adrenergic blocker indicated for hypertension
management during pregnancy and postpartum.
Mechanism of Action:
It blocks both beta1 (cardiac) and beta2 (pulmonary, vascular, uterine)
receptors, reducing heart rate and vascular resistance, leading to
decreased blood pressure.
Dosing:
Oral: 100 mg twice daily
IV: 20 mg (0.25 mg/kg), titrated as needed
Side Effects:
Orthostatic hypotension
