MLA SB A Qu estion B an k
Transfusion Reactions
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Transfusion Reactions Blood product transfusion complications
A 55-year-old man develops fever, loin pain, and hypotension shortly after starting a red cell transfusion. What is the most likely diagnosis?
A Delayed haemolytic transfusion reaction
B Anaphylaxis unrelated to blood group
C Transfusion-associated circulatory overload
D Febrile non-haemolytic transfusion reaction only
E Acute haemolytic transfusion reaction, most commonly due to ABO incompatibility
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Transfusion Reactions Blood product transfusion complications
A 55-year-old man develops fever, loin pain, and hypotension shortly after starting a red cell transfusion. What is the most likely diagnosis?
A Delayed haemolytic transfusion reaction
B Anaphylaxis unrelated to blood group
C Transfusion-associated circulatory overload
D Febrile non-haemolytic transfusion reaction only
E Acute haemolytic transfusion reaction, most commonly due to ABO incompatibility ✓ Correct
EXPLANATION
Acute haemolytic transfusion reactions, most commonly due to ABO incompatibility, present with fever, loin pain, and hypotension shortly after starting transfusion,
and require immediate cessation of the transfusion.
, BLOOD AND LY MPH Question 2 of 50
Transfusion Reactions Blood product transfusion complications
A 60-year-old woman develops an acute haemolytic transfusion reaction. What is the most appropriate immediate management?
Stop the transfusion immediately, maintain intravenous access, and provide supportive care (fluids, monitoring), alongside notifying the
A
transfusion laboratory
B Continue the transfusion at a slower rate
C Restart the transfusion once symptoms settle without further investigation
D Give antihistamines only and continue the transfusion
E No action is needed if she remains conscious
Select the single best answer.
Transfusion Reactions
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Transfusion Reactions Blood product transfusion complications
A 55-year-old man develops fever, loin pain, and hypotension shortly after starting a red cell transfusion. What is the most likely diagnosis?
A Delayed haemolytic transfusion reaction
B Anaphylaxis unrelated to blood group
C Transfusion-associated circulatory overload
D Febrile non-haemolytic transfusion reaction only
E Acute haemolytic transfusion reaction, most commonly due to ABO incompatibility
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Transfusion Reactions Blood product transfusion complications
A 55-year-old man develops fever, loin pain, and hypotension shortly after starting a red cell transfusion. What is the most likely diagnosis?
A Delayed haemolytic transfusion reaction
B Anaphylaxis unrelated to blood group
C Transfusion-associated circulatory overload
D Febrile non-haemolytic transfusion reaction only
E Acute haemolytic transfusion reaction, most commonly due to ABO incompatibility ✓ Correct
EXPLANATION
Acute haemolytic transfusion reactions, most commonly due to ABO incompatibility, present with fever, loin pain, and hypotension shortly after starting transfusion,
and require immediate cessation of the transfusion.
, BLOOD AND LY MPH Question 2 of 50
Transfusion Reactions Blood product transfusion complications
A 60-year-old woman develops an acute haemolytic transfusion reaction. What is the most appropriate immediate management?
Stop the transfusion immediately, maintain intravenous access, and provide supportive care (fluids, monitoring), alongside notifying the
A
transfusion laboratory
B Continue the transfusion at a slower rate
C Restart the transfusion once symptoms settle without further investigation
D Give antihistamines only and continue the transfusion
E No action is needed if she remains conscious
Select the single best answer.
