NSG 552 PSYCHOPHARMACOLOGY
EXAM 1 QUESTIONS AND ANSWERS
1. Which phase of pharmacokinetics involves the movement of a drug from its site of
administration into the bloodstream?
A. Metabolism
B. Distribution
C. Absorption
D. Elimination
Answer: C
Conceptual Explanation: Absorption is the process by which a drug enters the systemic
circulation from the site of administration.
2. A drug that binds to a receptor and produces the maximum biological response is known as
a:
A. Partial Agonist
B. Inverse Agonist
C. Antagonist
,D. Full Agonist
Answer: D
Conceptual Explanation: A full agonist has high efficacy and elicits the maximal possible
response from the receptor system.
3. Which CYP450 enzyme is significantly induced by cigarette smoking, potentially lowering
levels of Olanzapine and Clozapine?
A. CYP1A2
B. CYP3A4
C. CYP2D6
D. CYP2C19
Answer: A
Conceptual Explanation: Cigarette smoke contains polycyclic aromatic hydrocarbons that
induce CYP1A2, leading to faster metabolism of drugs like clozapine and olanzapine.
4. The ‘Steady State’ of a medication is typically reached after approximately how many half-
lives?
A. 4 to 5
B. 1 to 2
C. 7 to 8
D. 10 to 12
, Answer: A
Conceptual Explanation: It generally takes 4 to 5 half-lives of consistent dosing to reach
steady-state concentration in the plasma.
5. Which dopamine pathway is associated with the ‘negative symptoms’ of schizophrenia,
such as flat affect and cognitive impairment?
A. Mesocortical
B. Nigrostriatal
C. Tuberoinfundibular
D. Mesolimbic
Answer: A
Conceptual Explanation: Dopamine deficiency in the mesocortical pathway is believed to
be responsible for the negative and cognitive symptoms of schizophrenia.
6. Blockade of dopamine in which pathway leads to Extrapyramidal Symptoms (EPS)?
A. Mesolimbic
B. Nigrostriatal
C. Mesocortical
D. Tuberoinfundibular
Answer: B
EXAM 1 QUESTIONS AND ANSWERS
1. Which phase of pharmacokinetics involves the movement of a drug from its site of
administration into the bloodstream?
A. Metabolism
B. Distribution
C. Absorption
D. Elimination
Answer: C
Conceptual Explanation: Absorption is the process by which a drug enters the systemic
circulation from the site of administration.
2. A drug that binds to a receptor and produces the maximum biological response is known as
a:
A. Partial Agonist
B. Inverse Agonist
C. Antagonist
,D. Full Agonist
Answer: D
Conceptual Explanation: A full agonist has high efficacy and elicits the maximal possible
response from the receptor system.
3. Which CYP450 enzyme is significantly induced by cigarette smoking, potentially lowering
levels of Olanzapine and Clozapine?
A. CYP1A2
B. CYP3A4
C. CYP2D6
D. CYP2C19
Answer: A
Conceptual Explanation: Cigarette smoke contains polycyclic aromatic hydrocarbons that
induce CYP1A2, leading to faster metabolism of drugs like clozapine and olanzapine.
4. The ‘Steady State’ of a medication is typically reached after approximately how many half-
lives?
A. 4 to 5
B. 1 to 2
C. 7 to 8
D. 10 to 12
, Answer: A
Conceptual Explanation: It generally takes 4 to 5 half-lives of consistent dosing to reach
steady-state concentration in the plasma.
5. Which dopamine pathway is associated with the ‘negative symptoms’ of schizophrenia,
such as flat affect and cognitive impairment?
A. Mesocortical
B. Nigrostriatal
C. Tuberoinfundibular
D. Mesolimbic
Answer: A
Conceptual Explanation: Dopamine deficiency in the mesocortical pathway is believed to
be responsible for the negative and cognitive symptoms of schizophrenia.
6. Blockade of dopamine in which pathway leads to Extrapyramidal Symptoms (EPS)?
A. Mesolimbic
B. Nigrostriatal
C. Mesocortical
D. Tuberoinfundibular
Answer: B
