AOCNP ADVANCED ONCOLOGY
CERTIFIED NURSE PRACTITIONER
PRACTICE EXAM QUESTIONS AND
ANSWERS
1. A 55-year-old male with metastatic colorectal cancer is found to have a KRAS mutation in
exon 12. Which of the following treatments is contraindicated based on this genetic profile?
A. Cetuximab
B. Oxaliplatin
C. 5-Fluorouracil
D. Bevacizumab
Answer: A
Conceptual Explanation: Tumors with KRAS mutations in exon 12 or 13 are resistant to
EGFR inhibitors like cetuximab and panitumumab because the mutation keeps the
signaling pathway ‘on’ regardless of receptor blockade.
,2. In the management of Cytokine Release Syndrome (CRS) following CAR-T cell therapy,
which agent is the first-line monoclonal antibody used to target the interleukin-6 (IL-6)
receptor?
A. Infliximab
B. Rituximab
C. Tocilizumab
D. Pembrolizumab
Answer: C
Conceptual Explanation: Tocilizumab is the FDA-approved IL-6 receptor antagonist used
to manage severe or life-threatening CRS associated with CAR-T cell therapy.
3. Which electrolyte abnormality is most characteristic of Tumor Lysis Syndrome (TLS)?
A. Hypokalemia
B. Hypouricemia
C. Hypercalcemia
D. Hyperphosphatemia
Answer: D
Conceptual Explanation: TLS results in the rapid release of intracellular contents, leading
to hyperuricemia, hyperkalemia, hyperphosphatemia, and secondary hypocalcemia.
, 4. A patient receiving high-dose cisplatin is at the highest risk for which type of
chemotherapy-induced nausea and vomiting (CINV)?
A. Delayed emesis
B. Anticipatory emesis
C. Breakthrough emesis
D. Acute emesis
Answer: A
Conceptual Explanation: Cisplatin is highly emetogenic and is specifically notorious for
causing delayed emesis (occurring >24 hours after administration), requiring a multi-drug
antiemetic regimen.
5. Which of the following is the most appropriate initial treatment for a patient presenting
with Superior Vena Cava (SVC) Syndrome caused by a highly chemo-sensitive tumor like Small
Cell Lung Cancer (SCLC)?
A. Immediate surgical resection
B. Urgent radiation therapy
C. Systemic chemotherapy
D. Emergent stenting only
Answer: C
CERTIFIED NURSE PRACTITIONER
PRACTICE EXAM QUESTIONS AND
ANSWERS
1. A 55-year-old male with metastatic colorectal cancer is found to have a KRAS mutation in
exon 12. Which of the following treatments is contraindicated based on this genetic profile?
A. Cetuximab
B. Oxaliplatin
C. 5-Fluorouracil
D. Bevacizumab
Answer: A
Conceptual Explanation: Tumors with KRAS mutations in exon 12 or 13 are resistant to
EGFR inhibitors like cetuximab and panitumumab because the mutation keeps the
signaling pathway ‘on’ regardless of receptor blockade.
,2. In the management of Cytokine Release Syndrome (CRS) following CAR-T cell therapy,
which agent is the first-line monoclonal antibody used to target the interleukin-6 (IL-6)
receptor?
A. Infliximab
B. Rituximab
C. Tocilizumab
D. Pembrolizumab
Answer: C
Conceptual Explanation: Tocilizumab is the FDA-approved IL-6 receptor antagonist used
to manage severe or life-threatening CRS associated with CAR-T cell therapy.
3. Which electrolyte abnormality is most characteristic of Tumor Lysis Syndrome (TLS)?
A. Hypokalemia
B. Hypouricemia
C. Hypercalcemia
D. Hyperphosphatemia
Answer: D
Conceptual Explanation: TLS results in the rapid release of intracellular contents, leading
to hyperuricemia, hyperkalemia, hyperphosphatemia, and secondary hypocalcemia.
, 4. A patient receiving high-dose cisplatin is at the highest risk for which type of
chemotherapy-induced nausea and vomiting (CINV)?
A. Delayed emesis
B. Anticipatory emesis
C. Breakthrough emesis
D. Acute emesis
Answer: A
Conceptual Explanation: Cisplatin is highly emetogenic and is specifically notorious for
causing delayed emesis (occurring >24 hours after administration), requiring a multi-drug
antiemetic regimen.
5. Which of the following is the most appropriate initial treatment for a patient presenting
with Superior Vena Cava (SVC) Syndrome caused by a highly chemo-sensitive tumor like Small
Cell Lung Cancer (SCLC)?
A. Immediate surgical resection
B. Urgent radiation therapy
C. Systemic chemotherapy
D. Emergent stenting only
Answer: C
