Test Bank Pharmacology NA
Pharmacological (Hong Bang International University)
, Chapter 1: Pharmacology An Introduction
1. The study of drug absorption, distribution, metabolism, and 6. A drug that has the potential for abuse and is regulated by the
excretion is known as (LO 1.1) Drug Enforcement Agency is classified as a (LO 1.7)
A. pharmacotherapeutics study of the use of drugs in treating A. poison
B. pharmacodynamics study disease
of the action of drugs on living B. OTC drug
C. pharmacokinetics tissue C. prescription drug
D. pharmacy study of the amount of drug that is required to D. controlled substance
E. posology produce therapeutic effects E. nonproprietary drug
2. The medical situation when a particular drug should not be
administered is referred to as (LO 1.2) 7. Select the term that relates to the amount of drug administered
A. side effect to produce a therapeutic effect. (LO 1.1)
B. adverse effect A. posology
C. drug allergy B. toxicology
D. contraindication C. pharmacodynamics
E. antagonism D. pharmacotherapeutics
E. pharmacy
3. An unusual or unexpected drug reaction by an individual is 8. A medication that does not require a physician’s service to
known as (LO 1.5) obtain is referred to as (LO 1.6)
A. toxic effect drug A. trade
interaction between 2 drugs with opposite effects
B. antagonism poisoning
(blocking 1 another) B. nonproprietary
C. idiosyncrasy @ C. nonprescription
D. side effect expected harmful D. brand
E. drug allergyeffects
an individual becomes sensitized to a
E. generic
particular drug
4. The proprietary drug name supplied by a pharmaceutical 9. Which of the following could be categorized as an adverse
company is also referred to as the (LO 1.6) reaction? (LO 1.5)
shorter nonpropietary name which is
A. generic name commonly a contraction of the chemical A. idiosyncrasy
B. over-the-counter namename =nonprescription drugs which can be B. drug allergy
C. trade name purchased anywhere, do not required
C. teratogenicity
physician
D. chemical name exact D. carcinogenicity
E. none of these name E. all of these
5. The time from drug administration to the first observable drug 10. The time a drug continues to produce its effect is its (LO 1.4)
effect is known as the (LO 1.4) A. ED50
A. duration of action length of time drug produce its B. maximal response
B. onse t o f action effect
C. ceiling effect
C. ceiling effect maximal response-increase in dose is
meaningless D. onset of action
D. maximal response
E. duration of action @
E. ceiling effect
Chapter 2: Pharmacokinetics and Factors of Individual Variation
1. The drug administration route demonstrating the slowest onset 6. When a drug increases the rate of drug metabolism of other
of action is (LO 2.1) drugs, the process is termed (LO 2.2)
A. inhalation A. first-pass metabolism
B. transdermal B. enzyme induction
IV > Inhalation > IM > SC > buccal,
C. intramuscular aerosal, sublingual > rectal > oral > C. enzyme inhibition
D. sublingual transdermal D. enterohepatic cycling
E. intravenous E. microsomal inhibition
2. For drugs to cross the blood–brain barrier, they must be (LO 7. The rate of drug absorption would be increased by which of the
2.2) following? (LO 2.2)
A. ionized A. drug ionization
B. positively charged B. water solubility
C. water soluble cause the brain is composed of a C. positively charged drug
D. lipid soluble large amount of lipid and BBB is a D. negatively charged drug
E. negatively charged lipid barrier E. lipid solubility @
3. First-pass metabolism refers to the metabolism of drugs in the 8. Which factor of individual variation is dependent upon the
some drugs r metabolized significantly as
(LO 2.2) they pass through the liver the first time patient’s attitude toward treatment? (LO 2.4)
A. kidney A. weight
B. blood vessels B. age
C. liver C. genetic variation
D. heart D. placebo effect
E. adipose tissue E. gender
,4. Drug X has a half-life of 6 hours. How much drug is left in the 9. Which FDA pregnancy category would appear to be the safest
body 18 hours after an IV injection of 1200 mg? (LO 2.3) for a developing fetus? (LO 2.5)
A. 75 mg A. Category A
B. 150 mg 6h -> 600mg B. Category B
12h ->
C. 300 mg 300mg 18h - C. Category C
D. 600 mg > 150mg D. Category D
E. 900 mg E. Category X
5. Drugs that have demonstrated teratogenic effects in women are 10. Which type of drug interaction describes a combined effect
classified as Pregnancy Category (LO 2.5) equal to the sum of the individual effects of two drugs? (LO 2.6)
A. B not been performed in pregnant women, no risk on fetal A. summation
animal
have not been performed in pregnant women r animal/have
B. Cteratogenic potential to animal but unknown risk to fetus
B. synergism
C. Dhave adverse risk to C. antagonism
fetus
D. X D. incompatibility
E. NR @has not been
rated
E. none of these
Chapter 5: Introduction to the Autonomic Nervous System
1. Select the nerve–function combination that is correctly
5. Somatic nerves send nerve impulses to
matched.
A. smooth muscle
A. afferent nerve—conducts nerve impulses to peripheral organs
B. skeletal muscle
B. efferent nerve—conducts sensory nerve impulses
C. cardiac muscle
C. autonomic nerve—conducts nerve impulses to visceral organs
D. visceral organs
D. adrenergic nerve—conducts nerve impulses to skeletal muscle
E. somatic nerve—conducts nerve impulses to smooth muscle E. intestinal tract
2. Sympathetic activation produces all of the following effects 6. During the fight or flight reaction, the adrenal medulla
except predominately releases
A. relaxation of urinary bladder A. acetylcholine
B. increased heart rate B. norepinephrine
C. pupillary dilation C. epinephrine
D. bronchoconstriction D. dopamine
E. constriction of urinary sphincter E. serotonin
7. Choose the body function that is increased during the fight or
3. The sympathetic postganglionic nerve ending releases
flight reaction.
A. epinephrine
A. digestion
B. norepinephrine
C. acetylcholine B. urination
D. dopamine C. elimination
E. none of these D. bronchoconstriction
E. heart rate
4. The neurotransmitter released at both sympathetic and 8. Which of the following neurotransmitters is released from
parasympathetic ganglia is cholinergic nerves?
A. acetylcholine A. norepinephrine
B. dopamine B. epinephrine
C. epinephrine C. catecholamine
D. norepinephrine D. acetylcholine
E. serotonin E. serotonin
Chapter 6: Drugs Affecting the Sympathetic Nervous System
1. The main pharmacologic effect of norepinephrine on alpha-1
6. Metoprolol is classified as a(n) (LO 6.7)
receptors is (LO 6.2)
A. alpha-blocker
A. increased heart rate
B. nonselective beta-blocker
B. bronchodilation
C. selective beta-1 blocker
C. vasoconstriction
D. adrenergic neuronal blocker
D. contraction of urinary bladder
E. selective beta-2 blocker
E. increased force of myocardial contraction
2. The pharmacologic effect of IV metaraminol is (LO 6.4) 7. The mechanism of action of methyldopa is (LO 6.8)
A. vasodilation A. increased release of NE from adrenergic nerve ending
B. vasoconstriction B. alpha-1 receptor blocker
C. cardiac stimulation C. beta-1 receptor blocker
D. cardiac depression D. formation of a false transmitter in adrenergic nerve ending
The mechanism of action of guanethidine is to decreased release of epinephrine from adrenergic
nerve ending
, E. bronchodilation E. none of these
8. The drug of choice to treat acute allergic reactions is (LO 6.4,
3. Epinephrine stimulates (LO 6.2)
6.5)
A. alpha-1 receptors
A. norepinephrine
B. alpha-2 receptors
B. phenylephrine
C. beta-1 receptors
C. pseudoephedrine
D. beta-2 receptors
D. epinephrine
E. all of these
E. propranolol
9. Which of the following are actions of nonselective beta-
4. At therapeutic doses, albuterol stimulates (LO 6.5)
adrenergic blocking drugs? (LO 6.7)
A. alpha-1 receptors
A. decreasing heart rate
B. alpha-2 receptors
B. decreasing force of myocardial contraction
C. beta-1 receptors
C. vasoconstriction of skeletal muscle blood vessels
D. beta-2 receptors
D. lowering of blood pressure
E. all of these E. all of these
10. The actions of epinephrine (EPI) include which of the
5. Tamsulosin is indicated for treatment of (LO 6.6)
following? (LO 6.3, 6.5)
A. hypertension
A. bronchodilation
B. benign prostatic hyperplasia
B. vasoconstriction
C. slow heart rate
C. relaxation of uterus
D. cardiac arrhythmias
D. increased heart rate
E. asthma E. all of these
Chapter 7: Drugs Affecting the Parasympathetic Nervous System
1. Parasympathetic receptors located on the membranes of the
6. The antidote for atropine poisoning is (LO7.3)
internal organs are classified as (LO 7.2)
A. scopolamine
A. alpha-1
B. bethanechol
B. nicotinic-neural (Nn)
C. neostigmine
C. nicotinic-muscle (Nm)
D. physostigmine
D. muscarinic
E. dicyclomine
E. ganglionic
2. Select the pharmacologic effect produced by cholinergic drugs.
7. Tolterodine (Detrol) is indicated for the treatment of (LO 7.5)
(LO 7.3)
A. motion sickness
A. increased heart rate
B. relief of urinary incontinence
B. increased gastrointestinal motility
C. ophthalmic examinations
C. decreased urination
D. glaucoma
D. pupillary dilation
E. Alzheimer’s disease
E. bronchodilation
8. Select the effect(s) produced by anticholinergic drugs such as
3. Physostigmine (Eserine) is classified as a(n) (LO7.3)
atropine. (LO 7.5)
A. direct-acting cholinergic drug
A. mydriasis
B. reversible acetylcholinesterase inhibitor
B. bronchodilation
C. irreversible acetylcholinesterase inhibitor
C. cycloplegia
D. anticholinergic
D. sedation
E. ganglionic blocker
E. all of these
9. Pick the correct pharmacologic effect(s) of direct-acting
4. Symptoms of cholinergic drug overdosage include (LO7.3)
cholinergic drugs. (LO 7.3)
A. slow pulse rate
A. respiratory paralysis
B. increased urination
B. urinary retention
C. diarrhea
C. increased heart rate
D. sweating
D. bronchodilation
E. all of these E. none of these
5. Anticholinergic effects include all of the following except (LO 10. Which of the following would be a preferred treatment for
7.5) overactive bladder? (LO 7.6)
A. bronchodilation A. neostigmine
B. increased heart rate B. tolterodine
C. increased gastrointestinal activity C. physostigmine
D. decreased respiratory secretions D. bethanechol
E. dry mouth E. donepezil
Pharmacological (Hong Bang International University)
, Chapter 1: Pharmacology An Introduction
1. The study of drug absorption, distribution, metabolism, and 6. A drug that has the potential for abuse and is regulated by the
excretion is known as (LO 1.1) Drug Enforcement Agency is classified as a (LO 1.7)
A. pharmacotherapeutics study of the use of drugs in treating A. poison
B. pharmacodynamics study disease
of the action of drugs on living B. OTC drug
C. pharmacokinetics tissue C. prescription drug
D. pharmacy study of the amount of drug that is required to D. controlled substance
E. posology produce therapeutic effects E. nonproprietary drug
2. The medical situation when a particular drug should not be
administered is referred to as (LO 1.2) 7. Select the term that relates to the amount of drug administered
A. side effect to produce a therapeutic effect. (LO 1.1)
B. adverse effect A. posology
C. drug allergy B. toxicology
D. contraindication C. pharmacodynamics
E. antagonism D. pharmacotherapeutics
E. pharmacy
3. An unusual or unexpected drug reaction by an individual is 8. A medication that does not require a physician’s service to
known as (LO 1.5) obtain is referred to as (LO 1.6)
A. toxic effect drug A. trade
interaction between 2 drugs with opposite effects
B. antagonism poisoning
(blocking 1 another) B. nonproprietary
C. idiosyncrasy @ C. nonprescription
D. side effect expected harmful D. brand
E. drug allergyeffects
an individual becomes sensitized to a
E. generic
particular drug
4. The proprietary drug name supplied by a pharmaceutical 9. Which of the following could be categorized as an adverse
company is also referred to as the (LO 1.6) reaction? (LO 1.5)
shorter nonpropietary name which is
A. generic name commonly a contraction of the chemical A. idiosyncrasy
B. over-the-counter namename =nonprescription drugs which can be B. drug allergy
C. trade name purchased anywhere, do not required
C. teratogenicity
physician
D. chemical name exact D. carcinogenicity
E. none of these name E. all of these
5. The time from drug administration to the first observable drug 10. The time a drug continues to produce its effect is its (LO 1.4)
effect is known as the (LO 1.4) A. ED50
A. duration of action length of time drug produce its B. maximal response
B. onse t o f action effect
C. ceiling effect
C. ceiling effect maximal response-increase in dose is
meaningless D. onset of action
D. maximal response
E. duration of action @
E. ceiling effect
Chapter 2: Pharmacokinetics and Factors of Individual Variation
1. The drug administration route demonstrating the slowest onset 6. When a drug increases the rate of drug metabolism of other
of action is (LO 2.1) drugs, the process is termed (LO 2.2)
A. inhalation A. first-pass metabolism
B. transdermal B. enzyme induction
IV > Inhalation > IM > SC > buccal,
C. intramuscular aerosal, sublingual > rectal > oral > C. enzyme inhibition
D. sublingual transdermal D. enterohepatic cycling
E. intravenous E. microsomal inhibition
2. For drugs to cross the blood–brain barrier, they must be (LO 7. The rate of drug absorption would be increased by which of the
2.2) following? (LO 2.2)
A. ionized A. drug ionization
B. positively charged B. water solubility
C. water soluble cause the brain is composed of a C. positively charged drug
D. lipid soluble large amount of lipid and BBB is a D. negatively charged drug
E. negatively charged lipid barrier E. lipid solubility @
3. First-pass metabolism refers to the metabolism of drugs in the 8. Which factor of individual variation is dependent upon the
some drugs r metabolized significantly as
(LO 2.2) they pass through the liver the first time patient’s attitude toward treatment? (LO 2.4)
A. kidney A. weight
B. blood vessels B. age
C. liver C. genetic variation
D. heart D. placebo effect
E. adipose tissue E. gender
,4. Drug X has a half-life of 6 hours. How much drug is left in the 9. Which FDA pregnancy category would appear to be the safest
body 18 hours after an IV injection of 1200 mg? (LO 2.3) for a developing fetus? (LO 2.5)
A. 75 mg A. Category A
B. 150 mg 6h -> 600mg B. Category B
12h ->
C. 300 mg 300mg 18h - C. Category C
D. 600 mg > 150mg D. Category D
E. 900 mg E. Category X
5. Drugs that have demonstrated teratogenic effects in women are 10. Which type of drug interaction describes a combined effect
classified as Pregnancy Category (LO 2.5) equal to the sum of the individual effects of two drugs? (LO 2.6)
A. B not been performed in pregnant women, no risk on fetal A. summation
animal
have not been performed in pregnant women r animal/have
B. Cteratogenic potential to animal but unknown risk to fetus
B. synergism
C. Dhave adverse risk to C. antagonism
fetus
D. X D. incompatibility
E. NR @has not been
rated
E. none of these
Chapter 5: Introduction to the Autonomic Nervous System
1. Select the nerve–function combination that is correctly
5. Somatic nerves send nerve impulses to
matched.
A. smooth muscle
A. afferent nerve—conducts nerve impulses to peripheral organs
B. skeletal muscle
B. efferent nerve—conducts sensory nerve impulses
C. cardiac muscle
C. autonomic nerve—conducts nerve impulses to visceral organs
D. visceral organs
D. adrenergic nerve—conducts nerve impulses to skeletal muscle
E. somatic nerve—conducts nerve impulses to smooth muscle E. intestinal tract
2. Sympathetic activation produces all of the following effects 6. During the fight or flight reaction, the adrenal medulla
except predominately releases
A. relaxation of urinary bladder A. acetylcholine
B. increased heart rate B. norepinephrine
C. pupillary dilation C. epinephrine
D. bronchoconstriction D. dopamine
E. constriction of urinary sphincter E. serotonin
7. Choose the body function that is increased during the fight or
3. The sympathetic postganglionic nerve ending releases
flight reaction.
A. epinephrine
A. digestion
B. norepinephrine
C. acetylcholine B. urination
D. dopamine C. elimination
E. none of these D. bronchoconstriction
E. heart rate
4. The neurotransmitter released at both sympathetic and 8. Which of the following neurotransmitters is released from
parasympathetic ganglia is cholinergic nerves?
A. acetylcholine A. norepinephrine
B. dopamine B. epinephrine
C. epinephrine C. catecholamine
D. norepinephrine D. acetylcholine
E. serotonin E. serotonin
Chapter 6: Drugs Affecting the Sympathetic Nervous System
1. The main pharmacologic effect of norepinephrine on alpha-1
6. Metoprolol is classified as a(n) (LO 6.7)
receptors is (LO 6.2)
A. alpha-blocker
A. increased heart rate
B. nonselective beta-blocker
B. bronchodilation
C. selective beta-1 blocker
C. vasoconstriction
D. adrenergic neuronal blocker
D. contraction of urinary bladder
E. selective beta-2 blocker
E. increased force of myocardial contraction
2. The pharmacologic effect of IV metaraminol is (LO 6.4) 7. The mechanism of action of methyldopa is (LO 6.8)
A. vasodilation A. increased release of NE from adrenergic nerve ending
B. vasoconstriction B. alpha-1 receptor blocker
C. cardiac stimulation C. beta-1 receptor blocker
D. cardiac depression D. formation of a false transmitter in adrenergic nerve ending
The mechanism of action of guanethidine is to decreased release of epinephrine from adrenergic
nerve ending
, E. bronchodilation E. none of these
8. The drug of choice to treat acute allergic reactions is (LO 6.4,
3. Epinephrine stimulates (LO 6.2)
6.5)
A. alpha-1 receptors
A. norepinephrine
B. alpha-2 receptors
B. phenylephrine
C. beta-1 receptors
C. pseudoephedrine
D. beta-2 receptors
D. epinephrine
E. all of these
E. propranolol
9. Which of the following are actions of nonselective beta-
4. At therapeutic doses, albuterol stimulates (LO 6.5)
adrenergic blocking drugs? (LO 6.7)
A. alpha-1 receptors
A. decreasing heart rate
B. alpha-2 receptors
B. decreasing force of myocardial contraction
C. beta-1 receptors
C. vasoconstriction of skeletal muscle blood vessels
D. beta-2 receptors
D. lowering of blood pressure
E. all of these E. all of these
10. The actions of epinephrine (EPI) include which of the
5. Tamsulosin is indicated for treatment of (LO 6.6)
following? (LO 6.3, 6.5)
A. hypertension
A. bronchodilation
B. benign prostatic hyperplasia
B. vasoconstriction
C. slow heart rate
C. relaxation of uterus
D. cardiac arrhythmias
D. increased heart rate
E. asthma E. all of these
Chapter 7: Drugs Affecting the Parasympathetic Nervous System
1. Parasympathetic receptors located on the membranes of the
6. The antidote for atropine poisoning is (LO7.3)
internal organs are classified as (LO 7.2)
A. scopolamine
A. alpha-1
B. bethanechol
B. nicotinic-neural (Nn)
C. neostigmine
C. nicotinic-muscle (Nm)
D. physostigmine
D. muscarinic
E. dicyclomine
E. ganglionic
2. Select the pharmacologic effect produced by cholinergic drugs.
7. Tolterodine (Detrol) is indicated for the treatment of (LO 7.5)
(LO 7.3)
A. motion sickness
A. increased heart rate
B. relief of urinary incontinence
B. increased gastrointestinal motility
C. ophthalmic examinations
C. decreased urination
D. glaucoma
D. pupillary dilation
E. Alzheimer’s disease
E. bronchodilation
8. Select the effect(s) produced by anticholinergic drugs such as
3. Physostigmine (Eserine) is classified as a(n) (LO7.3)
atropine. (LO 7.5)
A. direct-acting cholinergic drug
A. mydriasis
B. reversible acetylcholinesterase inhibitor
B. bronchodilation
C. irreversible acetylcholinesterase inhibitor
C. cycloplegia
D. anticholinergic
D. sedation
E. ganglionic blocker
E. all of these
9. Pick the correct pharmacologic effect(s) of direct-acting
4. Symptoms of cholinergic drug overdosage include (LO7.3)
cholinergic drugs. (LO 7.3)
A. slow pulse rate
A. respiratory paralysis
B. increased urination
B. urinary retention
C. diarrhea
C. increased heart rate
D. sweating
D. bronchodilation
E. all of these E. none of these
5. Anticholinergic effects include all of the following except (LO 10. Which of the following would be a preferred treatment for
7.5) overactive bladder? (LO 7.6)
A. bronchodilation A. neostigmine
B. increased heart rate B. tolterodine
C. increased gastrointestinal activity C. physostigmine
D. decreased respiratory secretions D. bethanechol
E. dry mouth E. donepezil
