NGR 6172 LIPPINCOTT STUDY QUESTIONS | COMPREHENSIVE NURSING STUDY
GUIDE, PRACTICE QUESTIONS & ANSWERS 2026/2027
40.1 A 68-year-old patient with cardiac failure is diagnosed with ovarian cancer. She begins using
cisplatin but becomes nauseous and suffers from severe vomiting. Which drug would be most effective
to counteract the emesis in this patient without exacerbating her cardiac problem?
A. Droperidol
B. Dolasetron
C. Prochlorperazine
D. Palonosetron - ANS ✔✔Correct answer = D.
Palonosetron is a 5-HT3 antagonist that is effective against drugs with high emetogenic
activity, such as cisplatin. Although dolasetron is also in this category, its propensity to affect the heart
makes it a poor choice for this patient. Droperidol is only a moderately effective antiemetic and has the
potential to prolong the QTc interval, so it is not preferred in this patient. The antiemetic effect of
prochlorperazine, a phenothiazine, is most beneficial against anticancer drugs with moderate to low
emetogenic properties.
40.2 A 45-year-old woman complains of severe persistent heartburn and an unpleasant, acid-like taste in
her mouth. The clinician suspects that she has gastroesophageal reflux disease. Which drug is most
appropriate?
A. An antacid such as aluminum hydroxide
B. Dicyclomine
C. Granisetron
D. Esomeprazole - ANS ✔✔Correct answer = D.
It is appropriate to treat this patient with a proton-pump inhibitor (PPI) to reduce acid production and
promote healing. An H2 receptor antagonist might also be effective, but the PPIs are preferred. An
antacid would decrease gastric acid, but its effects are short lived compared to those of the PPIs and H2
receptor antagonists. Dicyclomine is an antimuscarinic drug that is mainly used as an antispasmodic for
IBS. The 5-HT3 receptor antagonist granisetron is an antiemetic, and not appropriate for the treatment
of GERD.
40.3 A couple celebrating their 30th wedding anniversary are given a trip to Peru to visit Machu Picchu.
Because of past experiences while traveling, they ask their doctor to prescribe an agent in case they
experience diarrhea. Which drug would be effective?
A. Omeprazole
B. Loperamide
C. Famotidine
D. Lubiprostone - ANS ✔✔Correct answer = B.
Loperamide is the only drug that has antidiarrheal activity. Omeprazole is a proton-pump inhibitor,
famotidine antagonizes the H2 receptor to reduce acid production, and lubiprostone is indicated for
chronic constipation or IBS-C.
40.4 A 27-year-old woman who is 34 weeks' pregnant is on bed rest and is experiencing mild
constipation. Which drug is most appropriate for her?
A. Castor oil
B. Docusate
GUIDE, PRACTICE QUESTIONS & ANSWERS 2026/2027
40.1 A 68-year-old patient with cardiac failure is diagnosed with ovarian cancer. She begins using
cisplatin but becomes nauseous and suffers from severe vomiting. Which drug would be most effective
to counteract the emesis in this patient without exacerbating her cardiac problem?
A. Droperidol
B. Dolasetron
C. Prochlorperazine
D. Palonosetron - ANS ✔✔Correct answer = D.
Palonosetron is a 5-HT3 antagonist that is effective against drugs with high emetogenic
activity, such as cisplatin. Although dolasetron is also in this category, its propensity to affect the heart
makes it a poor choice for this patient. Droperidol is only a moderately effective antiemetic and has the
potential to prolong the QTc interval, so it is not preferred in this patient. The antiemetic effect of
prochlorperazine, a phenothiazine, is most beneficial against anticancer drugs with moderate to low
emetogenic properties.
40.2 A 45-year-old woman complains of severe persistent heartburn and an unpleasant, acid-like taste in
her mouth. The clinician suspects that she has gastroesophageal reflux disease. Which drug is most
appropriate?
A. An antacid such as aluminum hydroxide
B. Dicyclomine
C. Granisetron
D. Esomeprazole - ANS ✔✔Correct answer = D.
It is appropriate to treat this patient with a proton-pump inhibitor (PPI) to reduce acid production and
promote healing. An H2 receptor antagonist might also be effective, but the PPIs are preferred. An
antacid would decrease gastric acid, but its effects are short lived compared to those of the PPIs and H2
receptor antagonists. Dicyclomine is an antimuscarinic drug that is mainly used as an antispasmodic for
IBS. The 5-HT3 receptor antagonist granisetron is an antiemetic, and not appropriate for the treatment
of GERD.
40.3 A couple celebrating their 30th wedding anniversary are given a trip to Peru to visit Machu Picchu.
Because of past experiences while traveling, they ask their doctor to prescribe an agent in case they
experience diarrhea. Which drug would be effective?
A. Omeprazole
B. Loperamide
C. Famotidine
D. Lubiprostone - ANS ✔✔Correct answer = B.
Loperamide is the only drug that has antidiarrheal activity. Omeprazole is a proton-pump inhibitor,
famotidine antagonizes the H2 receptor to reduce acid production, and lubiprostone is indicated for
chronic constipation or IBS-C.
40.4 A 27-year-old woman who is 34 weeks' pregnant is on bed rest and is experiencing mild
constipation. Which drug is most appropriate for her?
A. Castor oil
B. Docusate
