ONS ONCC
Chemo Certification Renewal | Practice Questions,
Answers & Detailed Rationales | 2026/2027
Resource Features
➢ ONS/ONCC renewal-focused practice questions
➢ Answers for self-assessment
➢ Detailed rationales
➢ Oncology clinical scenarios
➢ Chemotherapy review
➢ Immunotherapy review
,Chemo Certification Renewal | Practice Questions,
Answers & Detailed Rationales | 2026/2027
Question 1
The standard states that gowns must:
A. be disposable
B. not have any closures or seams that HDs can pass through
C. be changed every shift if there are no specific manufacturer
recommendations
D. both a & b
Answer: D. both a & b
Rationale: USP <800> standards require that gowns used for
hazardous drug (HD) handling must be disposable and must not
have any closures or seams that could allow hazardous drugs to
penetrate through. These requirements are designed to provide a
complete barrier between the healthcare worker and potentially
harmful drug exposure. While changing gowns regularly is
important, the standard specifically mandates the disposable
nature and seam/closure integrity of gowns used for HD handling.
, Question 2
Which of the following is a general recommendation regarding
the administration of hazardous drugs?
A. A NIOSH-approved respirator is required for all intravenous
administration.
B. Reuse of gowns is appropriate if the gown remains hung up in
the same area all the time.
C. Wash hands with soap and water instead of using alcohol-
based hand gel.
D. Unspike hazardous drug bottles or bags and place in
hazardous container with tubing separate.
Answer: C. Wash hands with soap and water instead of using
alcohol-based hand gel.
Rationale: When administering hazardous drugs, hand hygiene
should be performed with soap and water rather than alcohol-
based hand gels. Alcohol-based gels are not effective at removing
or inactivating hazardous drug residues and may actually increase
dermal absorption by disrupting the skin barrier. Soap and water
physically remove contaminants from the skin. NIOSH-approved
respirators are not required for all IV administration—they are
typically indicated for specific situations like spill cleanup or when
Chemo Certification Renewal | Practice Questions,
Answers & Detailed Rationales | 2026/2027
Resource Features
➢ ONS/ONCC renewal-focused practice questions
➢ Answers for self-assessment
➢ Detailed rationales
➢ Oncology clinical scenarios
➢ Chemotherapy review
➢ Immunotherapy review
,Chemo Certification Renewal | Practice Questions,
Answers & Detailed Rationales | 2026/2027
Question 1
The standard states that gowns must:
A. be disposable
B. not have any closures or seams that HDs can pass through
C. be changed every shift if there are no specific manufacturer
recommendations
D. both a & b
Answer: D. both a & b
Rationale: USP <800> standards require that gowns used for
hazardous drug (HD) handling must be disposable and must not
have any closures or seams that could allow hazardous drugs to
penetrate through. These requirements are designed to provide a
complete barrier between the healthcare worker and potentially
harmful drug exposure. While changing gowns regularly is
important, the standard specifically mandates the disposable
nature and seam/closure integrity of gowns used for HD handling.
, Question 2
Which of the following is a general recommendation regarding
the administration of hazardous drugs?
A. A NIOSH-approved respirator is required for all intravenous
administration.
B. Reuse of gowns is appropriate if the gown remains hung up in
the same area all the time.
C. Wash hands with soap and water instead of using alcohol-
based hand gel.
D. Unspike hazardous drug bottles or bags and place in
hazardous container with tubing separate.
Answer: C. Wash hands with soap and water instead of using
alcohol-based hand gel.
Rationale: When administering hazardous drugs, hand hygiene
should be performed with soap and water rather than alcohol-
based hand gels. Alcohol-based gels are not effective at removing
or inactivating hazardous drug residues and may actually increase
dermal absorption by disrupting the skin barrier. Soap and water
physically remove contaminants from the skin. NIOSH-approved
respirators are not required for all IV administration—they are
typically indicated for specific situations like spill cleanup or when
