Department of Pharmacology: MCQs 2024
Paper 1
General pharmacology (10 marks)
1. Which of the following statement is TRUE regarding catecholamine
a. Crosses blood brain barrier
b. Crosses corneal membrane
c. Well absorbed from stomach
d. Metabolised by COMT
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
2. There is a possibility of cardiac arrhythmias if adrenaline is administered along
with
a. Ether
b. Halothane
c. Nitrous oxide
d. Isoflurane
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
3. Which of The following statement is TRUE regarding volume of distribution
a. Bound drugs undergo quick metabolism
b. Water soluble drugs have high Vd in heart failure
c. Lipid soluble drugs are quickly excreted
d. Increased in vascularity will have less
Vd Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
4. Which of the following property matches with blood brain barrier
a. Astrocytes poorly cover the endothelial cells
b. Deficient in CTZ area
c. Lipid soluble drugs poorly crosses
d. Liver disease reduces penetration of drugs
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.19
5. Redistribution is
,Department of Pharmacology: MCQs 2024
a. Movement of drug from site of administration to brain
b. Accumulation of drug intracellularly
c. Half life of drugs escalates with repeated administration
d. Drug moves from brain into muscles
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
6. Which of the following statement about Prodrug is TRUE
a. should be avoided in renal failure patients
b. preferred in liver failure patients
c. not effective in emergencies
d. Both drug and metabolite are active
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
7. Which biotransformation reactions of phase II involves microsomal enzymes
a. Sulphate conjugation
b. Glucuronide conjugation
c. Cyclization
d. Ribonucleotide conjugation
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.25.
8. Drugs with high first pass metabolism have
a. Higher sublingual dose
b. Less inter individual variation
c. High bioavailability in liver disease
d. Not dependant on hepatic blood flow
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.67.
9. In First order kinetics
a. Rate of elimination is constant
b. Constant amount is eliminated
c. Clearance decrease with concentration
d. Clearance is constant
Correct answer: d
,Department of Pharmacology: MCQs 2024
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.30
10. The following statements about half life is TRUE EXCEPT
a. Dependant on Vd and CL
b. Only elimination phase is considered
c. Decreases in zero order kinetics
d. Drugs with very short t1/2 should be given as loading dose
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.32
11. Therapeutic drug monitoring is done for
a. Antihypertensives to check the control of BP
b. Hit and Run drugs
c. Drugs with irreversible action
d. Nephrotoxic drugs in renal failure
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.34
12. Which of the following routes of drug administration is chosen in case of
medical emergency condition?
a. Topical route
b. Intravenous route
c. Oral route
d. Transdermal
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.5,9.
13. The bioavailability of the drugs given through intravenous route is
a. 25%
b. 50%
c. 75%
d. 100%
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.16.
14. In case of spinal anaesthesia the drug is injected between
a. L2 – L3
, Department of Pharmacology: MCQs 2024
b. T1-T2
c. C4- C5
d. L1-L2
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.369.
15. Majorityof drug biotransformation is known to occur in which of the following
sites?
a. Liver
b. GIT
c. Kidneys
d. Lungs
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
16. Which of the following is the major drawback with regard to bioavailabilty in
oral route of drug administration?
a. First pass metabolism
b. Poor GIT absorption
c. Drug interactions
d. Increased GIT
peristalisis Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.16
17. Which of the following statement is true with regard to teratogenicity
a. Itis a type of drug dependence
b. Congenital anomalies occurring due to various drug administration during
pregnancy
c. Drugs causing cancer in patients
d. It is type of
photosensitivity Correct answer:
b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.89
18. The Steven Johnson’s reaction as ADR is classified as
a. type I
b. type II
c. type III
Paper 1
General pharmacology (10 marks)
1. Which of the following statement is TRUE regarding catecholamine
a. Crosses blood brain barrier
b. Crosses corneal membrane
c. Well absorbed from stomach
d. Metabolised by COMT
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
2. There is a possibility of cardiac arrhythmias if adrenaline is administered along
with
a. Ether
b. Halothane
c. Nitrous oxide
d. Isoflurane
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
3. Which of The following statement is TRUE regarding volume of distribution
a. Bound drugs undergo quick metabolism
b. Water soluble drugs have high Vd in heart failure
c. Lipid soluble drugs are quickly excreted
d. Increased in vascularity will have less
Vd Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
4. Which of the following property matches with blood brain barrier
a. Astrocytes poorly cover the endothelial cells
b. Deficient in CTZ area
c. Lipid soluble drugs poorly crosses
d. Liver disease reduces penetration of drugs
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.19
5. Redistribution is
,Department of Pharmacology: MCQs 2024
a. Movement of drug from site of administration to brain
b. Accumulation of drug intracellularly
c. Half life of drugs escalates with repeated administration
d. Drug moves from brain into muscles
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
6. Which of the following statement about Prodrug is TRUE
a. should be avoided in renal failure patients
b. preferred in liver failure patients
c. not effective in emergencies
d. Both drug and metabolite are active
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
7. Which biotransformation reactions of phase II involves microsomal enzymes
a. Sulphate conjugation
b. Glucuronide conjugation
c. Cyclization
d. Ribonucleotide conjugation
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.25.
8. Drugs with high first pass metabolism have
a. Higher sublingual dose
b. Less inter individual variation
c. High bioavailability in liver disease
d. Not dependant on hepatic blood flow
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.67.
9. In First order kinetics
a. Rate of elimination is constant
b. Constant amount is eliminated
c. Clearance decrease with concentration
d. Clearance is constant
Correct answer: d
,Department of Pharmacology: MCQs 2024
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.30
10. The following statements about half life is TRUE EXCEPT
a. Dependant on Vd and CL
b. Only elimination phase is considered
c. Decreases in zero order kinetics
d. Drugs with very short t1/2 should be given as loading dose
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.32
11. Therapeutic drug monitoring is done for
a. Antihypertensives to check the control of BP
b. Hit and Run drugs
c. Drugs with irreversible action
d. Nephrotoxic drugs in renal failure
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.34
12. Which of the following routes of drug administration is chosen in case of
medical emergency condition?
a. Topical route
b. Intravenous route
c. Oral route
d. Transdermal
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.5,9.
13. The bioavailability of the drugs given through intravenous route is
a. 25%
b. 50%
c. 75%
d. 100%
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.16.
14. In case of spinal anaesthesia the drug is injected between
a. L2 – L3
, Department of Pharmacology: MCQs 2024
b. T1-T2
c. C4- C5
d. L1-L2
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.369.
15. Majorityof drug biotransformation is known to occur in which of the following
sites?
a. Liver
b. GIT
c. Kidneys
d. Lungs
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
16. Which of the following is the major drawback with regard to bioavailabilty in
oral route of drug administration?
a. First pass metabolism
b. Poor GIT absorption
c. Drug interactions
d. Increased GIT
peristalisis Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.16
17. Which of the following statement is true with regard to teratogenicity
a. Itis a type of drug dependence
b. Congenital anomalies occurring due to various drug administration during
pregnancy
c. Drugs causing cancer in patients
d. It is type of
photosensitivity Correct answer:
b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.89
18. The Steven Johnson’s reaction as ADR is classified as
a. type I
b. type II
c. type III
