Department of Pharmacology: MCQs 2023
Paper 1
General pharmacology (10 marks)
1. Which of the following statement is TRUE regarding catecholamine
a. Crosses blood brain barrier
b. Crosses corneal membrane
c. Well absorbed from stomach
d. Metabolised by COMT
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
2. There is a possibility of cardiac arrhythmias if adrenaline is administered along with
a. Ether
b. Halothane
c. Nitrous oxide
d. Isoflurane
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
3. Which of The following statement is TRUE regarding volume of distribution
a. Bound drugs undergo quick metabolism
b. Water soluble drugs have high Vd in heart failure
c. Lipid soluble drugs are quickly excreted
d. Increased in vascularity will have less Vd
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
4. Which of the following property matches with blood brain barrier
a. Astrocytes poorly cover the endothelial cells
b. Deficient in CTZ area
c. Lipid soluble drugs poorly crosses
d. Liver disease reduces penetration of drugs
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.19
5. Redistribution is
a. Movement of drug from site of administration to brain
b. Accumulation of drug intracellularly
, Department of Pharmacology: MCQs 2023
c. Half life of drugs escalates with repeated administration
d. Drug moves from brain into muscles
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
6. Which of the following statement about Prodrug is TRUE
a. should be avoided in renal failure patients
b. preferred in liver failure patients
c. not effective in emergencies
d. Both drug and metabolite are active
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
7. Which biotransformation reactions of phase II involves microsomal enzymes
a. Sulphate conjugation
b. Glucuronide conjugation
c. Cyclization
d. Ribonucleotide conjugation
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.25.
8. Drugs with high first pass metabolism have
a. Higher sublingual dose
b. Less inter individual variation
c. High bioavailability in liver disease
d. Not dependant on hepatic blood flow
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.67.
9. In First order kinetics
a. Rate of elimination is constant
b. Constant amount is eliminated
c. Clearance decrease with concentration
d. Clearance is constant
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.30
10. The following statements about half life is TRUE EXCEPT
, Department of Pharmacology: MCQs 2023
a. Dependant on Vd and CL
b. Only elimination phase is considered
c. Decreases in zero order kinetics
d. Drugs with very short t1/2 should be given as loading dose
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.32
11. Therapeutic drug monitoring is done for
a. Antihypertensives to check the control of BP
b. Hit and Run drugs
c. Drugs with irreversible action
d. Nephrotoxic drugs in renal failure
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.34
12. Which of the following routes of drug administration is chosen in case of medical
emergency condition?
a. Topical route
b. Intravenous route
c. Oral route
d. Transdermal
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.5,9.
13. The bioavailability of the drugs given through intravenous route is
a. 25%
b. 50%
c. 75%
d. 100%
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.16.
14. In case of spinal anaesthesia the drug is injected between
a. L2 – L3
b. T1-T2
c. C4- C5
d. L1-L2
Correct answer: a
, Department of Pharmacology: MCQs 2023
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.369.
15. Majorityof drug biotransformation is known to occur in which of the following sites?
a. Liver
b. GIT
c. Kidneys
d. Lungs
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
16. Which of the following is the major drawback with regard to bioavailabilty in oral route
of drug administration?
a. First pass metabolism
b. Poor GIT absorption
c. Drug interactions
d. Increased GIT peristalisis
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.16
17. Which of the following statement is true with regard to teratogenicity
a. Itis a type of drug dependence
b. Congenital anomalies occurring due to various drug administration during
pregnancy
c. Drugs causing cancer in patients
d. It is type of photosensitivity
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.89
18. The Steven Johnson’s reaction as ADR is classified as
a. type I
b. type II
c. type III
d. type IV
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.86.
19. The dechallenge in pharmacovigilance refers to
a. Stopping the administration of suspected drug
Paper 1
General pharmacology (10 marks)
1. Which of the following statement is TRUE regarding catecholamine
a. Crosses blood brain barrier
b. Crosses corneal membrane
c. Well absorbed from stomach
d. Metabolised by COMT
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
2. There is a possibility of cardiac arrhythmias if adrenaline is administered along with
a. Ether
b. Halothane
c. Nitrous oxide
d. Isoflurane
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.133.
3. Which of The following statement is TRUE regarding volume of distribution
a. Bound drugs undergo quick metabolism
b. Water soluble drugs have high Vd in heart failure
c. Lipid soluble drugs are quickly excreted
d. Increased in vascularity will have less Vd
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
4. Which of the following property matches with blood brain barrier
a. Astrocytes poorly cover the endothelial cells
b. Deficient in CTZ area
c. Lipid soluble drugs poorly crosses
d. Liver disease reduces penetration of drugs
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.19
5. Redistribution is
a. Movement of drug from site of administration to brain
b. Accumulation of drug intracellularly
, Department of Pharmacology: MCQs 2023
c. Half life of drugs escalates with repeated administration
d. Drug moves from brain into muscles
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.18
6. Which of the following statement about Prodrug is TRUE
a. should be avoided in renal failure patients
b. preferred in liver failure patients
c. not effective in emergencies
d. Both drug and metabolite are active
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
7. Which biotransformation reactions of phase II involves microsomal enzymes
a. Sulphate conjugation
b. Glucuronide conjugation
c. Cyclization
d. Ribonucleotide conjugation
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.25.
8. Drugs with high first pass metabolism have
a. Higher sublingual dose
b. Less inter individual variation
c. High bioavailability in liver disease
d. Not dependant on hepatic blood flow
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.67.
9. In First order kinetics
a. Rate of elimination is constant
b. Constant amount is eliminated
c. Clearance decrease with concentration
d. Clearance is constant
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.30
10. The following statements about half life is TRUE EXCEPT
, Department of Pharmacology: MCQs 2023
a. Dependant on Vd and CL
b. Only elimination phase is considered
c. Decreases in zero order kinetics
d. Drugs with very short t1/2 should be given as loading dose
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.32
11. Therapeutic drug monitoring is done for
a. Antihypertensives to check the control of BP
b. Hit and Run drugs
c. Drugs with irreversible action
d. Nephrotoxic drugs in renal failure
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.34
12. Which of the following routes of drug administration is chosen in case of medical
emergency condition?
a. Topical route
b. Intravenous route
c. Oral route
d. Transdermal
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.5,9.
13. The bioavailability of the drugs given through intravenous route is
a. 25%
b. 50%
c. 75%
d. 100%
Correct answer: d
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.16.
14. In case of spinal anaesthesia the drug is injected between
a. L2 – L3
b. T1-T2
c. C4- C5
d. L1-L2
Correct answer: a
, Department of Pharmacology: MCQs 2023
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.369.
15. Majorityof drug biotransformation is known to occur in which of the following sites?
a. Liver
b. GIT
c. Kidneys
d. Lungs
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.22
16. Which of the following is the major drawback with regard to bioavailabilty in oral route
of drug administration?
a. First pass metabolism
b. Poor GIT absorption
c. Drug interactions
d. Increased GIT peristalisis
Correct answer: a
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.16
17. Which of the following statement is true with regard to teratogenicity
a. Itis a type of drug dependence
b. Congenital anomalies occurring due to various drug administration during
pregnancy
c. Drugs causing cancer in patients
d. It is type of photosensitivity
Correct answer: b
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology. 7th ed.p.89
18. The Steven Johnson’s reaction as ADR is classified as
a. type I
b. type II
c. type III
d. type IV
Correct answer: c
Ref: KD Tripathi, editor. Essentials of Medical Pharmacology.7th ed.p.86.
19. The dechallenge in pharmacovigilance refers to
a. Stopping the administration of suspected drug
