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RN Medical-Surgical Competency Exam 2026 | RN-MEDSURG-COMP | 100 Advanced Practice Questions & Answers with Detailed Rationales | Complete RN Exam Prep & Study Guide

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Prepare for the RN Medical-Surgical Competency Exam — Code: RN-MEDSURG-COMP with this comprehensive 2026 advanced practice exam and study guide featuring 100 medical-surgical nursing questions with correct answers and detailed rationales. This resource provides broad review of essential RN medical-surgical competencies, including patient assessment, clinical judgment, prioritization, cardiovascular disorders, respiratory conditions, neurological disorders, gastrointestinal and genitourinary conditions, endocrine disorders, renal disease, musculoskeletal problems, hematologic disorders, oncology, fluid and electrolyte balance, perioperative nursing, pain management, infection prevention, medication safety, and patient education. Realistic clinical scenarios help learners recognize changes in patient condition, identify priority findings, determine appropriate nursing interventions, prioritize care, and evaluate patient responses. Detailed rationales explain the clinical reasoning behind each answer and reinforce safe, patient-centered medical-surgical nursing practice. Key Features 100 advanced RN medical-surgical competency questions Correct answers for every question Detailed rationales Realistic Med-Surg clinical scenarios Comprehensive patient assessment Clinical judgment and prioritization Cardiovascular nursing Respiratory nursing Neurological nursing Gastrointestinal disorders Genitourinary and renal disorders Endocrine disorders Musculoskeletal conditions Hematologic disorders Oncology nursing Fluid and electrolyte balance Acid-base concepts Perioperative nursing Pain management Infection prevention and control Medication safety Patient education Patient safety Recognition of patient deterioration Comprehensive 2026 exam preparation

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RN Medical-Surgical Competency Exam
— Code: RN-MEDSURG-COMP | 100-
Question Advanced Practice Exam 2026
| Questions & Answers with Detailed
Rationales | Complete Exam Prep &
Study Guide

1. A client with septic shock has received 30 mL/kg of crystalloid but remains
hypotensive with a MAP of 58 mm Hg. Which intervention should the nurse
anticipate next?

A. Administer IV furosemide
B. Initiate a norepinephrine infusion
C. Restrict all IV fluids
D. Administer oral antihypertensive medication

Answer: Initiate a norepinephrine infusion

Rationale: Norepinephrine is a first-line vasopressor for persistent hypotension
in septic shock after adequate fluid resuscitation. The goal is generally to
maintain a MAP of at least 65 mm Hg.

, 2. A client with acute heart failure develops severe dyspnea, crackles, pink
frothy sputum, and an oxygen saturation of 82%. Which action is the
priority?

A. Place the client flat
B. Encourage oral fluids
C. Position the client upright and administer oxygen
D. Obtain a routine weight

Answer: Position the client upright and administer oxygen

Rationale: The findings indicate acute pulmonary edema. Upright positioning
improves ventilation, while oxygen supports oxygenation while definitive
treatment is initiated.

3. A client receiving digoxin has an apical pulse of 48/min and reports nausea
and yellow-green visual disturbances. What should the nurse do?

A. Administer the medication with food
B. Give the next dose early
C. Hold digoxin and notify the provider
D. Encourage increased potassium intake without further assessment

Answer: Hold digoxin and notify the provider

Rationale: Bradycardia, gastrointestinal symptoms, and visual disturbances are
classic findings of digoxin toxicity. The medication should be withheld and the
provider notified.

4. A client with COPD is receiving oxygen at 6 L/min by nasal cannula and
becomes increasingly somnolent. Which action is most appropriate?

A. Immediately discontinue oxygen
B. Assess respiratory status and obtain an arterial blood gas
C. Place the client in Trendelenburg position
D. Encourage rapid deep breathing

Answer: Assess respiratory status and obtain an arterial blood gas

,Rationale: Increasing somnolence may indicate worsening hypercapnia or
respiratory failure. Oxygen should not be abruptly discontinued; the nurse
should assess ventilation and oxygenation and obtain appropriate diagnostic
data.

5. A client with diabetic ketoacidosis has a serum potassium of 3.0 mEq/L.
Which prescription should the nurse question?

A. IV regular insulin infusion
B. Cardiac monitoring
C. Potassium replacement
D. Isotonic IV fluids

Answer: IV regular insulin infusion

Rationale: Insulin shifts potassium into cells and can cause life-threatening
hypokalemia. When potassium is significantly low, potassium replacement is
generally required before insulin is started.

6. A client with SIADH has a serum sodium of 118 mEq/L and develops
confusion and a seizure. Which intervention is anticipated?

A. Administer hypotonic fluids
B. Encourage large amounts of free water
C. Administer prescribed hypertonic saline with close monitoring
D. Administer potassium-free IV fluids rapidly

Answer: Administer prescribed hypertonic saline with close monitoring

Rationale: Severe symptomatic hyponatremia can cause cerebral edema and
seizures. Carefully administered hypertonic saline may be prescribed, with close
monitoring to avoid overly rapid sodium correction.

7. A client with a suspected pulmonary embolism suddenly develops dyspnea,
pleuritic chest pain, tachycardia, and hypoxemia. What is the nurse's
priority?

, A. Encourage ambulation
B. Apply oxygen and rapidly assess the client
C. Administer oral fluids
D. Place the client prone

Answer: Apply oxygen and rapidly assess the client

Rationale: Acute hypoxemia is the immediate threat. Oxygen and rapid
assessment are priorities while diagnostic evaluation and anticoagulation or
other treatment are initiated.

8. A client with chronic kidney disease has potassium of 6.8 mEq/L and
peaked T waves. Which medication should the nurse anticipate
administering immediately to stabilize the myocardium?

A. Calcium gluconate
B. Oral potassium chloride
C. Ferrous sulfate
D. Sodium chloride tablets

Answer: Calcium gluconate

Rationale: IV calcium gluconate stabilizes the cardiac membrane in severe
hyperkalemia with ECG changes. It does not lower serum potassium but reduces
the immediate risk of fatal dysrhythmias.

9. A client with an upper gastrointestinal hemorrhage has BP 82/48 mm Hg,
HR 132/min, cool skin, and altered mental status. Which action has the
highest priority?

A. Offer clear liquids
B. Establish large-bore IV access
C. Administer a stool softener
D. Obtain a routine abdominal x-ray

Answer: Establish large-bore IV access

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