Ultimate Pharmacology Study Guide: Core
Principles
Module: Basic & Clinical Pharmacology
Scope: High-Yield Exam Review & NCLEX /
Advanced Board Prep
©2026 raneemhafiz03. All rights reserved. Prepared for personal study use only. Unauthorized
distribution, resale, or sharing is strictly prohibited.
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What the Body Does to the Drug
Pharmacokinetics deals with the movement of drugs through the body, broken
down into four core phases (ADME).
Absorption
Definition: Process of a drug moving from its site of administration into
the bloodstream.
Bioavailability (F): The fraction of an administered drug dose that
reaches systemic circulation unchanged.
IV Route: 100% bioavailability (F = 1.0).
Oral Route: <100% due to incomplete absorption and first-pass
metabolism.
First-Pass Effect: Oral drugs pass through the GI tract into the portal
vein and are metabolized by the liver before entering systemic
circulation.
Key Visual Anchor: Low bioavailability requires significantly higher oral
doses compared to intravenous doses.
Distribution
Definition: Reversible transfer of a drug from one location (blood) to
another within the body.
Volume of Distribution(Vd): Fluid volume required to contain the entire
drug dose in the body at the same concentration measured in the plasma.
©2026 raneemhafiz03. All rights reserved. Prepared for personal study use only. Unauthorized
distribution, resale, or sharing is strictly prohibited.
Principles
Module: Basic & Clinical Pharmacology
Scope: High-Yield Exam Review & NCLEX /
Advanced Board Prep
©2026 raneemhafiz03. All rights reserved. Prepared for personal study use only. Unauthorized
distribution, resale, or sharing is strictly prohibited.
, Your paragraph text
What the Body Does to the Drug
Pharmacokinetics deals with the movement of drugs through the body, broken
down into four core phases (ADME).
Absorption
Definition: Process of a drug moving from its site of administration into
the bloodstream.
Bioavailability (F): The fraction of an administered drug dose that
reaches systemic circulation unchanged.
IV Route: 100% bioavailability (F = 1.0).
Oral Route: <100% due to incomplete absorption and first-pass
metabolism.
First-Pass Effect: Oral drugs pass through the GI tract into the portal
vein and are metabolized by the liver before entering systemic
circulation.
Key Visual Anchor: Low bioavailability requires significantly higher oral
doses compared to intravenous doses.
Distribution
Definition: Reversible transfer of a drug from one location (blood) to
another within the body.
Volume of Distribution(Vd): Fluid volume required to contain the entire
drug dose in the body at the same concentration measured in the plasma.
©2026 raneemhafiz03. All rights reserved. Prepared for personal study use only. Unauthorized
distribution, resale, or sharing is strictly prohibited.
