NUR 111 Exam 4 q
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
1. Inflammation Is a localized reaction intended to neutralize, control or eliminate an
offending agent.
2. Inflammatory Re- Inflammation is a localized reaction intended to neutralize, control or
sponse eliminate an offending agent.
Nonspecific response to injured or dead cells
Eliminates invading pathogens
Allows for tissue repair
Occurs in response to infection or injury
Infection is one way to get inflammation but it is not the only way
Can be acute or chronic
That offening agent may be the persons own body
Not specific
A protecting mechanism that responds to injured or dead cells
Usually occurs in healthy tissue adjacent to the dead cells
3. Stages of Inflamma- 1st stage: Vascular response
tion Blood vessel response
2nd stage: Cellular Response
White blood cells
Reparative phase
They all happen very close together
4. Vascular Response Usually localized to the area of injury but can be systemic
Momentary vasoconstriction then lots of Vasodilation
Increased permeability of vasculature
Makes it easier for blood and cells to pass through the blood vessel walls
Increased concentration of blood
Due to the vasoconstriction and permeability
Clotting
Page 1
, NUR 111 Exam 4 q
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
Due to platelets rushing to the area that help clot off injury to stop the
bleeding
5. Cellular Response Leukocytes accumulate at site
Due to increased permeability of the blood vessels
Cytokines cause endothelial cells to bind to leukocytes
Cytokines are chemical messengers that tell the brain there is an injury
Leukocytes travel through the capillary into tissue
So you have white blood cells fighting infection in the tissue
Leukocytes engulf invading organisms
6. Exudate You get exudate with inflammation
If exudate starts containing bacteria and bacterial debris then it becomes
puss and is a sign of a bacterial infection and becomes part of your
excaudate
Moves into injured area after inflammatory event as part of the cellular
response
Carries
Proteins
Fluid
Lymphocytes
Monocytes
Macrophages
Granulocytes
7. Healthy exudate The whole point of it if it is health is to:
Eradicate pathogen
Remove dead tissue debris
Secrete cytokines
Initiate healing
8. Reparative Phase Glucose and oxygen travel to site needing repair
Regeneration depends on the type of cells
Page 2
, NUR 111 Exam 4 q
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
Regeneration
Labile
They multiply constantly
So they are relatively easy to regenerate
Ex. Skin cells
Permanent
Does not regenerate
Ex. Neurons
Stable
Regenerate sometimes if there is injury
Takes longer because they do not multiply constantly
Ex. Kidney or liver cells
Replacement
Replacing the tissue that was damaged
9. Acute Inflammatory Tissue injury/exposure and the release of chemical mediators
Response
Vasodilation and increased blood flow
Swelling and retraction of activated endothelial cells
Increased vascular permeability and leakage of small plasma proteins
"Walling
off"
Movement of immune response cells to the site of injury
Exudate formation
Movement of glucose and oxygen to the site needing repair
Release of
Page 3
, NUR 111 Exam 4 q
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
chemical repair
factors
from activated
endothelial
cells
10. Chemical Mediators Histamine and Kinins
11. Histamine Pro-inflammatory
Induces the vascular response
Lives in mast cells so the mast cells release the histamines which causes
vasodilation
Stimulation results in itching, pain, edema, vasodilation, and bron-
choconstriction
Anti-histamines are given to combat these symptoms
Histamine is a big chemical mediator when talking about inflammation
12. Kinins Increase vascular permeability
Attract neutrophils to the site
13. Five Signs of Inflamma- Heat
tion Redness
Swelling
Pain
Loss of function
14. Systemic Response to Fever
Inflammation Leukocytosis
Increased white blood cells
Malaise
General icky feeling
Loss of appetite
Page 4
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
1. Inflammation Is a localized reaction intended to neutralize, control or eliminate an
offending agent.
2. Inflammatory Re- Inflammation is a localized reaction intended to neutralize, control or
sponse eliminate an offending agent.
Nonspecific response to injured or dead cells
Eliminates invading pathogens
Allows for tissue repair
Occurs in response to infection or injury
Infection is one way to get inflammation but it is not the only way
Can be acute or chronic
That offening agent may be the persons own body
Not specific
A protecting mechanism that responds to injured or dead cells
Usually occurs in healthy tissue adjacent to the dead cells
3. Stages of Inflamma- 1st stage: Vascular response
tion Blood vessel response
2nd stage: Cellular Response
White blood cells
Reparative phase
They all happen very close together
4. Vascular Response Usually localized to the area of injury but can be systemic
Momentary vasoconstriction then lots of Vasodilation
Increased permeability of vasculature
Makes it easier for blood and cells to pass through the blood vessel walls
Increased concentration of blood
Due to the vasoconstriction and permeability
Clotting
Page 1
, NUR 111 Exam 4 q
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
Due to platelets rushing to the area that help clot off injury to stop the
bleeding
5. Cellular Response Leukocytes accumulate at site
Due to increased permeability of the blood vessels
Cytokines cause endothelial cells to bind to leukocytes
Cytokines are chemical messengers that tell the brain there is an injury
Leukocytes travel through the capillary into tissue
So you have white blood cells fighting infection in the tissue
Leukocytes engulf invading organisms
6. Exudate You get exudate with inflammation
If exudate starts containing bacteria and bacterial debris then it becomes
puss and is a sign of a bacterial infection and becomes part of your
excaudate
Moves into injured area after inflammatory event as part of the cellular
response
Carries
Proteins
Fluid
Lymphocytes
Monocytes
Macrophages
Granulocytes
7. Healthy exudate The whole point of it if it is health is to:
Eradicate pathogen
Remove dead tissue debris
Secrete cytokines
Initiate healing
8. Reparative Phase Glucose and oxygen travel to site needing repair
Regeneration depends on the type of cells
Page 2
, NUR 111 Exam 4 q
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
Regeneration
Labile
They multiply constantly
So they are relatively easy to regenerate
Ex. Skin cells
Permanent
Does not regenerate
Ex. Neurons
Stable
Regenerate sometimes if there is injury
Takes longer because they do not multiply constantly
Ex. Kidney or liver cells
Replacement
Replacing the tissue that was damaged
9. Acute Inflammatory Tissue injury/exposure and the release of chemical mediators
Response
Vasodilation and increased blood flow
Swelling and retraction of activated endothelial cells
Increased vascular permeability and leakage of small plasma proteins
"Walling
off"
Movement of immune response cells to the site of injury
Exudate formation
Movement of glucose and oxygen to the site needing repair
Release of
Page 3
, NUR 111 Exam 4 q
NUR 111 Exam 4
Study online at https://quizlet.com/_3yf2kx
chemical repair
factors
from activated
endothelial
cells
10. Chemical Mediators Histamine and Kinins
11. Histamine Pro-inflammatory
Induces the vascular response
Lives in mast cells so the mast cells release the histamines which causes
vasodilation
Stimulation results in itching, pain, edema, vasodilation, and bron-
choconstriction
Anti-histamines are given to combat these symptoms
Histamine is a big chemical mediator when talking about inflammation
12. Kinins Increase vascular permeability
Attract neutrophils to the site
13. Five Signs of Inflamma- Heat
tion Redness
Swelling
Pain
Loss of function
14. Systemic Response to Fever
Inflammation Leukocytosis
Increased white blood cells
Malaise
General icky feeling
Loss of appetite
Page 4
