CSOWM EXAM SCRIPT COMPLETE
QUESTIONS AND ANSWERS BUNDLED
EXAMS FULL SOLUTION
●● cholecystokinin
Answer: a hormone that is secreted by cells in the duodenum and
stimulates the release of bile into the intestine and the secretion of
enzymes by the pancreas; decreases appetite.
●● Gastric inhibitory polypeptide
Answer: Hormone, released by intestine; Inhibits gastric secretion and
motility and potentiates release of insulin from beta cells in response to
elevated blood glucose concentration. stimulated by Presence of fat and
glucose in the small intestine; promotes satiety
●● Glucagon-like peptide 1 (GLP-1)
Answer: substance released by the intestines (ileum) in response to
glucose, FA and fiber and travels to the brain- terminates eating; inhibits
gastric secretion and glucagon secretion and enhances insulin secretion
●● Ghrelin
Answer: hormone secreted by empty stomach; sends "I'm hungry"
signals to the brain; increases with time since last feeding
,●● Leptin
Answer: protein hormone secreted by fat cells; when abundant, causes
brain to increase metabolism and decrease hunger; elevated in
overweight/obese (leptin resistant)
●● hormonal response to weight loss
Answer: increased ghrelin and reduced PYY, CCK, leptin, insulin; may
persist >1 yr and lead to increased cal intake leading to weight regain
●● phentermine/topiramate (qsymia) dosage
Answer: 3.75/23mg per day x 2 weeks then increase to 7.5/46mg per
day; max dose 15/92mg only if pts have not lost >5% BW in 12 weeks
(taper gradually DT increased risk seizure)
●● phentermine/topiramate mechanism
Answer: stimulates norepinephrine in hypothal leading to appetite
suppression
●● phentermine/topiramate side effects
Answer: insomnia, dry mouth, constipation, paraesthesia, dizziness,
dysgeusia
●● phentermine/topiramate contraindications
,Answer: hyperthyroid; glaucoma, MAO inhibitor, sympathomimetic
amines
●● orlistat (xenical) dosage
Answer: prescription 120mg tid; OTC 60mg tid during or <1hr after
meal with fat
●● orlistat mechanism of action
Answer: inhibits gastric and pancreatic lipase
●● orlistat side effects
Answer: steatorrhea, fecal incontinence, decreased absorption of fat
soluble vitamins
●● Orlistat contraindications
Answer: Pregnancy, chronic malabsorption syndrome, cholestasis
●● Lorcaserin (Belviq) dosage
Answer: 10 mg bid; DC if <5% weight loss by 12 weeks
●● Lorcaserin mechanism of action
Answer: 5HT2c receptor agonist (binding site for serotonin; mood,
feeding, reproduction, anxiety); increases satiety
, ●● lorcaserin side effects
Answer: dry mouth, fatigue, constipation, hypoglycemia (in DM)
●● Lorcaserin contraindications
Answer: pts on SSRI or SNRI (increased risk serotonin syndrome),
pregnancy, breastfeeding
●● Naltrexone/Bupropion (Contrave) dosage
Answer: 8/90mg (add 1 tablet each week until reach max dose 4/d=
32/360mg); DC use if <5% BW lost in 12 wks
●● naltrexone/bupropion mechanism of action
Answer: reuptake inhibitor of dopamine and norepinephrine (bupropion)
and opioid antagonist (naltrexone) leading to decreased appetite and
cravings
●● naltrexone/bupropion side effects
Answer: N/V, constipation, headache, dizziness
●● naltrexone/bupropion contraindications
Answer: uncontrolled HTN; seizure disorders; AN/BN; drug/alcohol
addictions or withdrawal
QUESTIONS AND ANSWERS BUNDLED
EXAMS FULL SOLUTION
●● cholecystokinin
Answer: a hormone that is secreted by cells in the duodenum and
stimulates the release of bile into the intestine and the secretion of
enzymes by the pancreas; decreases appetite.
●● Gastric inhibitory polypeptide
Answer: Hormone, released by intestine; Inhibits gastric secretion and
motility and potentiates release of insulin from beta cells in response to
elevated blood glucose concentration. stimulated by Presence of fat and
glucose in the small intestine; promotes satiety
●● Glucagon-like peptide 1 (GLP-1)
Answer: substance released by the intestines (ileum) in response to
glucose, FA and fiber and travels to the brain- terminates eating; inhibits
gastric secretion and glucagon secretion and enhances insulin secretion
●● Ghrelin
Answer: hormone secreted by empty stomach; sends "I'm hungry"
signals to the brain; increases with time since last feeding
,●● Leptin
Answer: protein hormone secreted by fat cells; when abundant, causes
brain to increase metabolism and decrease hunger; elevated in
overweight/obese (leptin resistant)
●● hormonal response to weight loss
Answer: increased ghrelin and reduced PYY, CCK, leptin, insulin; may
persist >1 yr and lead to increased cal intake leading to weight regain
●● phentermine/topiramate (qsymia) dosage
Answer: 3.75/23mg per day x 2 weeks then increase to 7.5/46mg per
day; max dose 15/92mg only if pts have not lost >5% BW in 12 weeks
(taper gradually DT increased risk seizure)
●● phentermine/topiramate mechanism
Answer: stimulates norepinephrine in hypothal leading to appetite
suppression
●● phentermine/topiramate side effects
Answer: insomnia, dry mouth, constipation, paraesthesia, dizziness,
dysgeusia
●● phentermine/topiramate contraindications
,Answer: hyperthyroid; glaucoma, MAO inhibitor, sympathomimetic
amines
●● orlistat (xenical) dosage
Answer: prescription 120mg tid; OTC 60mg tid during or <1hr after
meal with fat
●● orlistat mechanism of action
Answer: inhibits gastric and pancreatic lipase
●● orlistat side effects
Answer: steatorrhea, fecal incontinence, decreased absorption of fat
soluble vitamins
●● Orlistat contraindications
Answer: Pregnancy, chronic malabsorption syndrome, cholestasis
●● Lorcaserin (Belviq) dosage
Answer: 10 mg bid; DC if <5% weight loss by 12 weeks
●● Lorcaserin mechanism of action
Answer: 5HT2c receptor agonist (binding site for serotonin; mood,
feeding, reproduction, anxiety); increases satiety
, ●● lorcaserin side effects
Answer: dry mouth, fatigue, constipation, hypoglycemia (in DM)
●● Lorcaserin contraindications
Answer: pts on SSRI or SNRI (increased risk serotonin syndrome),
pregnancy, breastfeeding
●● Naltrexone/Bupropion (Contrave) dosage
Answer: 8/90mg (add 1 tablet each week until reach max dose 4/d=
32/360mg); DC use if <5% BW lost in 12 wks
●● naltrexone/bupropion mechanism of action
Answer: reuptake inhibitor of dopamine and norepinephrine (bupropion)
and opioid antagonist (naltrexone) leading to decreased appetite and
cravings
●● naltrexone/bupropion side effects
Answer: N/V, constipation, headache, dizziness
●● naltrexone/bupropion contraindications
Answer: uncontrolled HTN; seizure disorders; AN/BN; drug/alcohol
addictions or withdrawal
