PHARMACOLOGY EXAM 1 MULTIPLE CHOICE
QUESTIONS AND ANSWERS PHARMACOKINETICS
PHARMACODYNAMICS AND DRUG SAFETY
1. The time a drug continues to produce its effect is its
A. ED50
B. maximal response
C. ceiling effect
D. onset of action
E. duration of action - CORRECT ANSWERS -E
. The drug administration route demonstrating the slowest onset of action is
A. inhalation
B. transdermal
C. intramuscular
D. sublingual
,E. intravenous - CORRECT ANSWERS -B
In order for drugs to cross the blood-brain barrier, they must be
A. ionized
B. positively charged
C. water soluble
D. lipid soluble
E. negatively charged - CORRECT ANSWERS -D
13. First-pass metabolism refers to the metabolism of drugs in the
A. kidney
B. blood vessels
C. liver
D. heart
E. adipose tissue - CORRECT ANSWERS -C
14. Drug X has a half-life of 6 hours. How much drug is left in the body 18 hours after an IV
injection of 1200 milligrams (mg)? - CORRECT ANSWERS -B
,15. Drugs that have demonstrated teratogenic effects in women are classified as Pregnancy
Category
A. B
B. C
C. D
D. X
E. NR - CORRECT ANSWERS -D= x
16. When a drug increases the rate of drug metabolism of other drugs, the process is termed
A. first-pass metabolism
B. enzyme induction
C. enzyme inhibition
D. enterohepatic cycling
E. microsomal inhibition - CORRECT ANSWERS -B
17. The rate of drug absorption would be increased by which of the following?
A. drug ionization
B. water solubility
C. positively charged drug
D. negatively charged drug
, E. lipid solubility - CORRECT ANSWERS -E
18. Which factor of individual variation is dependent upon the patient's attitude toward
treatment?
A. weight
B. age
C. genetic variation
D. placebo effect
E. gender - CORRECT ANSWERS -D
19. Which FDA pregnancy category would appear to be the safest for a developing fetus?
A. Category A
B. Category B
C. Category C
D. Category D
E. Category X - CORRECT ANSWERS -A
20. A 45-year-old female shop assistant is treated for heartburn with omeprazole. She notes
that the effect of a dose of omeprazole lasts much longer than that of a dose of the antacid
drug calcium carbonate she had previously taken. The active metabolite of omeprazole
QUESTIONS AND ANSWERS PHARMACOKINETICS
PHARMACODYNAMICS AND DRUG SAFETY
1. The time a drug continues to produce its effect is its
A. ED50
B. maximal response
C. ceiling effect
D. onset of action
E. duration of action - CORRECT ANSWERS -E
. The drug administration route demonstrating the slowest onset of action is
A. inhalation
B. transdermal
C. intramuscular
D. sublingual
,E. intravenous - CORRECT ANSWERS -B
In order for drugs to cross the blood-brain barrier, they must be
A. ionized
B. positively charged
C. water soluble
D. lipid soluble
E. negatively charged - CORRECT ANSWERS -D
13. First-pass metabolism refers to the metabolism of drugs in the
A. kidney
B. blood vessels
C. liver
D. heart
E. adipose tissue - CORRECT ANSWERS -C
14. Drug X has a half-life of 6 hours. How much drug is left in the body 18 hours after an IV
injection of 1200 milligrams (mg)? - CORRECT ANSWERS -B
,15. Drugs that have demonstrated teratogenic effects in women are classified as Pregnancy
Category
A. B
B. C
C. D
D. X
E. NR - CORRECT ANSWERS -D= x
16. When a drug increases the rate of drug metabolism of other drugs, the process is termed
A. first-pass metabolism
B. enzyme induction
C. enzyme inhibition
D. enterohepatic cycling
E. microsomal inhibition - CORRECT ANSWERS -B
17. The rate of drug absorption would be increased by which of the following?
A. drug ionization
B. water solubility
C. positively charged drug
D. negatively charged drug
, E. lipid solubility - CORRECT ANSWERS -E
18. Which factor of individual variation is dependent upon the patient's attitude toward
treatment?
A. weight
B. age
C. genetic variation
D. placebo effect
E. gender - CORRECT ANSWERS -D
19. Which FDA pregnancy category would appear to be the safest for a developing fetus?
A. Category A
B. Category B
C. Category C
D. Category D
E. Category X - CORRECT ANSWERS -A
20. A 45-year-old female shop assistant is treated for heartburn with omeprazole. She notes
that the effect of a dose of omeprazole lasts much longer than that of a dose of the antacid
drug calcium carbonate she had previously taken. The active metabolite of omeprazole
