CRCM BSA AML FINANCIAL CRIME PREVENTION TRANSACTION MONITORING SANCTIONS SCREENING EVALUATION EXAMINATION TEST

CRCM BSA AML FINANCIAL CRIME
PREVENTION TRANSACTION
MONITORING SANCTIONS SCREENING
EVALUATION EXAMINATION TEST

●● Where does hematopoiesis occur?
Answer: In the red bone marrow


●● What is a hemocytoblast?
Answer: A pluripotent stem cell capable of differentiating into all blood
cell types


●● What do myeloid stem cells differentiate into?
Answer: Myeloblasts, erythroblasts, megakaryoblasts, and monoblasts


●● What is the diagnostic criterion for AML?
Answer: ≥ 20% myeloblasts in bone marrow


●● What characterizes the pathophysiology of AML?
Answer: A block in differentiation at the myeloblast stage, leading to
excessive proliferation of immature myeloblasts

, ●● What is the most clinically relevant subtype of AML?
Answer: M3 subtype: Acute Promyelocytic Leukemia (APL)


●● What are Auer rods?
Answer: Rod-shaped cytoplasmic inclusions found in AML myeloblasts


●● What is a hallmark enzyme for lymphoblasts in ALL?
Answer: Terminal deoxynucleotidyl transferase (TdT)


●● What percentage of ALL cases are B-cell ALL?
Answer: Approximately 80%


●● What is the significance of the Philadelphia chromosome in ALL?
Answer: It produces the BCR-ABL1 fusion gene, which activates
tyrosine kinase signaling and is associated with poor prognosis


●● What is pancytopenia?
Answer: A deficiency of all blood cells due to leukemic blasts crowding
out normal hematopoiesis


●● What are common symptoms of anemia due to pancytopenia?
Answer: Fatigue, pallor, dyspnea