CPHON COMPREHENSIVE ASSESSMENT
2026 SOLVED QUESTIONS SOLUTIONS
GRADED A+
◉ cytarabine
Answer: conjunctivitis, needs to be on steroid drops
◉ Nitrosources
Answer: subset of alkalyting agents, stops or slows enzyme that
repair DNA
◉ Nitrosources include:
Answer: carmustine, lomostine
◉ Nitrosources S/S
Answer: mylosuppression, pulmonary fibrosis
◉ antitumor agents
Answer: enters and breaks DNA or stops/slows synthesis- non cell
cycle specific
,◉ antitumor agents include:
Answer: belomycin, dactinomycin, dauno, mitomycin, doxo,
idarubicin
◉ antitumor agents S/S
Answer: pulmonary and cardic issues
have cumulative life doses
◉ Bleomycin
Answer: pulmonary fibrosis
◉ steroids
Answer: enters cells passively and modifies transcription process,
kills off lymphocytes
◉ monoclonal antibodies
Answer: -restore, enhance, or mimic immune system. attacks and
seeks out proteins on cancer cells linked to cell growth
-can reactivate CMV, Hep B, HSV, VZV
-increased toxicity and immunosuppression
◉ Rituximab
, Answer: kills CD20+ B cells that produce antibody (hodgkins
lymphoma use?)
◉ Bispecific T cell engagers
Answer: tumors recognized and eaten
-Blina
◉ antibody drug conjugates
Answer: ADC is engulfed by cancer cells then destroy cells
Includes:
Gemtuzumab ozogamicin, Brentuximab vedotin
◉ Check point inhibitors
Answer: release brakes so immune system can work: PD1 or PDL-1
includes:
keytruda, opdivo, yervoy
◉ cytokines
Answer: signal immune response- interferons and interleukins
◉ IL-2
Answer: common used in NB
2026 SOLVED QUESTIONS SOLUTIONS
GRADED A+
◉ cytarabine
Answer: conjunctivitis, needs to be on steroid drops
◉ Nitrosources
Answer: subset of alkalyting agents, stops or slows enzyme that
repair DNA
◉ Nitrosources include:
Answer: carmustine, lomostine
◉ Nitrosources S/S
Answer: mylosuppression, pulmonary fibrosis
◉ antitumor agents
Answer: enters and breaks DNA or stops/slows synthesis- non cell
cycle specific
,◉ antitumor agents include:
Answer: belomycin, dactinomycin, dauno, mitomycin, doxo,
idarubicin
◉ antitumor agents S/S
Answer: pulmonary and cardic issues
have cumulative life doses
◉ Bleomycin
Answer: pulmonary fibrosis
◉ steroids
Answer: enters cells passively and modifies transcription process,
kills off lymphocytes
◉ monoclonal antibodies
Answer: -restore, enhance, or mimic immune system. attacks and
seeks out proteins on cancer cells linked to cell growth
-can reactivate CMV, Hep B, HSV, VZV
-increased toxicity and immunosuppression
◉ Rituximab
, Answer: kills CD20+ B cells that produce antibody (hodgkins
lymphoma use?)
◉ Bispecific T cell engagers
Answer: tumors recognized and eaten
-Blina
◉ antibody drug conjugates
Answer: ADC is engulfed by cancer cells then destroy cells
Includes:
Gemtuzumab ozogamicin, Brentuximab vedotin
◉ Check point inhibitors
Answer: release brakes so immune system can work: PD1 or PDL-1
includes:
keytruda, opdivo, yervoy
◉ cytokines
Answer: signal immune response- interferons and interleukins
◉ IL-2
Answer: common used in NB
