Path 222 - Test 1
Path 222 - Test 1
Study online at https://quizlet.com/_h94el1
1. What is atherosclerosis char- Characterized by fatty depsits of lipids with the intima of the
acterized as? artery.
2. What is the first step in the Damage to the endothelial lining of an artery.
formation of atheroscloris?
3. What are some ways the en- 1. Hypertension
dothelial lining can get in- 2. Tobacco use
jured? (There are a bunch, 3. Hyperlipidemia
name 3) 4. Diabetes,
5. Infections
6. Hyperhomocysteinemia
4. What is the first indication of Fatty Streak
atheroma development?
5. What is a fatty streak in ather- Lipids accumulate and migrate into smooth muscle cells.
osclerosis?
6. What stage of atheroma de- Fibrous Plaque, it is characterized by collagen forming over the
velopment occurs after the fatty streak.
fatty streak and how is it char-
acterized?
7. What stage of atheroma de- Complicated Lesion, as the fibrous plaque grows it can cause
velopment occurs after the fi- the arteries inner wall to rupture. This leads to a development
brous plaque and how is it of a thrombus over the fibrous plaque further occulding the
characterized? artery.
8.
1 of 14
, Path 222 - Test 1
Path 222 - Test 1
Study online at https://quizlet.com/_h94el1
What are the two fac- 1. the inherited predisposition to develop new blood vessels
tors which contribute to the (angiogenesis) and
growth of collateral circula- 2. the presence of chronic ischemia.
tion?
9. What is the classification of HMG-COA Reductase Inhibitors
atvorvastatin?
10. What is the mechanism of ac- Inhibits the enzyme HMG-CoA reductase which is produced
tion of atvorvastatin? by the liver. This reduces LDL production and increases the
number of LDL receptors to recycle LDL-C from the circulation
back into the liver.
11. What is the adverse effect myopathy (which may progress to rhabdomyolysis)
of atvorvastatin that is also
known as muscle loss?
12. How does grapefruit interact It increases the levels of statins in your body.
with statins?
13. How do you decribe chronic It occurs at a predicably with the same pattern of onset, dura-
stable angina? tion and intensity of symptoms.
14. How is pain generated from When the myocardial cells are deprived oxygen and glucose for
angina? aerobic metabolism, anaerobic metabolism begins and lactic
acid accumulates.
Myocardial nerve fibers are irritated by the increased lactic acid
and transmit a pain message to the cardiac nerves.
15. The lactic acid generated Left shoulder and arm
from angina can also irritate
the upper thoracic posterior
nerve roots this causes re-
2 of 14
Path 222 - Test 1
Study online at https://quizlet.com/_h94el1
1. What is atherosclerosis char- Characterized by fatty depsits of lipids with the intima of the
acterized as? artery.
2. What is the first step in the Damage to the endothelial lining of an artery.
formation of atheroscloris?
3. What are some ways the en- 1. Hypertension
dothelial lining can get in- 2. Tobacco use
jured? (There are a bunch, 3. Hyperlipidemia
name 3) 4. Diabetes,
5. Infections
6. Hyperhomocysteinemia
4. What is the first indication of Fatty Streak
atheroma development?
5. What is a fatty streak in ather- Lipids accumulate and migrate into smooth muscle cells.
osclerosis?
6. What stage of atheroma de- Fibrous Plaque, it is characterized by collagen forming over the
velopment occurs after the fatty streak.
fatty streak and how is it char-
acterized?
7. What stage of atheroma de- Complicated Lesion, as the fibrous plaque grows it can cause
velopment occurs after the fi- the arteries inner wall to rupture. This leads to a development
brous plaque and how is it of a thrombus over the fibrous plaque further occulding the
characterized? artery.
8.
1 of 14
, Path 222 - Test 1
Path 222 - Test 1
Study online at https://quizlet.com/_h94el1
What are the two fac- 1. the inherited predisposition to develop new blood vessels
tors which contribute to the (angiogenesis) and
growth of collateral circula- 2. the presence of chronic ischemia.
tion?
9. What is the classification of HMG-COA Reductase Inhibitors
atvorvastatin?
10. What is the mechanism of ac- Inhibits the enzyme HMG-CoA reductase which is produced
tion of atvorvastatin? by the liver. This reduces LDL production and increases the
number of LDL receptors to recycle LDL-C from the circulation
back into the liver.
11. What is the adverse effect myopathy (which may progress to rhabdomyolysis)
of atvorvastatin that is also
known as muscle loss?
12. How does grapefruit interact It increases the levels of statins in your body.
with statins?
13. How do you decribe chronic It occurs at a predicably with the same pattern of onset, dura-
stable angina? tion and intensity of symptoms.
14. How is pain generated from When the myocardial cells are deprived oxygen and glucose for
angina? aerobic metabolism, anaerobic metabolism begins and lactic
acid accumulates.
Myocardial nerve fibers are irritated by the increased lactic acid
and transmit a pain message to the cardiac nerves.
15. The lactic acid generated Left shoulder and arm
from angina can also irritate
the upper thoracic posterior
nerve roots this causes re-
2 of 14
